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Annual Review of Immunology

Volume 28, 2009

A Life of Adventure in Immunobiology

Abstract

This article outlines my early start in medicine, a late start in immunology research, and my efforts to integrate the two activities. I first describe some of the background information, excitement, and implications of the recognition of T and B cells as separate but functionally intertwined arms of the adaptive immune system. The article continues with a brief account of my colleagues' and my efforts to use the model of hematopoietic stem cell differentiation along T and B cell lines to gain a better understanding of immunodeficiency diseases and lymphoid malignancies. It concludes with the discovery of a more ancient adaptive immune system in which T-like and B-like cells in jawless vertebrates use variable lymphocyte receptors constructed with leucine-rich-repeat sequences to recognize antigens.

Keyword(s): Autobiography, evolution of adaptive immunity, immunodeficiency diseases, lymphocytic malignancies, T and B cell development, variable lymphocyte receptors
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2009-04-23
2024-04-23
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