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Annual Review of Cell and Developmental Biology

Volume 39, 2023

Following the Birth, Life, and Death of mRNAs in Single Cells

Abstract

Recent advances in single-molecule imaging of mRNAs in fixed and living cells have enabled the lives of mRNAs to be studied with unprecedented spatial and temporal detail. These approaches have moved beyond simply being able to observe specific events and have begun to allow an understanding of how regulation is coupled between steps in the mRNA life cycle. Additionally, these methodologies are now being applied in multicellular systems and animals to provide more nuanced insights into the physiological regulation of RNA metabolism.

Keyword(s): fluorescence microscopy, mRNA decay, RNA localization, splicing, transcription, translation
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/content/journals/10.1146/annurev-cellbio-022723-024045
2023-10-16
2024-04-29
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/content/journals/10.1146/annurev-cellbio-022723-024045
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Following the Birth, Life, and Death of mRNAs in Single Cells
Annual Review of Cell and Developmental Biology 39, 253 (2023); https://doi.org/10.1146/annurev-cellbio-022723-024045
/content/journals/10.1146/annurev-cellbio-022723-024045
/content/journals/10.1146/annurev-cellbio-022723-024045
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