1932

Abstract

To evaluate the associations between coffee and caffeine consumption and various health outcomes, we performed an umbrella review of the evidence from meta-analyses of observational studies and randomized controlled trials (RCTs). Of the 59 unique outcomes examined in the selected 112 meta-analyses of observational studies, coffee was associated with a probable decreased risk of breast, colorectal, colon, endometrial, and prostate cancers; cardiovascular disease and mortality; Parkinson's disease; and type-2 diabetes. Of the 14 unique outcomes examined in the 20 selected meta-analyses of observational studies, caffeine was associated with a probable decreased risk of Parkinson's disease and type-2 diabetes and an increased risk of pregnancy loss. Of the 12 unique acute outcomes examined in the selected 9 meta-analyses of RCTs, coffee was associated with a rise in serum lipids, but this result was affected by significant heterogeneity, and caffeine was associated with a rise in blood pressure. Given the spectrum of conditions studied and the robustness of many of the results, these findings indicate that coffee can be part of a healthful diet.

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2017-08-21
2024-03-29
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Literature Cited

  1. Bai K, Cai Q, Jiang Y, Lv L. 1.  2016. Coffee consumption and risk of hepatocellular carcinoma: a meta-analysis of eleven epidemiological studies. Onco Targets Ther 9:4369–75 [Google Scholar]
  2. Bohn SK, Blomhoff R, Paur I. 2.  2014. Coffee and cancer risk, epidemiological evidence, and molecular mechanisms. Mol. Nutr. Food Res. 58:915–30 [Google Scholar]
  3. Botelho F, Lunet N, Barros H. 3.  2006. Coffee and gastric cancer: systematic review and meta-analysis. Cad. Saude Publica 22:889–900 [Google Scholar]
  4. Braem MG, Onland-Moret NC, Schouten LJ, Tjonneland A, Hansen L. 4.  et al. 2012. Coffee and tea consumption and the risk of ovarian cancer: a prospective cohort study and updated meta-analysis. Am. J. Clin. Nutr. 95:1172–81 [Google Scholar]
  5. Bravi F, Bosetti C, Tavani A, Bagnardi V, Gallus S. 5.  et al. 2007. Coffee drinking and hepatocellular carcinoma risk: a meta-analysis. Hepatology 46:430–35 [Google Scholar]
  6. Bravi F, Bosetti C, Tavani A, Gallus S, La Vecchia C. 6.  2013. Coffee reduces risk for hepatocellular carcinoma: an updated meta-analysis. Clin. Gastroenterol. Hepatol. 11:1413–21 [Google Scholar]
  7. Bravi F, Scotti L, Bosetti C, Gallus S, Negri E. 7.  et al. 2009. Coffee drinking and endometrial cancer risk: a metaanalysis of observational studies. Am. J. Obstet. Gynecol. 200:130–35 [Google Scholar]
  8. Bravi F, Tavani A, Bosetti C, Boffetta P, La Vecchia C. 8.  2017. Coffee and the risk of hepatocellular carcinoma and chronic liver disease: a systematic review and meta-analysis of prospective studies. Eur. J. Cancer Prev. In press. http://dx.doi.org/10.1097/CEJ.0000000000000252 [Crossref]
  9. Brent RL, Christian MS, Diener RM. 9.  2011. Evaluation of the reproductive and developmental risks of caffeine. Birth Defects Res. B Dev. Reprod. Toxicol. 92:152–87 [Google Scholar]
  10. Brown OI, Allgar V, Wong KY. 10.  2016. Coffee reduces the risk of death after acute myocardial infarction: a meta-analysis. Coron. Artery Dis. 27:566–72 [Google Scholar]
  11. Buscemi S, Marventano S, Antoci M, Cagnetti A, Castorina G. 11.  et al. 2016. Coffee and metabolic impairment: an updated review of epidemiological studies. NFS J 3:1–7 [Google Scholar]
  12. Cai L, Ma D, Zhang Y, Liu Z, Wang P. 12.  2012. The effect of coffee consumption on serum lipids: a meta-analysis of randomized controlled trials. Eur. J. Clin. Nutr. 66:872–77 [Google Scholar]
  13. Caini S, Cattaruzza S, Bendinelli B, Tosti G, Masala G. 13.  et al. 2016. Coffee, tea and caffeine intake and the risk of non-melanoma skin cancer: a review of the literature and meta-analysis. Eur. J. Nutr. 56:1–12 [Google Scholar]
