1932

Abstract

We examine evidence supporting the associations among physical activity (PA), cognitive vitality, neural functioning, and the moderation of these associations by genetic factors. Prospective epidemiological studies provide evidence for PA to be associated with a modest reduction in relative risk of cognitive decline. An evaluation of the PA-cognition link across the life span provides modest support for the effect of PA on preserving and even enhancing cognitive vitality and the associated neural circuitry in older adults, with the majority of benefits seen for tasks that are supported by the prefrontal cortex and the hippocampus. The literature on children and young adults, however, is in need of well-powered randomized controlled trials. Future directions include a more sophisticated understanding of the dose-response relationship, the integration of genetic and epigenetic approaches, inclusion of multimodal imaging of brain-behavior changes, and finally the design of multimodal interventions that may yield broader improvements in cognitive function.

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2015-01-03
2024-03-28
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Literature Cited

  1. Abel JL, Rissman EF. 2013. Running-induced epigenetic and gene expression changes in the adolescent brain. Int. J. Dev. Neurosci. 31:6382–90 [Google Scholar]
  2. Aberg MA, Pedersen NL, Toren K, Svartengren M, Backstrand B. et al. 2009. Cardiovascular fitness is associated with cognition in young adulthood. Proc. Natl. Acad. Sci. USA 106:4920906–11 [Google Scholar]
  3. Ahlskog JE, Geda YE, Graff-Radford NR, Petersen RC. 2011. Physical exercise as a preventive or disease-modifying treatment of dementia and brain aging. Mayo Clin. Proc. 86:9876–84 [Google Scholar]
  4. Almeida OP, Norman P, Hankey G, Jamrozik K, Flicker L. 2006. Successful mental health aging: results from a longitudinal study of older Australian men. Am. J. Geriatr. Psychiatry 14:127–35 [Google Scholar]
  5. Andrews-Hanna JR, Reidler JS, Sepulcre J, Poulin R, Buckner RL. 2010. Functional-anatomic fractionation of the brain's default network. Neuron 65:4550–62 [Google Scholar]
  6. Angevaren M, Aufdemkampe G, Verhaar H, Aleman A, Vanhees L. 2008. Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment. Cochrane Database Syst. Rev. 16:2CD005381 [Google Scholar]
  7. Ashburner I, Friston KJ. 2000. Voxel-based morphometry—the methods. NeuroImage 11:805–21 [Google Scholar]
  8. Atkinson HH, Rosano C, Simonsick EM, Williamson JD, Davis C. et al. 2007. Cognitive function, gait speed decline, and comorbidities: the health, aging and body composition study. J. Gerontol. A Biol. Sci. Med. Sci. 62:8844–50 [Google Scholar]
  9. Baker LD, Frank LL, Foster-Schubert K, Green PS, Wilkinson CW. et al. 2010. Effects of aerobic exercise on mild cognitive impairment: a controlled trial. Arch. Neurol. 67:171–79 [Google Scholar]
  10. Beebe LH, Tian L, Morris N, Goodwin A, Allen SS, Kuldau J. 2005. Effects of exercise on mental and physical health parameters of persons with schizophrenia. Issues Ment. Health Nurs. 26:6661–76 [Google Scholar]
  11. Black JE, Isaacs KR, Anderson BJ, Alcantara AA, Greenough WT. 1990. Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats. Proc. Natl. Acad. Sci. USA 87:145568–72 [Google Scholar]
  12. Bressler SL, Menon V. 2010. Large-scale brain networks in cognition: emerging methods and principles. Trends Cogn. Sci. 14:6277–90 [Google Scholar]
