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Annual Review of Cell and Developmental Biology

Volume 32, 2016

Regulation of Hematopoiesis and Osteogenesis by Blood Vessel–Derived Signals

Abstract

In addition to their conventional role as a versatile transport system, blood vessels provide signals controlling organ development, regeneration, and stem cell behavior. In the skeletal system, certain capillaries support perivascular osteoprogenitor cells and thereby control bone formation. Blood vessels are also a critical component of niche microenvironments for hematopoietic stem cells. Here we discuss key pathways and factors controlling endothelial cell behavior in bone, the role of vessels in osteogenesis, and the nature of vascular stem cell niches in bone marrow.

Keyword(s): angiocrine factors, bone angiogenesis, hematopoietic stem cells, vascular niche
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/content/journals/10.1146/annurev-cellbio-111315-124936
2016-10-06
2024-04-19
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Regulation of Hematopoiesis and Osteogenesis by Blood Vessel–Derived Signals
Annual Review of Cell and Developmental Biology 32, 649 (2016); https://doi.org/10.1146/annurev-cellbio-111315-124936
/content/journals/10.1146/annurev-cellbio-111315-124936
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