  14. Caldeira D, Martins C, Alves LB, Pereira H, Ferreira JJ, Costa J. 14.  2013. Caffeine does not increase the risk of atrial fibrillation: a systematic review and meta-analysis of observational studies. Heart 99:1383–89 [Google Scholar]
  15. Cao S, Liu L, Yin X, Wang Y, Liu J, Lu Z. 15.  2014. Coffee consumption and risk of prostate cancer: a meta-analysis of prospective cohort studies. Carcinogenesis 35:256–61 [Google Scholar]
  16. Chen J, Long S. 16.  2014. Tea and coffee consumption and risk of laryngeal cancer: a systematic review meta-analysis. PLOS ONE 9:e112006 [Google Scholar]
  17. Chen LW, Wu Y, Neelakantan N, Chong MF, Pan A, van Dam RM. 17.  2014. Maternal caffeine intake during pregnancy is associated with risk of low birth weight: a systematic review and dose-response meta-analysis. BMC Med 12:174 [Google Scholar]
  18. Chen LW, Wu Y, Neelakantan N, Chong MF, Pan A, van Dam RM. 18.  2016. Maternal caffeine intake during pregnancy and risk of pregnancy loss: a categorical and dose-response meta-analysis of prospective studies. Public Health Nutr 19:1233–44 [Google Scholar]
  19. Chen S, Teoh NC, Chitturi S, Farrell GC. 19.  2014. Coffee and non-alcoholic fatty liver disease: brewing evidence for hepatoprotection?. J. Gastroenterol. Hepatol. 29:435–41 [Google Scholar]
  20. Cheng J, Su H, Zhu R, Wang X, Peng M. 20.  et al. 2014. Maternal coffee consumption during pregnancy and risk of childhood acute leukemia: a metaanalysis. Am. J. Obstet. Gynecol. 210:151.e1–10 [Google Scholar]
  21. Cheng M, Hu Z, Lu X, Huang J, Gu D. 21.  2014. Caffeine intake and atrial fibrillation incidence: dose response meta-analysis of prospective cohort studies. Can. J. Cardiol. 30:448–54 [Google Scholar]
  22. Chiaffarino F, Bravi F, Cipriani S, Parazzini F, Ricci E. 22.  et al. 2014. Coffee and caffeine intake and risk of endometriosis: a meta-analysis. Eur. J. Nutr. 53:1573–79 [Google Scholar]
  23. Colussi G, De Ferrari ME, Brunati C, Civati G. 23.  2000. Medical prevention and treatment of urinary stones. J. Nephrol. 13:Suppl. 3S65–70 [Google Scholar]
  24. Cornelis MC, El-Sohemy A, Kabagambe EK, Campos H. 24.  2006. Coffee, CYP1A2 genotype, and risk of myocardial infarction. JAMA 295:1135–41 [Google Scholar]
  25. Costa J, Lunet N, Santos C, Santos J, Vaz-Carneiro A. 25.  2010. Caffeine exposure and the risk of Parkinson's disease: a systematic review and meta-analysis of observational studies. J. Alzheimers Dis. 20:Suppl. 1S221–38 [Google Scholar]
  26. Crippa A, Discacciati A, Larsson SC, Wolk A, Orsini N. 26.  2014. Coffee consumption and mortality from all causes, cardiovascular disease, and cancer: a dose-response meta-analysis. Am. J. Epidemiol. 180:763–75 [Google Scholar]
  27. Deng W, Yang H, Wang J, Cai J, Bai Z. 27.  et al. 2016. Coffee consumption and the risk of incident gastric cancer—a meta-analysis of prospective cohort studies. Nutr. Cancer 68:40–47 [Google Scholar]
  28. Ding M, Bhupathiraju SN, Chen M, van Dam RM, Hu FB. 28.  2014. Caffeinated and decaffeinated coffee consumption and risk of type 2 diabetes: a systematic review and a dose-response meta-analysis. Diabetes Care 37:569–86 [Google Scholar]
  29. Ding M, Bhupathiraju SN, Satija A, van Dam RM, Hu FB. 29.  2014. Long-term coffee consumption and risk of cardiovascular disease: a systematic review and a dose-response meta-analysis of prospective cohort studies. Circulation 129:643–59 [Google Scholar]
  30. Discacciati A, Orsini N, Wolk A. 30.  2014. Coffee consumption and risk of nonaggressive, aggressive and fatal prostate cancer—a dose-response meta-analysis. Ann. Oncol. 25:584–91 [Google Scholar]
  31. Dong J, Zou J, Yu XF. 31.  2011. Coffee drinking and pancreatic cancer risk: a meta-analysis of cohort studies. World J. Gastroenterol. 17:1204–10 [Google Scholar]
  32. Galarraga V, Boffetta P. 32.  2016. Coffee drinking and risk of lung cancer—a meta-analysis. Cancer Epidemiol. Biomarkers Prev. 25:951–57 [Google Scholar]
  33. Galeone C, Turati F, La Vecchia C, Tavani A. 33.  2010. Coffee consumption and risk of colorectal cancer: a meta-analysis of case-control studies. Cancer Causes Control 21:1949–59 [Google Scholar]
