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Annual Review of Physiology

Volume 86, 2024

Mitochondrial Dysfunction in Kidney Tubulopathies

Abstract

Mitochondria play a key role in kidney physiology and pathology. They produce ATP to fuel energy-demanding water and solute reabsorption processes along the nephron. Moreover, mitochondria contribute to cellular health by the regulation of autophagy, (oxidative) stress responses, and apoptosis. Mitochondrial abundance is particularly high in cortical segments, including proximal and distal convoluted tubules. Dysfunction of the mitochondria has been described for tubulopathies such as Fanconi, Gitelman, and Bartter-like syndromes and renal tubular acidosis. In addition, mitochondrial cytopathies often affect renal (tubular) tissues, such as in Kearns-Sayre and Leigh syndromes. Nevertheless, the mechanisms by which mitochondrial dysfunction results in renal tubular diseases are only scarcely being explored. This review provides an overview of mitochondrial dysfunction in the development and progression of kidney tubulopathies. Furthermore, it emphasizes the need for further mechanistic investigations to identify links between mitochondrial function and renal electrolyte reabsorption.

Keyword(s): Bartter syndrome, Fanconi syndrome, Gitelman syndrome, Kearns-Sayre syndrome, Leigh syndrome, mitochondria, mitochondrial cytopathy, renal tubulopathy
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2024-02-12
2024-04-27
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/content/journals/10.1146/annurev-physiol-042222-025000
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Mitochondrial Dysfunction in Kidney Tubulopathies
Annual Review of Physiology 86, 379 (2024); https://doi.org/10.1146/annurev-physiol-042222-025000
/content/journals/10.1146/annurev-physiol-042222-025000
/content/journals/10.1146/annurev-physiol-042222-025000
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