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Annual Review of Microbiology

Volume 76, 2022

The Making of a Heterocyst in Cyanobacteria

Abstract

Heterocyst differentiation that occurs in some filamentous cyanobacteria, such as sp. PCC 7120, provides a unique model for prokaryotic developmental biology. Heterocyst cells are formed in response to combined-nitrogen deprivation and possess a microoxic environment suitable for nitrogen fixation following extensive morphological and physiological reorganization. A filament of is a true multicellular organism, as nitrogen and carbon sources are exchanged among different cells and cell types through septal junctions to ensure filament growth. Because heterocysts are terminally differentiated cells and unable to divide, their activity is an altruistic behavior dedicated to providing fixed nitrogen for neighboring vegetative cells. Heterocyst development is also a process of one-dimensional pattern formation, as heterocysts are semiregularly intercalated among vegetative cells. Morphogens form gradients along the filament and interact with each other in a fashion that fits well into the Turing model, a mathematical framework to explain biological pattern formation.

Keyword(s): cell-cell communication, morphogen, multicellularity, nitrogen fixation, pattern formation, Turing pattern
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2022-09-08
2024-05-20
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/content/journals/10.1146/annurev-micro-041320-093442
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The Making of a Heterocyst in Cyanobacteria
Annual Review of Microbiology 76, 597 (2022); https://doi.org/10.1146/annurev-micro-041320-093442
/content/journals/10.1146/annurev-micro-041320-093442
/content/journals/10.1146/annurev-micro-041320-093442
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