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Annual Review of Chemical and Biomolecular Engineering

Volume 14, 2023

RNAs as Sensors of Oxidative Stress in Bacteria

Abstract

Oxidative stress is an important and pervasive physical stress encountered by all kingdoms of life, including bacteria. In this review, we briefly describe the nature of oxidative stress, highlight well-characterized protein-based sensors (transcription factors) of reactive oxygen species that serve as standards for molecular sensors in oxidative stress, and describe molecular studies that have explored the potential of direct RNA sensitivity to oxidative stress. Finally, we describe the gaps in knowledge of RNA sensors—particularly regarding the chemical modification of RNA nucleobases. RNA sensors are poised to emerge as an essential layer of understanding and regulating dynamic biological pathways in oxidative stress responses in bacteria and, thus, also represent an important frontier of synthetic biology.

Keyword(s): bacterial stress response, oxidative stress, reactive oxygen species, RNA oxidation, RNA sensors, ROS, synthetic biology
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2023-06-08
2024-04-27
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/content/journals/10.1146/annurev-chembioeng-101121-070250
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RNAs as Sensors of Oxidative Stress in Bacteria
Annual Review of Chemical and Biomolecular Engineering 14, 265 (2023); https://doi.org/10.1146/annurev-chembioeng-101121-070250
/content/journals/10.1146/annurev-chembioeng-101121-070250
/content/journals/10.1146/annurev-chembioeng-101121-070250
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