  34. Gan Y, Wu J, Zhang S, Li L, Cao S. 34.  et al. 2017. Association of coffee consumption with risk of colorectal cancer: a meta-analysis of prospective cohort studies. Oncotarget 8:18699–711 [Google Scholar]
  35. Giovannucci E. 35.  1998. Meta-analysis of coffee consumption and risk of colorectal cancer. Am. J. Epidemiol. 147:1043–52 [Google Scholar]
  36. Godos J, Pluchinotta FR, Marventano S, Buscemi S, Li Volti G. 36.  et al. 2014. Coffee components and cardiovascular risk: beneficial and detrimental effects. Int. J. Food Sci. Nutr. 65:925–36 [Google Scholar]
  37. Greenland S. 37.  1993. A meta-analysis of coffee, myocardial infarction, and coronary death. Epidemiology 4:366–74 [Google Scholar]
  38. Greenwood DC, Thatcher NJ, Ye J, Garrard L, Keogh G. 38.  et al. 2014. Caffeine intake during pregnancy and adverse birth outcomes: a systematic review and dose-response meta-analysis. Eur. J. Epidemiol. 29:725–34 [Google Scholar]
  39. Grosso G, Micek A, Castellano S, Pajak A, Galvano F. 39.  2016. Coffee, tea, caffeine and risk of depression: a systematic review and dose-response meta-analysis of observational studies. Mol. Nutr. Food Res. 60:223–34 [Google Scholar]
  40. Hernan MA, Takkouche B, Caamano-Isorna F, Gestal-Otero JJ. 40.  2002. A meta-analysis of coffee drinking, cigarette smoking, and the risk of Parkinson's disease. Ann. Neurol. 52:276–84 [Google Scholar]
  41. Higdon JV, Frei B. 41.  2006. Coffee and health: a review of recent human research. Crit. Rev. Food Sci. Nutr. 46:101–23 [Google Scholar]
  42. Higgins LG, Cavin C, Itoh K, Yamamoto M, Hayes JD. 42.  2008. Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein. Toxicol. Appl. Pharmacol. 226:328–37 [Google Scholar]
  43. Huang TB, Guo ZF, Zhang XL, Zhang XP, Liu H. 43.  et al. 2014. Coffee consumption and urologic cancer risk: a meta-analysis of cohort studies. Int. Urol. Nephrol. 46:1481–93 [Google Scholar]
  44. Huber WW, Parzefall W. 44.  2005. Modification of N-acetyltransferases and glutathione S-transferases by coffee components: possible relevance for cancer risk. Methods Enzymol. 401:307–41 [Google Scholar]
  45. Huxley R, Lee CM, Barzi F, Timmermeister L, Czernichow S. 45.  et al. 2009. Coffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus: a systematic review with meta-analysis. Arch. Intern. Med. 169:2053–63 [Google Scholar]
  46. Inoue M, Tsugane S. 46.  2012. Insulin resistance and cancer: epidemiological evidence. Endocr. Relat. Cancer 19:F1–8 [Google Scholar]
  47. Jahanfar S, Jaafar SH. 47.  2015. Effects of restricted caffeine intake by mother on fetal, neonatal and pregnancy outcome. Cochrane Database Syst. Rev. 6:CD006965 [Google Scholar]
  48. Je Y, Giovannucci E. 48.  2012. Coffee consumption and risk of endometrial cancer: findings from a large up-to-date meta-analysis. Int. J. Cancer 131:1700–10 [Google Scholar]
  49. Je Y, Giovannucci E. 49.  2014. Coffee consumption and total mortality: a meta-analysis of twenty prospective cohort studies. Br. J. Nutr. 111:1162–73 [Google Scholar]
  50. Je Y, Liu W, Giovannucci E. 50.  2009. Coffee consumption and risk of colorectal cancer: a systematic review and meta-analysis of prospective cohort studies. Int. J. Cancer 124:1662–68 [Google Scholar]
  51. Jee SH, He J, Whelton PK, Suh I, Klag MJ. 51.  1999. The effect of chronic coffee drinking on blood pressure: a meta-analysis of controlled clinical trials. Hypertension 33:647–52 [Google Scholar]
  52. Jiang W, Wu Y, Jiang X. 52.  2013. Coffee and caffeine intake and breast cancer risk: an updated dose-response meta-analysis of 37 published studies. Gynecol. Oncol. 129:620–29 [Google Scholar]
  53. Jiang X, Zhang D, Jiang W. 53.  2014. Coffee and caffeine intake and incidence of type 2 diabetes mellitus: a meta-analysis of prospective studies. Eur. J. Nutr. 53:25–38 [Google Scholar]
  54. Kawachi I, Colditz GA, Stone CB. 54.  1994. Does coffee drinking increase the risk of coronary heart disease? Results from a meta-analysis. Br. Heart J. 72:269–75 [Google Scholar]
