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Annual Review of Genetics

Volume 50, 2016

Aneuploidy in Cancer and Aging

Abstract

Chromosomal instability (CIN), the persistent inability of a cell to faithfully segregate its genome, is a feature of many cancer cells. It stands to reason that CIN enables the acquisition of multiple cancer hallmarks; however, there is a growing body of evidence suggesting that CIN impairs cellular fitness and prevents neoplastic transformation. Here, we suggest a new perspective to reconcile this apparent paradox and share an unexpected link between aneuploidy and aging that was discovered through attempts to investigate the CIN-cancer relationship. Additionally, we provide a comprehensive overview of the function and regulation of the anaphase-promoting complex, an E3 ubiquitin ligase that mediates high-fidelity chromosome segregation, and describe the mechanisms that lead to whole-chromosome gain or loss. With this review, we aim to expand our understanding of the role of CIN in cancer and aging with the long-term objective of harnessing this information for the advancement of patient care.

Keyword(s): anaphase-promoting complex/cyclosome, chromosomal instability
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2016-11-23
2024-04-19
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Aneuploidy in Cancer and Aging
Annual Review of Genetics 50, 45 (2016); https://doi.org/10.1146/annurev-genet-120215-035303
/content/journals/10.1146/annurev-genet-120215-035303
/content/journals/10.1146/annurev-genet-120215-035303
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