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Annual Review of Pharmacology and Toxicology

Volume 56, 2016

Structure, Function, and Drug Interactions of Neurotransmitter Transporters in the Postgenomic Era

Abstract

Vesicular neurotransmitter transporters are responsible for the accumulation of neurotransmitters in secretory vesicles and play essential roles in chemical transmission. The SLC17 family contributes to sequestration of anionic neurotransmitters such as glutamate, aspartate, and nucleotides. Identification and subsequent cellular and molecular biological studies of SLC17 transporters unveiled the principles underlying the actions of these transporters. Recent progress in reconstitution methods in combination with postgenomic approaches has advanced studies on neurotransmitter transporters. This review summarizes the molecular properties of SLC17-type transporters and recent findings regarding the novel SLC18 transporter.

Keyword(s): purification, reconstitution, SLC17, transporter, vesicular neurotransmitter transporter
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2016-01-06
2024-04-20
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Structure, Function, and Drug Interactions of Neurotransmitter Transporters in the Postgenomic Era
Annual Review of Pharmacology and Toxicology 56, 385 (2016); https://doi.org/10.1146/annurev-pharmtox-010814-124816
/content/journals/10.1146/annurev-pharmtox-010814-124816
/content/journals/10.1146/annurev-pharmtox-010814-124816
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