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Annual Review of Genomics and Human Genetics

Volume 17, 2016

Host Factors in Ebola Infection

Abstract

Ebola virus (EBOV) emerged in West Africa in 2014 to devastating effect, and demonstrated that infection can cause a broad range of severe disease manifestations. As the virus itself was genetically similar to other Zaire ebolaviruses, the spectrum of pathology likely resulted from variable responses to infection in a large and genetically diverse population. This review comprehensively summarizes current knowledge of the host response to EBOV infection, including pathways hijacked by the virus to facilitate replication, host processes that contribute directly to pathogenesis, and host-pathogen interactions involved in subverting or antagonizing host antiviral immunity.

Keyword(s): ebolavirus, filovirus, host response, pathogenesis
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/content/journals/10.1146/annurev-genom-083115-022446
2016-08-31
2024-04-19
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Host Factors in Ebola Infection
Annual Review of Genomics and Human Genetics 17, 333 (2016); https://doi.org/10.1146/annurev-genom-083115-022446
/content/journals/10.1146/annurev-genom-083115-022446
/content/journals/10.1146/annurev-genom-083115-022446
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