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Contents and Authors

Allosteric Modulation of G Protein–Coupled Receptors, Lauren T. May, Katie Leach, Patrick M. Sexton, Arthur Christopoulos

Pharmacogenomic and Structural Analysis of Constitutive G Protein–Coupled Receptor Activity, Martine J. Smit, Henry F. Vischer, Remko A. Bakker, Aldo Jongejan, Henk Timmerman, Leonardo Pardo, Rob Leurs

Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway, Thomas W. Kensler, Nobunao Wakabayashi, Shyam Biswal

Cell Signaling and Neuronal Death, Makoto R. Hara, Solomon H. Snyder

Mitochondrial Oxidative Stress: Implications for Cell Death, Sten Orrenius, Vladimir Gogvadze, Boris Zhivotovsky

AMP-Activated Protein Kinase as a Drug Target, Hardie, D. Grahame

Intracellular Targets of Matrix Metalloproteinase-2 in Cardiac Disease: Rationale and Therapeutic Approaches, Richard Schulz

Arsenic: Signal Transduction, Transcription Factor, and Biotransformation Involved in Cellular Response and Toxicity, Yoshito Kumagai, Daigo Sumi

Aldo-Keto Reductases and Bioactivation/Detoxication, Yi Jin, Trevor M. Penning

Carbonyl Reductases: The Complex Relationships of Mammalian Carbonyl- and Quinone-Reducing Enzymes and Their Role in Physiology, Udo Oppermann

Drug Targeting to the Brain, A. G. de Boer, P. J. Gaillard

Mechanism-Based Pharmacokinetic-Pharmacodynamic Modeling: Biophase Distribution, Receptor Theory, and Dynamical Systems Analysis, Meindert Danhof, Joost de Jongh, Elizabeth C.M. De Lange, Oscar Della Pasqua, Bart A. Ploeger, Rob A. Voskuyl

The Functional Impact of SLC6 Transporter Genetic Variation, Maureen K. Hahn, Randy D. Blakely

mTOR Pathway as a Target in Tissue Hypertrophy, Chung Han Lee, Ken Inoki, Kun Liang Guan

Diseases Caused by Defects in the Visual Cycle: Retinoids as Potential Therapeutic Agents, Gabriel H. Travis, Marcin Golczak, Alexander R. Moise, Krzysztof Palczewski

Idiosyncratic Drug Reactions: Current Understanding, Jack Uetrecht

Non-Nicotinic Therapies for Smoking Cessation, Eric C.K. Siu, Rachel F. Tyndale

The Obesity Epidemic: Current and Future Pharmacological Treatments, Karl G. Hofbauer, Janet R. Nicholson, Olivier Boss

Circadian Rhythms: Mechanisms and Therapeutic Implications, Francis Levi, Ueli Schibler

Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations, Michael P. Murphy, Robin A.J. Smith

Acute Effects of Estrogen on Neuronal Physiology, Catherine S. Woolley

New Insights into the Mechanism of Action of Amphetamines, Annette E. Fleckenstein, Trent J. Volz, Evan L. Riddle, James W. Gibb, Glen R. Hanson

Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System, John A. Dani, Daniel Bertrand

Contrasting Actions of Endothelin ET_A and ET_B Receptors in Cardiovascular Disease, Markus P. Schneider, Erika I. Boesen, David M. Pollock

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ISSN: 0362-1642
ISBN: 978-0-8243-0447-8

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