  55. Kennedy OJ, Roderick P, Buchanan R, Fallowfield JA, Hayes PC, Parkes J. 55.  2016. Systematic review with meta-analysis: coffee consumption and the risk of cirrhosis. Aliment. Pharmacol. Ther. 43:562–74 [Google Scholar]
  56. Kim B, Nam Y, Kim J, Choi H, Won C. 56.  2012. Coffee consumption and stroke risk: a meta-analysis of epidemiologic studies. Korean J. Fam. Med. 33:356–65 [Google Scholar]
  57. Kim J, Oh SW, Myung SK, Kwon H, Lee C. 57.  et al. 2014. Association between coffee intake and gastro-esophageal reflux disease: a meta-analysis. Dis. Esophagus 27:311–17 [Google Scholar]
  58. Kim YS, Kwak SM, Myung SK. 58.  2015. Caffeine intake from coffee or tea and cognitive disorders: a meta-analysis of observational studies. Neuroepidemiology 44:51–63 [Google Scholar]
  59. Kua KP, Lee SW. 59.  2017. Systematic review and meta-analysis of clinical outcomes of early caffeine therapy in preterm neonates. Br. J. Clin. Pharmacol. 83:180–191 [Google Scholar]
  60. Larsson SC, Drca N, Jensen-Urstad M, Wolk A. 60.  2015. Coffee consumption is not associated with increased risk of atrial fibrillation: results from two prospective cohorts and a meta-analysis. BMC Med 13:207 [Google Scholar]
  61. Larsson SC, Orsini N. 61.  2011. Coffee consumption and risk of stroke: a dose-response meta-analysis of prospective studies. Am. J. Epidemiol. 174:993–1001 [Google Scholar]
  62. Larsson SC, Wolk A. 62.  2007. Coffee consumption and risk of liver cancer: a meta-analysis. Gastroenterology 132:1740–45 [Google Scholar]
  63. Lee DR, Lee J, Rota M, Lee J, Ahn HS. 63.  et al. 2014. Coffee consumption and risk of fractures: a systematic review and dose-response meta-analysis. Bone 63:20–28 [Google Scholar]
  64. Lee YH, Bae SC, Song GG. 64.  2014. Coffee or tea consumption and the risk of rheumatoid arthritis: a meta-analysis. Clin. Rheumatol. 33:1575–83 [Google Scholar]
  65. Li G, Ma D, Zhang Y, Zheng W, Wang P. 65.  2013. Coffee consumption and risk of colorectal cancer: a meta-analysis of observational studies. Public Health Nutr 16:346–57 [Google Scholar]
  66. Li J, Zhao H, Song JM, Zhang J, Tang YL, Xin CM. 66.  2015. A meta-analysis of risk of pregnancy loss and caffeine and coffee consumption during pregnancy. Int. J. Gynaecol. Obstet. 130:116–22 [Google Scholar]
  67. Li L, Gan Y, Wu C, Qu X, Sun G, Lu Z. 67.  2015. Coffee consumption and the risk of gastric cancer: a meta-analysis of prospective cohort studies. BMC Cancer 15:733 [Google Scholar]
  68. Li S, Dai Z, Wu Q. 68.  2015. Effect of coffee intake on hip fracture: a meta-analysis of prospective cohort studies. Nutr. J. 14:38 [Google Scholar]
  69. Li XJ, Ren ZJ, Qin JW, Zhao JH, Tang JH. 69.  et al. 2013. Coffee consumption and risk of breast cancer: an up-to-date meta-analysis. PLOS ONE 8:e52681 [Google Scholar]
  70. Li XL, Xu JH. 70.  2013. Coffee consumption and hip fracture risk: a meta-analysis. J. Nutr. Sci. 2:e23 [Google Scholar]
  71. Li YM, Peng J, Li LZ. 71.  2016. Coffee consumption associated with reduced risk of oral cancer: a meta-analysis. Oral Surg. Oral Med. Oral Pathol. Oral Radiol 121381–89 [Google Scholar]
  72. Li ZX, Gao ZL, Wang JN, Guo QH. 72.  2016. Maternal coffee consumption during pregnancy and neural tube defects in offspring: a meta-analysis. Fetal Pediatr. Pathol. 35:1–9 [Google Scholar]
  73. Lippi G, Mattiuzzi C, Franchini M. 73.  2015. Venous thromboembolism and coffee: critical review and meta-analysis. Ann. Transl. Med. 3:152 [Google Scholar]
  74. Liu F, Wang X, Wu G, Chen L, Hu P. 74.  et al. 2015. Coffee consumption decreases risks for hepatic fibrosis and cirrhosis: a meta-analysis. PLOS ONE 10:e0142457 [Google Scholar]
  75. Liu H, Hu GH, Wang XC, Huang TB, Xu L. 75.  et al. 2015. Coffee consumption and prostate cancer risk: a meta-analysis of cohort studies. Nutr. Cancer 67:392–400 [Google Scholar]
  76. Liu H, Hua Y, Zheng X, Shen Z, Luo H. 76.  et al. 2015. Effect of coffee consumption on the risk of gastric cancer: a systematic review and meta-analysis of prospective cohort studies. PLOS ONE 10:e0128501 [Google Scholar]
