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Annual Review of Immunology

Volume 35, 2017

Understanding Human Autoimmunity and Autoinflammation Through Transcriptomics

Abstract

Transcriptomics, the high-throughput characterization of RNAs, has been instrumental in defining pathogenic signatures in human autoimmunity and autoinflammation. It enabled the identification of new therapeutic targets in IFN-, IL-1- and IL-17-mediated diseases. Applied to immunomonitoring, transcriptomics is starting to unravel diagnostic and prognostic signatures that stratify patients, track molecular changes associated with disease activity, define personalized treatment strategies, and generally inform clinical practice. Herein, we review the use of transcriptomics to define mechanistic, diagnostic, and predictive signatures in human autoimmunity and autoinflammation. We discuss some of the analytical approaches applied to extract biological knowledge from high-dimensional data sets. Finally, we touch upon emerging applications of transcriptomics to study eQTLs, B and T cell repertoire diversity, and isoform usage.

Keyword(s): autoimmunity, autoinflammation, mechanisms, patient stratification, therapeutic targets, transcriptomics
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/content/journals/10.1146/annurev-immunol-051116-052225
2017-04-26
2024-04-20
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Understanding Human Autoimmunity and Autoinflammation Through Transcriptomics
Annual Review of Immunology 35, 337 (2017); https://doi.org/10.1146/annurev-immunol-051116-052225
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