Cellular Homeostasis and Aging

Literature Cited

1. Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R. 1.  1993. A C. elegans mutant that lives twice as long as wild type. Nature 366:461–64 [Google Scholar]
2. Balch WE, Morimoto RI, Dillin A, Kelly JW. 2.  2008. Adapting proteostasis for disease intervention. Science 319:916–19 [Google Scholar]
3. Kim YE, Hipp MS, Bracher A, Hayer-Hartl M, Hartl FU. 3.  2013. Molecular chaperone functions in protein folding and proteostasis. Annu. Rev. Biochem. 82:323–55 [Google Scholar]
4. Brehme M, Voisine C, Rolland T, Wachi S, Soper JH. 4.  et al. 2014. A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease. Cell Rep. 9:1135–50 [Google Scholar]
5. Ben-Zvi A, Miller EA, Morimoto RI. 5.  2009. Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging. PNAS 106:14914–19 [Google Scholar]
6. Douglas PM, Dillin A. 6.  2010. Protein homeostasis and aging in neurodegeneration. J. Cell Biol. 190:719–29 [Google Scholar]
7. Hipp MS, Park S-H, Hartl FU. 7.  2014. Proteostasis impairment in protein-misfolding and -aggregation diseases. Trends Cell Biol. 24:506–14 [Google Scholar]
8. Kirstein J, Morito D, Kakihana T, Sugihara M, Minnen A. 8.  et al. 2015. Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments. EMBO J. 34:2334–49 [Google Scholar]
9. Olzscha H, Schermann SM, Woerner AC, Pinkert S, Hecht MH. 9.  et al. 2011. Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions. Cell 144:67–78 [Google Scholar]
10. Woerner AC, Frottin F, Hornburg D, Feng LR, Meissner F. 10.  et al. 2016. Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA. Science 351:173–76 [Google Scholar]
11. Riera CE, Merkwirth C, De Magalhaes Filho CD, Dillin A. 11.  2016. Signaling networks determining life span. Annu. Rev. Biochem. 85:35–64 [Google Scholar]
12. Anckar J, Sistonen L. 12.  2011. Regulation of HSF1 function in the heat stress response: implications in aging and disease. Annu. Rev. Biochem. 80:1089–115 [Google Scholar]
13. Hsu AL, Murphy CT, Kenyon C. 13.  2003. Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science 300:1142–45 [Google Scholar]
14. Baird NA, Douglas PM, Simic MS, Grant AR, Moresco JJ. 14.  et al. 2014. HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span. Science 346:360–63 [Google Scholar]
15. Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G. 15.  et al. 2015. Widespread proteome remodeling and aggregation in aging C. elegans. Cell 161:919–32 [Google Scholar]
16. Labbadia J, Morimoto RI. 16.  2015. Repression of the heat shock response is a programmed event at the onset of reproduction. Mol. Cell 59:639–50 [Google Scholar]
17. Zoncu R, Efeyan A, Sabatini DM. 17.  2011. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell Biol. 12:21–35 [Google Scholar]
18. Walter P, Ron D. 18.  2011. The unfolded protein response: from stress pathway to homeostatic regulation. Science 334:1081–86 [Google Scholar]
19. Schulz AM, Haynes CM. 19.  2015. UPR(mt)-mediated cytoprotection and organismal aging. Biochim. Biophys. Acta 1847:1448–56 [Google Scholar]
20. Dillin A, Hsu AL, Arantes-Oliveira N, Lehrer-Graiwer J, Hsin H. 20.  et al. 2002. Rates of behavior and aging specified by mitochondrial function during development. Science 298:2398–401 [Google Scholar]
21. Soultoukis GA, Partridge L. 21.  2016. Dietary protein, metabolism, and aging. Annu. Rev. Biochem. 85:5–34 [Google Scholar]
22. Fontana L, Partridge L. 22.  2015. Promoting health and longevity through diet: from model organisms to humans. Cell 161:106–18 [Google Scholar]