  77. Liu H, Yao K, Zhang W, Zhou J, Wu T, He C. 77.  2012. Coffee consumption and risk of fractures: a meta-analysis. Arch. Med. Sci 8776–83 [Google Scholar]
  78. Liu J, Shen B, Shi M, Cai J. 78.  2016. Higher caffeinated coffee intake is associated with reduced malignant melanoma risk: a meta-analysis study. PLOS ONE 11:e0147056 [Google Scholar]
  79. Liu QP, Wu YF, Cheng HY, Xia T, Ding H. 79.  et al. 2016. Habitual coffee consumption and risk of cognitive decline/dementia: a systematic review and meta-analysis of prospective cohort studies. Nutrition 32:628–36 [Google Scholar]
  80. Liu R, Guo X, Park Y, Huang X, Sinha R. 80.  et al. 2012. Caffeine intake, smoking, and risk of Parkinson disease in men and women. Am. J. Epidemiol. 175:1200–7 [Google Scholar]
  81. Lu Y, Zhai L, Zeng J, Peng Q, Wang J. 81.  et al. 2014. Coffee consumption and prostate cancer risk: an updated meta-analysis. Cancer Causes Control 25:591–604 [Google Scholar]
  82. Ludwig IA, Clifford MN, Lean ME, Ashihara H, Crozier A. 82.  2014. Coffee: biochemistry and potential impact on health. Food Funct 5:1695–717 [Google Scholar]
  83. Malerba S, Galeone C, Pelucchi C, Turati F, Hashibe M. 83.  et al. 2013. A meta-analysis of coffee and tea consumption and the risk of glioma in adults. Cancer Causes Control 24:267–76 [Google Scholar]
  84. Malerba S, Turati F, Galeone C, Pelucchi C, Verga F. 84.  et al. 2013. A meta-analysis of prospective studies of coffee consumption and mortality for all causes, cancers and cardiovascular diseases. Eur. J. Epidemiol. 28:527–39 [Google Scholar]
  85. Martini D, Del Bo C, Tassotti M, Riso P, Del Rio D. 85.  et al. 2016. Coffee consumption and oxidative stress: a review of human intervention studies. Molecules 21:979 [Google Scholar]
  86. Marventano S, Salomone F, Godos J, Pluchinotta F, Del Rio D. 86.  et al. 2016. Coffee and tea consumption in relation with non-alcoholic fatty liver and metabolic syndrome: a systematic review and meta-analysis of observational studies. Clin. Nutr. 35:1269–81 [Google Scholar]
  87. Meng S, Cao J, Feng Q, Peng J, Hu Y. 87.  2013. Roles of chlorogenic acid on regulating glucose and lipids metabolism: a review. Evid. Based Complement. Altern. Med. 2013:801457 [Google Scholar]
  88. Mesas AE, Leon-Munoz LM, Rodriguez-Artalejo F, Lopez-Garcia E. 88.  2011. The effect of coffee on blood pressure and cardiovascular disease in hypertensive individuals: a systematic review and meta-analysis. Am. J. Clin. Nutr. 94:1113–26 [Google Scholar]
  89. Milne E, Royle JA, Bennett LC, de Klerk NH, Bailey HD. 89.  et al. 2011. Maternal consumption of coffee and tea during pregnancy and risk of childhood ALL: results from an Australian case-control study. Cancer Causes Control 22:207–18 [Google Scholar]
  90. Moco S, Martin FP, Rezzi S. 90.  2012. Metabolomics view on gut microbiome modulation by polyphenol-rich foods. J. Proteome Res. 11:4781–90 [Google Scholar]
  91. Moreira AS, Nunes FM, Domingues MR, Coimbra MA. 91.  2012. Coffee melanoidins: structures, mechanisms of formation and potential health impacts. Food Funct 3:903–15 [Google Scholar]
  92. Mostofsky E, Rice MS, Levitan EB, Mittleman MA. 92.  2012. Habitual coffee consumption and risk of heart failure: a dose-response meta-analysis. Circ. Heart Fail. 5:401–5 [Google Scholar]
  93. Mulak A, Bonaz B. 93.  2015. Brain–gut–microbiota axis in Parkinson's disease. World J. Gastroenterol. 21:10609–20 [Google Scholar]
  94. Myers MG, Basinski A. 94.  1992. Coffee and coronary heart disease. Arch. Intern. Med. 152:1767–72 [Google Scholar]
  95. Nehlig A. 95.  2016. Effects of coffee/caffeine on brain health and disease: What should I tell my patients?. Pract. Neurol. 16:89–95 [Google Scholar]
  96. Nie K, Xing Z, Huang W, Wang W, Liu W. 96.  2016. Coffee intake and risk of pancreatic cancer: an updated meta-analysis of prospective studies. Minerva Med 107:270–78 [Google Scholar]
