1932

Abstract

Humans have considerable genetic variation, as shown by their DNA sequence differences. Drug responsiveness and toxicity are affected by this variability. Genetic variation affects prodrug activation, drug targets, downstream activation pathways, drug elimination, and toxicity activation. Molecular diagnostic methods have discovered the genetic basis of several of these “outlier” drug responses. By predicting a patient's response, such diagnostics can improve both the safety and efficacy of drugs. The article illustrates the matching of molecular diagnosis to drug therapy for improved patient outcomes.

Loading

Article metrics loading...

/content/journals/10.1146/annurev-med-011209-132719
2010-02-18
2024-03-28
Loading full text...

Full text loading...

/content/journals/10.1146/annurev-med-011209-132719
Loading
/content/journals/10.1146/annurev-med-011209-132719
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error