  13. Briken S, Gold S, Patra S, Vettorazzi E, Harbs D. et al. 2014. Effects of exercise on fitness and cognition in progressive MS: a randomized, controlled pilot trial. Mult. Scler. J. 20:3382–90 [Google Scholar]
  14. Buchman AS, Boyle PA, Yu L, Shah RC, Wilson RS, Bennett DA. 2012. Total daily physical activity and the risk of AD and cognitive decline in older adults. Neurology 78:171323–29 [Google Scholar]
  15. Buckner RL, Andrews-Hanna JR, Schacter DL. 2008. The brain's default network: anatomy, function, and relevance to disease. Ann. N. Y. Acad. Sci. 1124:1–38 [Google Scholar]
  16. Bullmore E, Sporns O. 2009. Complex brain networks: graph theoretical analysis of structural and functional systems. Nat. Rev. Neurosci. 10:3186–98 [Google Scholar]
  17. Burdette JH, Laurienti PJ, Espeland MA, Morgan A, Telesford Q. et al. 2010. Using network science to evaluate exercise-associated brain changes in older adults. Front. Aging Neurosci. 2:23 [Google Scholar]
  18. Cabeza R. 2002. Hemispheric asymmetry reduction in older adults: the HAROLD model. Psychol. Aging 17:185–100 [Google Scholar]
  19. Carlson MC, Saczynski JS, Rebok GW, Seeman T, Glass TA. et al. 2008. Exploring the effects of an “everyday” activity program on executive function and memory in older adults: Experience Corps. Gerontologist 48:6793–801 [Google Scholar]
  20. Carro E, Nunez A, Busiguina S, Torres-Aleman I. 2000. Circulating insulin-like growth factor I mediates effects of exercise on the brain. J. Neurosci. 20:82926–33 [Google Scholar]
  21. Chaddock L, Erickson KI, Prakash RS, Kim JS, Voss MW. et al. 2010a. A neuroimaging investigation of the association between aerobic fitness, hippocampal volume, and memory performance in preadolescent children. Brain Res. 1358:172–83 [Google Scholar]
  22. Chaddock L, Erickson KI, Prakash RS, VanPatter M, Voss MW. et al. 2010b. Basal ganglia volume is associated with aerobic fitness in preadolescent children. Dev. Neurosci. 32:3249–56 [Google Scholar]
  23. Chaddock L, Hillman CH, Buck SM, Cohen NJ. 2011. Aerobic fitness and executive control of relational memory in preadolescent children. Med. Sci. Sports Exerc. 43:2344–49 [Google Scholar]
  24. Chang M, Jonsson PV, Snaedal J, Bjornsson S, Saczynski JS. et al. 2010. The effect of midlife physical activity on cognitive function among older adults: AGES-Reykjavik Study. J. Gerontol. A Biol. Sci. Med. Sci. 65:121369–74 [Google Scholar]
  25. Clark PJ, Brzezinska WJ, Thomas MW, Ryzhenko NA, Toshkov SA, Rhodes JS. 2008. Intact neurogenesis is required for benefits of exercise on spatial memory but not motor performance or contextual fear conditioning in C57BL/6J mice. Neuroscience 155:41048–58 [Google Scholar]
  26. Colcombe SJ, Erickson KI, Raz N, Webb AG, Cohen NJ. et al. 2003. Aerobic fitness reduces brain tissue loss in aging humans. J. Gerontol. A Biol. Med. Sci. 58:2176–80 [Google Scholar]
  27. Colcombe SJ, Erickson KI, Scalf PE, Kim JS, Prakash R. et al. 2006. Aerobic exercise training increases brain volume in aging humans. J. Gerontol. A Biol. Med. Sci. 61:111166–70 [Google Scholar]
  28. Colcombe SJ, Kramer AF. 2003. Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychol. Sci. 14:2125–30 [Google Scholar]
  29. Colcombe SJ, Kramer AF, Erickson KI, Scalf P. 2005. The implications of cortical recruitment and brain morphology for individual differences in inhibitory function in aging humans. Psychol. Aging 20:3363–75 [Google Scholar]