  97. Noordzij M, Uiterwaal CS, Arends LR, Kok FJ, Grobbee DE, Geleijnse JM. 97.  2005. Blood pressure response to chronic intake of coffee and caffeine: a meta-analysis of randomized controlled trials. J. Hypertens. 23:921–28 [Google Scholar]
  98. Ouyang Z, Wang Z, Jin J. 98.  2014. Association between tea and coffee consumption and risk of laryngeal cancer: a meta-analysis. Int. J. Clin. Exp. Med. 7:5192–200 [Google Scholar]
  99. Palatini P, Ceolotto G, Ragazzo F, Dorigatti F, Saladini F. 99.  et al. 2009. CYP1A2 genotype modifies the association between coffee intake and the risk of hypertension. J. Hypertens. 27:1594–601 [Google Scholar]
  100. Pan MH, Tung YC, Yang G, Li S, Ho CT. 100.  2016. Molecular mechanisms of the anti-obesity effect of bioactive compounds in tea and coffee. Food Funct 7:4481–91 [Google Scholar]
  101. Park CH, Myung SK, Kim TY, Seo HG, Jeon YJ. 101.  et al. 2010. Coffee consumption and risk of prostate cancer: a meta-analysis of epidemiological studies. BJU Int 106:762–69 [Google Scholar]
  102. Park KY, Kim HJ, Ahn HS, Kim SH, Park EJ. 102.  et al. 2016. Effects of coffee consumption on serum uric acid: systematic review and meta-analysis. Semin. Arthritis Rheum. 45:580–86 [Google Scholar]
  103. Qi H, Li S. 103.  2014. Dose-response meta-analysis on coffee, tea and caffeine consumption with risk of Parkinson's disease. Geriatr. Gerontol. Int. 14:430–39 [Google Scholar]
  104. Ran HQ, Wang JZ, Sun CQ. 104.  2016. Coffee consumption and pancreatic cancer risk: an update meta-analysis of cohort studies. Pak. J. Med. Sci 32253–59 [Google Scholar]
  105. Ranheim T, Halvorsen B. 105.  2005. Coffee consumption and human health–beneficial or detrimental? Mechanisms for effects of coffee consumption on different risk factors for cardiovascular disease and type 2 diabetes mellitus. Mol. Nutr. Food Res. 49:274–84 [Google Scholar]
  106. Rhee J, Kim R, Kim Y, Tam M, Lai Y. 106.  et al. 2015. Maternal caffeine consumption during pregnancy and risk of low birth weight: a dose-response meta-analysis of observational studies. PLOS ONE 10:e0132334 [Google Scholar]
  107. Saab S, Mallam D, Cox GA 2nd, Tong MJ. 107.  2014. Impact of coffee on liver diseases: a systematic review. Liver Int 34:495–504 [Google Scholar]
  108. Sang LX, Chang B, Li XH, Jiang M. 108.  2013. Consumption of coffee associated with reduced risk of liver cancer: a meta-analysis. BMC Gastroenterol 13:34 [Google Scholar]
  109. Santos C, Costa J, Santos J, Vaz-Carneiro A, Lunet N. 109.  2010. Caffeine intake and dementia: systematic review and meta-analysis. J. Alzheimers Dis. 20:Suppl. 1S187–204 [Google Scholar]
  110. Shaffer EA. 110.  2006. Gallstone disease: epidemiology of gallbladder stone disease. Best Pract. Res. Clin. Gastroenterol. 20:981–96 [Google Scholar]
  111. Shang F, Li X, Jiang X. 111.  2016. Coffee consumption and risk of the metabolic syndrome: a meta-analysis. Diabetes Metab 42:80–87 [Google Scholar]
  112. Shen Z, Liu H, Cao H. 112.  2015. Coffee consumption and risk of gastric cancer: an updated meta-analysis. Clin. Res. Hepatol. Gastroenterol. 39:245–53 [Google Scholar]
  113. Sheng J, Qu X, Zhang X, Zhai Z, Li H. 113.  et al. 2014. Coffee, tea, and the risk of hip fracture: a meta-analysis. Osteoporos. Int. 25:141–50 [Google Scholar]
  114. Shimamoto T, Yamamichi N, Kodashima S, Takahashi Y, Fujishiro M. 114.  et al. 2013. No association of coffee consumption with gastric ulcer, duodenal ulcer, reflux esophagitis, and non-erosive reflux disease: a cross-sectional study of 8,013 healthy subjects in Japan. PLOS ONE 8:e65996 [Google Scholar]
  115. Sofi F, Conti AA, Gori AM, Eliana Luisi ML, Casini A. 115.  et al. 2007. Coffee consumption and risk of coronary heart disease: a meta-analysis. Nutr. Metab. Cardiovasc. Dis. 17:209–23 [Google Scholar]
  116. Steevens J, Schouten LJ, Verhage BA, Goldbohm RA, van den Brandt PA. 116.  2007. Tea and coffee drinking and ovarian cancer risk: results from the Netherlands Cohort Study and a meta-analysis. Br. J. Cancer 97:1291–94 [Google Scholar]
