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Annual Review of Chemical and Biomolecular Engineering

Volume 6, 2015

Particle Formation and Product Formulation Using Supercritical Fluids

Abstract

Traditional methods for solids processing involve either high temperatures, necessary for melting or viscosity reduction, or hazardous organic solvents. Owing to the negative impact of the solvents on the environment, especially on living organisms, intensive research has focused on new, sustainable methods for the processing of these substances. Applying supercritical fluids for particle formation may produce powders and composites with special characteristics. Several processes for formation and design of solid particles using dense gases have been studied intensively. The unique thermodynamic and fluid-dynamic properties of supercritical fluids can be used also for impregnation of solid particles or for the formation of solid powderous emulsions and particle coating, e.g., for formation of solids with unique properties for use in different applications. We give an overview of the application of sub- and supercritical fluids as green processing media for particle formation processes and present recent advances and trends in development.

Keyword(s): antisolvent processes, dense gases, micronization, PGSS™, rapid expansion, spray extraction
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/content/journals/10.1146/annurev-chembioeng-061114-123317
2015-07-24
2024-05-09
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Particle Formation and Product Formulation Using Supercritical Fluids
Annual Review of Chemical and Biomolecular Engineering 6, 379 (2015); https://doi.org/10.1146/annurev-chembioeng-061114-123317
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