  30. Colcombe SJ, Kramer AF, Erickson KI, Scalf P, McAuley E. et al. 2004. Cardiovascular fitness, cortical plasticity, and aging. Proc. Natl. Acad. Sci. USA 101:93316–21 [Google Scholar]
  31. Cooney GM, Dwan K, Greig CA, Lawlor DA, Rimer J. et al. 2013. Exercise for depression. Cochrane Database Syst. Rev. 9:CD004366 [Google Scholar]
  32. Creer DJ, Romberg C, Saksida LM, van Praag H, Bussey TJ. 2010. Running enhances spatial pattern separation in mice. Proc. Natl. Acad. Sci. USA 107:52367–72 [Google Scholar]
  33. Cruise KE, Bucks RS, Loftus AM, Newton RU, Pegoraro R, Thomas MG. 2010. Exercise and Parkinson's: benefits for cognition and quality of life. Acta Neurol. Scand. 123:113–19 [Google Scholar]
  34. Davenport MH, Hogan DB, Eskes GA, Longman RS, Poulin MJ. 2012. Cerebrovascular reserve: the link between fitness and cognitive function?. Exerc. Sport Sci. Rev. 40:3153–58 [Google Scholar]
  35. Daviglus ML, Plassman BL, Pirzada A, Bell CC, Bowen PE. et al. 2011. Risk factors and preventive interventions for Alzheimer disease: state of the science. Arch. Neurol. 68:91185–90 [Google Scholar]
  36. Deary IJ, Whalley LJ, Batty GD, Starr JM. 2006. Physical fitness and lifetime cognitive change. Neurology 67:71195–200 [Google Scholar]
  37. Deeny SP, Winchester J, Nichol K, Roth SM, Wu JC. et al. 2012. Cardiovascular fitness is associated with altered cortical glucose metabolism during working memory in ε4 carriers. Alzheimer's Dement. 8:4352–56 [Google Scholar]
  38. Ding Q, Vaynman S, Akhavan M, Ying Z, Gómez-Pinilla F. 2006. Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function. Neuroscience 140:3823–33 [Google Scholar]
  39. Dustman RE, Emmerson RY, Ruhling RO, Shearer DE, Steinhaus LA. et al. 1990. Age and fitness effects on EEG, ERPs, visual sensitivity, and cognition. Neurobiol. Aging 11:3193–200 [Google Scholar]
  40. Eadie BD, Redila VA, Christie BR. 2005. Voluntary exercise alters the cytoarchitecture of the adult dentate gyrus by increasing cellular proliferation, dendritic complexity, and spine density. J. Comp. Neurol. 486:139–47 [Google Scholar]
  41. Erickson KI, Banducci SE, Weinstein AM, Macdonald AW. Ferrell RE. 3rd, et al. 2013. The brain-derived neurotrophic factor Val66Met polymorphism moderates an effect of physical activity on working memory performance. Psychol. Sci. 24:91770–79 [Google Scholar]
  42. Erickson KI, Miller DL, Roecklein KA. 2012. The aging hippocampus: interactions between exercise, depression, and BDNF. Neuroscientist 18:182–97 [Google Scholar]
  43. Erickson KI, Prakash RS, Voss MW, Chaddock L, Hu L. et al. 2009. Aerobic fitness is associated with hippocampal volume in elderly humans. Hippocampus 19:1030–39 [Google Scholar]
  44. Erickson KI, Raji CA, Lopez OL, Becker JT, Rosano C. et al. 2010. Physical activity predicts gray matter volume in late adulthood: the Cardiovascular Health Study. Neurology 75:161415–22 [Google Scholar]
  45. Erickson KI, Voss MW, Prakash RS, Basak C, Szabo A. et al. 2011. Exercise training increases size of hippocampus and improves memory. Proc. Natl. Acad. Sci. USA 108:73017–22 [Google Scholar]
  46. Etgen T, Sander D, Huntgeburth U, Poppert H, Forstl H, Bickel H. 2010. Physical activity and incident cognitive impairment in elderly persons: the INVADE study. Arch. Intern. Med. 170:2186–93 [Google Scholar]
