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Annual Review of Analytical Chemistry

Volume 10, 2017

Magnetic Resonance Spectroscopy as a Tool for Assessing Macromolecular Structure and Function in Living Cells

Abstract

Investigating the structure, modification, interaction, and function of biomolecules in their native cellular environment leads to physiologically relevant knowledge about their mechanisms, which will benefit drug discovery and design. In recent years, nuclear and electron magnetic resonance (NMR) spectroscopy has emerged as a useful tool for elucidating the structure and function of biomacromolecules, including proteins, nucleic acids, and carbohydrates in living cells at atomic resolution. In this review, we summarize the progress and future of in-cell NMR as it is applied to proteins, nucleic acids, and carbohydrates.

Keyword(s): in-cell NMR, posttranslational modification, protein interaction, protein structure, RNA
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2017-06-12
2024-04-25
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Magnetic Resonance Spectroscopy as a Tool for Assessing Macromolecular Structure and Function in Living Cells
Annual Review of Analytical Chemistry 10, 157 (2017); https://doi.org/10.1146/annurev-anchem-061516-045237
/content/journals/10.1146/annurev-anchem-061516-045237
/content/journals/10.1146/annurev-anchem-061516-045237
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