  117. Steffen M, Kuhle C, Hensrud D, Erwin PJ, Murad MH. 117.  2012. The effect of coffee consumption on blood pressure and the development of hypertension: a systematic review and meta-analysis. J. Hypertens. 30:2245–54 [Google Scholar]
  118. Tang N, Wu Y, Ma J, Wang B, Yu R. 118.  2010. Coffee consumption and risk of lung cancer: a meta-analysis. Lung Cancer 67:17–22 [Google Scholar]
  119. Tang N, Zhou B, Wang B, Yu R. 119.  2009. Coffee consumption and risk of breast cancer: a metaanalysis. Am. J. Obstet. Gynecol. 200:290.e1–9 [Google Scholar]
  120. Thomopoulos TP, Ntouvelis E, Diamantaras AA, Tzanoudaki M, Baka M. 120.  et al. 2015. Maternal and childhood consumption of coffee, tea and cola beverages in association with childhood leukemia: a meta-analysis. Cancer Epidemiol 39:1047–59 [Google Scholar]
  121. Tian C, Wang W, Hong Z, Zhang X. 121.  2013. Coffee consumption and risk of colorectal cancer: a dose-response analysis of observational studies. Cancer Causes Control 24:1265–68 [Google Scholar]
  122. Timms JA, Relton CL, Rankin J, Strathdee G, McKay JA. 122.  2016. DNA methylation as a potential mediator of environmental risks in the development of childhood acute lymphoblastic leukemia. Epigenomics 8:519–36 [Google Scholar]
  123. Turati F, Galeone C, Edefonti V, Ferraroni M, Lagiou P. 123.  et al. 2012. A meta-analysis of coffee consumption and pancreatic cancer. Ann. Oncol. 23:311–18 [Google Scholar]
  124. Turati F, Galeone C, La Vecchia C, Garavello W, Tavani A. 124.  2011. Coffee and cancers of the upper digestive and respiratory tracts: meta-analyses of observational studies. Ann. Oncol. 22:536–44 [Google Scholar]
  125. Vitaglione P, Fogliano V, Pellegrini N. 125.  2012. Coffee, colon function and colorectal cancer. Food Funct 3:916–22 [Google Scholar]
  126. Wang J, Li X, Zhang D. 126.  2016. Coffee consumption and the risk of cutaneous melanoma: a meta-analysis. Eur. J. Nutr. 55:1317–29 [Google Scholar]
  127. Wang L, Shen X, Wu Y, Zhang D. 127.  2016. Coffee and caffeine consumption and depression: a meta-analysis of observational studies. Aust. N. Z. J. Psychiatry 50:228–42 [Google Scholar]
  128. Wang S, Zhang Y, Mao Z, He X, Zhang Q, Zhang D. 128.  2014. A meta-analysis of coffee intake and risk of urolithiasis. Urol. Int. 93:220–28 [Google Scholar]
  129. Wang Y, Yu X, Wu Y, Zhang D. 129.  2012. Coffee and tea consumption and risk of lung cancer: a dose-response analysis of observational studies. Lung Cancer 78:169–70 [Google Scholar]
  130. Welsh EJ, Bara A, Barley E, Cates CJ. 130.  2010. Caffeine for asthma. Cochrane Database Syst. Rev. 1:CD001112 [Google Scholar]
  131. 131. World Health Organization. Population nutrient intake goals for preventing diet-related chronic diseases http://www.who.int/nutrition/topics/5_population_nutrient/en/. Accessed November 2015 Geneva: WHO
  132. Wu JN, Ho SC, Zhou C, Ling WH, Chen WQ. 132.  et al. 2009. Coffee consumption and risk of coronary heart diseases: a meta-analysis of 21 prospective cohort studies. Int. J. Cardiol. 137:216–25 [Google Scholar]
  133. Wu L, Sun D, He Y. 133.  2017. Coffee intake and the incident risk of cognitive disorders: a dose-response meta-analysis of nine prospective cohort studies. Clin. Nutr. 36:3730–36 [Google Scholar]
  134. Wu W, Tong Y, Zhao Q, Yu G, Wei X, Lu Q. 134.  2015. Coffee consumption and bladder cancer: a meta-analysis of observational studies. Sci. Rep. 5:9051 [Google Scholar]
  135. Xie F, Wang D, Huang Z, Guo Y. 135.  2014. Coffee consumption and risk of gastric cancer: a large updated meta-analysis of prospective studies. Nutrients 6:3734–46 [Google Scholar]
  136. Xie Y, Huang S, He T, Su Y. 136.  2016. Coffee consumption and risk of gastric cancer: an updated meta-analysis. Asia Pac. J. Clin. Nutr. 25:578–88 [Google Scholar]
  137. Xie Y, Qin J, Nan G, Huang S, Wang Z, Su Y. 137.  2016. Coffee consumption and the risk of lung cancer: an updated meta-analysis of epidemiological studies. Eur. J. Clin. Nutr. 70:199–206 [Google Scholar]