  47. Etnier JL, Caselli RJ, Reiman EM, Alexander GE, Sibley BA. et al. 2007. Cognitive performance in older women relative to ApoE-ε4 genotype and aerobic fitness. Med. Sci. Sports Exerc. 39:1199–207 [Google Scholar]
  48. Etnier JL, Nowell PM, Landers DM, Sibley BA. 2006. A meta-regression to examine the relationship between aerobic fitness and cognitive performance. Brain Res. Rev. 52:1119–30 [Google Scholar]
  49. Fabel K, Fabel K, Tam B, Kaufer D, Baiker A. et al. 2003. VEGF is necessary for exercise-induced adult hippocampal neurogenesis. Eur. J. Neurosci. 18:102803–12 [Google Scholar]
  50. Farmer J, Zhao X, Van Praag H, Wodtke K, Gage FH, Christie BR. 2004. Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo. Neuroscience 124:171–79 [Google Scholar]
  51. Fedewa AL, Ahn S. 2011. The effects of physical activity and physical fitness on children's achievement and cognitive outcomes: a meta-analysis. Res. Q. Exerc. Sport 82:3521–35 [Google Scholar]
  52. Foley LS, Prapavessis H, Osuch EA, De Pace JA, Murphy BA, Podolinsky NJ. 2008. An examination of potential mechanisms for exercise as a treatment for depression: a pilot study. Ment. Health Phys. Act. 1:269–73 [Google Scholar]
  53. Forbes D, Thiessen EJ, Blake CM, Forbes SC, Forbes S. 2013. Exercise programs for people with dementia. Cochrane Database Syst. Rev. 12:CD006489 [Google Scholar]
  54. Fordyce DE, Farrar RP. 1991. Effect of physical activity on hippocampal high affinity choline uptake and muscarinic binding: a comparison between young and old F344 rats. Brain Res. 541:157–62 [Google Scholar]
  55. Freedman DS, Khan LK, Dietz WH, Srinivasan SR, Berenson GS. 2001. Relationship of childhood obesity to coronary heart disease risk factors in adulthood: the Bogalusa Heart Study. Pediatrics 108:3712–18 [Google Scholar]
  56. Gates N, Fiatarone Singh MA, Sachdev PS, Valenzuela M. 2013. The effect of exercise training on cognitive function in older adults with mild cognitive impairment: a meta-analysis of randomized controlled trials. Am. J. Geriatr. Psychiatry 21:111086–97 [Google Scholar]
  57. Gehring WJ, Goss B, Coles MGH, Meyer DE, Donchin E. 1993. A neural system for error-detection and compensation. Psychol. Sci. 4:6385–90 [Google Scholar]
  58. Gilliam PE, Spirduso WW, Martin TP, Walters TJ, Wilcox RE, Farrar RP. 1984. The effects of exercise training on [3H]-spiperone binding in rat striatum. Pharmacol. Biochem. Behav. 20:6863–67 [Google Scholar]
  59. Gómez-Pinilla F, Hillman C. 2013. The influence of exercise on cognitive abilities. Compr. Physiol. 3:1403–28 [Google Scholar]
  60. Gómez-Pinilla F, Vaynman S, Ying Z. 2008. Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition. Eur. J. Neurosci. 28:112278–87 [Google Scholar]
  61. Grady CL, Bernstein L, Siegenthaler A, Beig S. 2002. The effects of encoding task on age-related differences in the functional neuroanatomy of face memory. Psychol. Aging 17:17–23 [Google Scholar]
  62. Griffin EW, Mullally S, Foley C, Warmington SA, O'Mara SM, Kelly AM. 2011. Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males. Physiol. Behav. 104:5934–41 [Google Scholar]
  63. Gujral S, Manuck S, Ferrell RE, Flory JD, Erickson KI. 2014. The BDNF Val66Met polymorphism does not moderate the effect of self-reported physical activity on depressive symptoms in midlife. Psychiatr. Res. 218:93–97 [Google Scholar]
  64. Hamer M, Chida Y. 2009. Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence. Psychol. Med. 39:13–11 [Google Scholar]
