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Annual Review of Microbiology

Volume 76, 2022

Egress Across the Parasite Life Cycle

Abstract

Human malaria, caused by infection with parasites, remains one of the most important global public health problems, with the World Health Organization reporting more than 240 million cases and 600,000 deaths annually as of 2020 (). Our understanding of the biology of these parasites is critical for development of effective therapeutics and prophylactics, including both antimalarials and vaccines. is a protozoan organism that is intracellular for most of its life cycle. However, to complete its complex life cycle and to allow for both amplification and transmission, the parasite must egress out of the host cell in a highly regulated manner. This review discusses the major pathways and proteins involved in the egress events during the life cycle—merozoite and gametocyte egress out of red blood cells, sporozoite egress out of the oocyst, and merozoite egress out of the hepatocyte. The similarities, as well as the differences, between the various egress pathways of the parasite highlight both novel cell biology and potential therapeutic targets to arrest its life cycle.

Keyword(s): malaria, protease, protein kinase G, second messenger, SUB1
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2022-09-08
2024-05-10
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Plasmodium Egress Across the Parasite Life Cycle
Annual Review of Microbiology 76, 67 (2022); https://doi.org/10.1146/annurev-micro-041320-020659
/content/journals/10.1146/annurev-micro-041320-020659
/content/journals/10.1146/annurev-micro-041320-020659
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