The Structure of the Nuclear Pore Complex: Supplemental Video 1

A supplemental video from the 2011 review by André Hoelz, Erik W. Debler, and Günter Blobel, "The Structure of the Nuclear Pore Complex," from the Annual Review of Biochemistry.

Overall, the nuclear pore complex (NPC) consists of a cylindrical, symmetric core, which is asymmetrically decorated with filaments and a nuclear basket structure on the cytoplasmic and nucleoplasmic sides, respectively. Molecules smaller than ∼40 kDa (small spheres) freely diffuse through the NPC, whereas larger noncargo molecules (large spheres) are prevented from crossing the nuclear envelope. Artwork by Joseph Alexander, Erik W. Debler, and André Hoelz.