  65. Haskell WL, Lee IM, Pate RR, Powell KE, Blair SN. et al. 2007. Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Med. Sci. Sports Exerc. 39:81423–34 [Google Scholar]
  66. Hayes SM, Hayes JP, Cadden M, Verfaellie M. 2013. A review of cardiorespiratory fitness-related neuroplasticity in the aging brain. Front. Aging Neurosci. 5:31 [Google Scholar]
  67. Head D, Bugg JM, Goate AM, Fagan AM, Mintun MA. et al. 2012. Exercise engagement as a moderator of the effects of APOE genotype on amyloid deposition. Arch. Neurol. 69:5636–43 [Google Scholar]
  68. HealthyPeople.gov 2000. Healthy People 2010 Washington, DC: US Dep. Health Hum. Serv http://www.healthypeople.gov/2010/?visit=1
  69. Hillman CH, Belopolsky AV, Snook EM, Kramer AF, McAuley E. 2004. Physical activity and executive control: implications for increased cognitive health during older adulthood. Res. Q. Exerc. Sport 75:2176–85 [Google Scholar]
  70. Hillman CH, Buck SM, Themanson JR, Pontifex MB, Castelli DM. 2009. Aerobic fitness and cognitive development: event-related brain potential and task performance indices of executive control in preadolescent children. Dev. Psychol. 45:1114–29 [Google Scholar]
  71. Hillman CH, Castelli DM, Buck SM. 2005. Aerobic fitness and neurocognitive function in healthy preadolescent children. Med. Sci. Sports Exerc. 37:111967–74 [Google Scholar]
  72. Hillman CH, Kramer AF, Belopolsky AV, Smith DP. 2006. A cross-sectional examination of age and physical activity on performance and event-related brain potentials in a task switching paradigm. Int. J. Psychophysiol. 59:130–39 [Google Scholar]
  73. Hillman CH, Weiss EP, Hagberg JM, Hatfield BD. 2002. The relationship of age and cardiovascular fitness to cognitive and motor processes. Psychophysiology 39:3303–12 [Google Scholar]
  74. Hoffman BM, Blumenthal JA, Babyak MA, Smith PJ, Rogers SD. et al. 2008. Exercise fails to improve neurocognition in depressed middle-aged and older adults. Med. Sci. Sports Exerc. 40:71344–52 [Google Scholar]
  75. Kampert JB, Blair SN, Barlow CE, Kohl HW 3rd. 1996. Physical activity, physical fitness, and all-cause and cancer mortality: a prospective study of men and women. Ann. Epidemiol. 6:5452–57 [Google Scholar]
  76. Katzmarzyk PT, Janssen I, Ardern CI. 2003. Physical inactivity, excess adiposity and premature mortality. Obes. Rev. 4:4257–90 [Google Scholar]
  77. Kemoun G, Thibaud M, Roumagne N, Carette P, Albinet C. et al. 2010. Effects of a physical training programme on cognitive function and walking efficiency in elderly persons with dementia. Dement. Geriatr. Cogn. Disord. 29:2109–14 [Google Scholar]
  78. Kleim JA, Cooper NR, VandenBerg PM. 2002. Exercise induces angiogenesis but does not alter movement representations within rat motor cortex. Brain Res. 934:11–6 [Google Scholar]
  79. Knaepen K, Goekint M, Heyman EM, Meeusen R. 2010. Neuroplasticity—exercise-induced response of peripheral brain-derived neurotrophic factor: a systematic review of experimental studies in human subjects. Sports Med. 40:9765–801 [Google Scholar]
  80. Kohman RA, Rodriguez-Zas SL, Southey BR, Kelley KW, Dantzer R, Rhodes JS. 2011. Voluntary wheel running reverses age-induced changes in hippocampal gene expression. PLOS ONE 6:8e22654 [Google Scholar]
  81. Krogh J, Saltin B, Gluud C, Nordentoft M. 2009. The DEMO trial: a randomized, parallel-group, observer-blinded clinical trial of strength versus aerobic versus relaxation training for patients with mild to moderate depression. J. Clin. Psychiatry 70:6790–800 [Google Scholar]
