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Annual Review of Physiology

Volume 77, 2015

Intrinsic and Extrinsic Mechanisms of Dendritic Morphogenesis

Abstract

The complex, branched morphology of dendrites is a cardinal feature of neurons and has been used as a criterion for cell type identification since the beginning of neurobiology. Regulated dendritic outgrowth and branching during development form the basis of receptive fields for neurons and are essential for the wiring of the nervous system. The cellular and molecular mechanisms of dendritic morphogenesis have been an intensely studied area. In this review, we summarize the major experimental systems that have contributed to our understandings of dendritic development as well as the intrinsic and extrinsic mechanisms that instruct the neurons to form cell type–specific dendritic arbors.

Keyword(s): branching, dendrite, development, neuron, receptor-ligand interaction, self-avoidance, transcriptional regulation
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/content/journals/10.1146/annurev-physiol-021014-071746
2015-02-10
2024-04-24
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Intrinsic and Extrinsic Mechanisms of Dendritic Morphogenesis
Annual Review of Physiology 77, 271 (2015); https://doi.org/10.1146/annurev-physiol-021014-071746
/content/journals/10.1146/annurev-physiol-021014-071746
/content/journals/10.1146/annurev-physiol-021014-071746
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