  138. Xu C, Zhang C, Wang XL, Liu TZ, Zeng XT. 138.  et al. 2015. Self-fluid management in prevention of kidney stones: a PRISMA-compliant systematic review and dose-response meta-analysis of observational studies. Medicine 94:e1042 [Google Scholar]
  139. Yang TO, Crowe F, Cairns BJ, Reeves GK, Beral V. 139.  2015. Tea and coffee and risk of endometrial cancer: cohort study and meta-analysis. Am. J. Clin. Nutr. 101:570–78 [Google Scholar]
  140. Yew YW, Lai YC, Schwartz RA. 140.  2016. Coffee consumption and melanoma: a systematic review and meta-analysis of observational studies. Am. J. Clin. Dermatol. 17:113–23 [Google Scholar]
  141. Yu X, Bao Z, Zou J, Dong J. 141.  2011. Coffee consumption and risk of cancers: a meta-analysis of cohort studies. BMC Cancer 11:96 [Google Scholar]
  142. Zeegers MP, Tan FE, Goldbohm RA, van den Brandt PA. 142.  2001. Are coffee and tea consumption associated with urinary tract cancer risk? A systematic review and meta-analysis. Int. J. Epidemiol. 30:353–62 [Google Scholar]
  143. Zeng SB, Weng H, Zhou M, Duan XL, Shen XF, Zeng XT. 143.  2015. Long-term coffee consumption and risk of gastric cancer: a PRISMA-compliant dose-response meta-analysis of prospective cohort studies. Medicine 94:e1640 [Google Scholar]
  144. Zhang X, Albanes D, Beeson WL, van den Brandt PA, Buring JE. 144.  et al. 2010. Risk of colon cancer and coffee, tea, and sugar-sweetened soft drink intake: pooled analysis of prospective cohort studies. J. Natl. Cancer Inst. 102:771–83 [Google Scholar]
  145. Zhang Y, Lee ET, Cowan LD, Fabsitz RR, Howard BV. 145.  2011. Coffee consumption and the incidence of type 2 diabetes in men and women with normal glucose tolerance: the Strong Heart Study. Nutr. Metab. Cardiovasc. Dis. 21:418–23 [Google Scholar]
  146. Zhang Y, Wang X, Cui D. 146.  2015. Association between coffee consumption and the risk of oral cancer: a meta-analysis of observational studies. Int. J. Clin. Exp. Med. 8:11657–65 [Google Scholar]
  147. Zhang Y, Yang T, Zeng C, Wei J, Li H. 147.  et al. 2016. Is coffee consumption associated with a lower risk of hyperuricaemia or gout? A systematic review and meta-analysis. BMJ Open 6:e009809 [Google Scholar]
  148. Zhang YP, Li WQ, Sun YL, Zhu RT, Wang WJ. 148.  2015. Systematic review with meta-analysis: coffee consumption and the risk of gallstone disease. Aliment. Pharmacol. Ther. 42:637–48 [Google Scholar]
  149. Zhao Y, Wu K, Zheng J, Zuo R, Li D. 149.  2015. Association of coffee drinking with all-cause mortality: a systematic review and meta-analysis. Public Health Nutr 18:1282–91 [Google Scholar]
  150. Zheng JS, Yang J, Fu YQ, Huang T, Huang YJ, Li D. 150.  2013. Effects of green tea, black tea, and coffee consumption on the risk of esophageal cancer: a systematic review and meta-analysis of observational studies. Nutr. Cancer 65:1–16 [Google Scholar]
  151. Zhong S, Chen W, Yu X, Chen Z, Hu Q, Zhao J. 151.  2014. Coffee consumption and risk of prostate cancer: an up-to-date meta-analysis. Eur. J. Clin. Nutr. 68:330–37 [Google Scholar]
  152. Zhou J, Zhou S, Zeng S. 152.  2013. Experimental diabetes treated with trigonelline: effect on β cell and pancreatic oxidative parameters. Fundam. Clin. Pharmacol. 27:279–87 [Google Scholar]
  153. Zhou Q, Luo ML, Li H, Li M, Zhou JG. 153.  2015. Coffee consumption and risk of endometrial cancer: a dose-response meta-analysis of prospective cohort studies. Sci. Rep. 5:13410 [Google Scholar]
  154. Zhou Y, Tian C, Jia C. 154.  2012. A dose-response meta-analysis of coffee consumption and bladder cancer. Prev. Med. 55:14–22 [Google Scholar]
  155. Zuchinali P, Ribeiro PA, Pimentel M, da Rosa PR, Zimerman LI, Rohde LE. 155.  2016. Effect of caffeine on ventricular arrhythmia: a systematic review and meta-analysis of experimental and clinical studies. Europace 18:257–66 [Google Scholar]
  156. Zulli A, Smith RM, Kubatka P, Novak J, Uehara Y. 156.  et al. 2016. Caffeine and cardiovascular diseases: critical review of current research. Eur. J. Nutr. 55:1331–43 [Google Scholar]
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