  82. Lautenschlager NT, Cox K. 2013. Can participation in mental and physical activity protect cognition in old age? Invited commentary. JAMA Intern. Med. 173:9805–6 [Google Scholar]
  83. Lautenschlager NT, Cox K, Cyarto EV. 2012. The influence of exercise on brain aging and dementia. Biochim. Biophys. Acta 1822:3474–81 [Google Scholar]
  84. Lautenschlager NT, Cox KL, Flicker L, Foster JK, van Bockxmeer FM. et al. 2008. Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. JAMA 300:91027–37 [Google Scholar]
  85. Lee IM, Shiroma EJ, Lobelo F, Puska P, Blair SN, Katzmarzyk PT. 2012. Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet 380:9838219–29 [Google Scholar]
  86. Lees C, Hopkins J. 2013. Effect of aerobic exercise on cognition, academic achievement, and psychosocial function in children: a systematic review of randomized control trials. Prev. Chronic Dis. 10:130010 [Google Scholar]
  87. Lindamer LA, McKibbin C, Norman GJ, Jordan L, Harrison K. et al. 2008. Assessment of physical activity in middle-aged and older adults with schizophrenia. Schizophr. Res. 104:1–3294–301 [Google Scholar]
  88. Lindsay J, Laurin D, Verreault R, Hebert R, Helliwell B. et al. 2002. Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging. Am. J. Epidemiol. 156:5445–53 [Google Scholar]
  89. Liu-Ambrose T, Nagamatsu LS, Graf P, Beattie BL, Ashe MC, Handy TC. 2010. Resistance training and executive functions: a 12-month randomized controlled trial. Arch. Intern. Med. 170:2170–78 [Google Scholar]
  90. Liu-Ambrose T, Nagamatsu LS, Voss MW, Khan KM, Handy TC. 2012. Resistance training and functional plasticity of the aging brain: a 12-month randomized controlled trial. Neurobiol. Aging 33:81690–98 [Google Scholar]
  91. MacRae PG, Spirduso WW, Walters TJ, Farrar RP, Wilcox RE. 1987. Endurance training effects on striatal D2 dopamine receptor binding and striatal dopamine metabolites in presenescent older rats. Psychopharmacology 92:2236–40 [Google Scholar]
  92. Marques-Aleixo I, Oliveira PJ, Moreira PI, Magalhães J, Ascensão A. 2012. Physical exercise as a possible strategy for brain protection: evidence from mitochondrial-mediated mechanisms. Progress Neurobiol. 99:2149–62 [Google Scholar]
  93. Mata J, Thompson RJ, Gotlib IH. 2010. BDNF genotype moderates the relation between physical activity and depressive symptoms. Health Psychol. 29:2130–33 [Google Scholar]
  94. Middleton LE, Barnes DE, Lui LY, Yaffe K. 2010. Physical activity over the life course and its association with cognitive performance and impairment in old age. J. Am. Geriatr. Soc. 58:71322–26 [Google Scholar]
  95. Miller EK, Cohen JD. 2001. An integrative theory of prefrontal cortex function. Annu. Rev. Neurosci. 24:167–202 [Google Scholar]
  96. Mittal VA, Gupta T, Orr JM, Pelletier-Baldelli A, Dean DJ. et al. 2013. Physical activity level and medial temporal health in youth at ultra high-risk for psychosis. J. Abnorm. Psychol. 122:41101–10 [Google Scholar]
  97. Murray DK, Sacheli MA, Eng JJ, Stoessl AJ. 2014. The effects of exercise on cognition in Parkinson's disease: a systematic review. Transl. Neurodegener. 3:15 [Google Scholar]
  98. Nagai M, Kuriyama S, Kakizaki M, Ohmori-Matsuda K, Sone T. et al. 2011. Impact of walking on life expectancy and lifetime medical expenditure: the Ohsaki Cohort Study. BMJ Open 1:2e000240 [Google Scholar]
