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Annual Review of Biophysics

Volume 43, 2014

Itch Mechanisms and Circuits

Abstract

The itch-scratch reflex serves as a protective mechanism in everyday life. However, chronic persistent itching can be devastating. Despite the clinical importance of the itch sensation, its mechanism remains elusive. In the past decade, substantial progress has been made to uncover the mystery of itching. Here, we review the molecules, cells, and circuits known to mediate the itch sensation, which, coupled with advances in understanding the pathophysiology of chronic itching conditions, will hopefully contribute to the development of new anti-itch therapies.

Keyword(s): itch, neural circuits, neurons, pain, pruritus, sensitization
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/content/journals/10.1146/annurev-biophys-051013-022826
2014-05-06
2024-04-26
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Itch Mechanisms and Circuits
Annual Review of Biophysics 43, 331 (2014); https://doi.org/10.1146/annurev-biophys-051013-022826
/content/journals/10.1146/annurev-biophys-051013-022826
/content/journals/10.1146/annurev-biophys-051013-022826
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