Deep Recombination: RNA and ssDNA Virus Genes in DNA Virus and Host Genomes: Video 1

A video from the 2015 review by Kenneth M. Stedman, "Deep Recombination: RNA and ssDNA Virus Genes in DNA Virus and Host Genomes," from the Annual Review of Virology.

Shown: Schematic of different virus classes [after Baltimore 1971 (10)] and the integration of some viruses into cellular genomes. Black arrows represent DNA. Red arrows represent RNA. Blue hexagons represent virus capsids. Blue arrows represent virus replication mechanisms to produce mRNA for protein translation. Gray arrows represent integration into the host genome, with the thickness of the arrow representing the gross frequency of recombination. The recombination arrow from Class VI viruses, the retroviruses, proceeds through a dsDNA intermediate. Recombination between ssDNA viruses (Class II) and dsDNA genomes may proceed through dsDNA (lower arrow) or directly as ssDNA (upper arrow) (55). Recombination between Class V and Class III viruses is probably mediated by cellular retrotransposons (see Figure 2). Download a PowerPoint version of the animation.