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Annual Review of Medicine

Volume 68, 2017

Oral Combination Therapies for Hepatitis C Virus Infection: Successes, Challenges, and Unmet Needs

Abstract

The current standard of care for the treatment of hepatitis C virus (HCV) consists of interferon-free direct-acting antiviral (DAA) regimens, including combinations of DAAs and fixed-dose combination pills. DAAs for HCV are likely to be heralded as one of medicine's greatest advancements. Viral eradication rates are pushing 100% for many HCV-infected populations, including patients with HIV/HCV coinfection, decompensated cirrhosis, liver and kidney transplants, and end-stage liver disease. We highlight the greatest successes of combination DAA therapies, discuss the ongoing challenges, and identify the remaining patient subgroups with unmet medical needs.

Keyword(s): decompensated cirrhosis, liver transplant, end-stage liver disease, HCV, direct-acting antiviral, HIV/HCV coinfection, kidney transplant
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/content/journals/10.1146/annurev-med-052915-015720
2017-01-14
2024-04-19
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/content/journals/10.1146/annurev-med-052915-015720
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Oral Combination Therapies for Hepatitis C Virus Infection: Successes, Challenges, and Unmet Needs
Annual Review of Medicine 68, 345 (2017); https://doi.org/10.1146/annurev-med-052915-015720
/content/journals/10.1146/annurev-med-052915-015720
/content/journals/10.1146/annurev-med-052915-015720
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  • Article Type: Review Article

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