The Structure of the Nuclear Pore Complex: Supplemental Video 4

A supplemental video from the 2011 review by André Hoelz, Erik W. Debler, and Günter Blobel, "The Structure of the Nuclear Pore Complex," from the Annual Review of Biochemistry.

Inner nuclear membrane (INM) proteins are cotranslationally integrated into the endoplasmic reticulum membrane, which is continuous with the outer nuclear membrane, and then imported to the INM. Similar to the karyopherin-mediated transport in Movie 2, the transport of INM proteins is also dependent on the Ran cycle and karyopherins that likely travel through the central channel, whereas the cargo protein is anchored in the membrane. INM proteins, Kap-α, Kap-β, and RanGTP, are illustrated in light purple, light green, brown, and red, respectively. Substantial structural changes within the NPC would be necessary to facilitate this transport event. Artwork by Joseph Alexander, Erik W. Debler, and André Hoelz.