  99. Nagamatsu LS, Chan A, Davis JC, Beattie BL, Graf P. et al. 2013. Physical activity improves verbal and spatial memory in older adults with probable mild cognitive impairment: a 6-month randomized controlled trial. J. Aging Res. 2013:121–107 [Google Scholar]
  100. Neeper SA, Gómez-Pinilla F, Choi J, Cotman C. 1995. Exercise and brain neurotrophins. Nature 373:6510109 [Google Scholar]
  101. Neeper SA, Gómez-Pinilla F, Choi J, Cotman CW. 1996. Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain Res. 726:1–249–56 [Google Scholar]
  102. Nelson ME, Rejeski JW, Blair SN, Duncan PW, Judge JO. et al. 2007. Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association. Med. Sci. Sports Exerc. 39:81435–45 [Google Scholar]
  103. Ogden CL, Carroll MD, Kit BK, Flegal KM. 2012. Prevalence of obesity and trends in body mass index among US children and adolescents, 1999–2010. JAMA 307:5483–90 [Google Scholar]
  104. Pajonk F-G, Wobrock T, Gruber O, Scherk H, Berner D. et al. 2010. Hippocampal plasticity in response to exercise in schizophrenia. Arch. Gen. Psychiatry 67:2133–43 [Google Scholar]
  105. Pang TY, Stam NC, Nithianantharajah J, Howard ML, Hannan AJ. 2006. Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington's disease transgenic mice. Neuroscience 141:2569–84 [Google Scholar]
  106. Park DC, Lodi-Smith J, Drew L, Haber S, Hebrank A. et al. 2014. The impact of sustained engagement on cognitive function in older adults: the Synapse project. Psychol. Sci. 25:1103–12 [Google Scholar]
  107. Pereira AC, Huddleston DE, Brickman AM, Sosunov AA, Hen R. et al. 2007. An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc. Natl. Acad. Sci. USA 104:135638–43 [Google Scholar]
  108. Phys. Act. Guidel. Advis. Comm 2008. Physical Activity Guidelines Committee Report, 2008. Washington, DC: US Dep. Health Hum. Serv.
  109. Phys. Act. Guidel. Am. Midcourse Rep. Subcomm. Pres. Counc. Fit. Sports Nutr 2012. Physical Activity Guidelines for Americans Midcourse Report: Strategies to Increase Physical Activity Among Youth. Washington, DC: US Dep. Health Hum. Serv.
  110. Pickett K, Yardley L, Kendrick T. 2012. Physical activity and depression: a multiple mediation analysis. Ment. Health Phys. Act. 5:2125–34 [Google Scholar]
  111. Pierpaoli C, Jezzard P, Basser PJ, Barnett A, Di Chiro G. 1996. Diffusion tensor MR imaging of the human brain. Radiology 201:3637–48 [Google Scholar]
  112. Pietrelli A, Lopez-Costa J, Goñi R, Brusco A, Basso N. 2012. Aerobic exercise prevents age-dependent cognitive decline and reduces anxiety-related behaviors in middle-aged and old rats. Neuroscience 202:252–66 [Google Scholar]
  113. Pontifex MB, Hillman CH, Polich J. 2009. Age, physical fitness, and attention: P3a and P3b. Psychophysiology 46:2379–87 [Google Scholar]
  114. Pontifex MB, Raine L, Johnson C, Chaddock L, Voss M. et al. 2011. Cardiorespiratory fitness and the flexible modulation of cognitive control in preadolescent children. J. Cogn. Neurosci. 23:61332–45 [Google Scholar]
  115. Pontifex MB, Saliba BJ, Raine LB, Picchietti DL, Hillman CH. 2013. Exercise improves behavioral, neurocognitive, and scholastic performance in children with attention-deficit/hyperactivity disorder. J. Pediatr. 162:3543–51 [Google Scholar]
  116. Potter MC, Yuan C, Ottenritter C, Mughal M, van Praag H. 2010. Exercise is not beneficial and may accelerate symptom onset in a mouse model of Huntington's disease. PLOS Curr. 2:RRN1201 [Google Scholar]
  117. Prakash RS, Erickson KI, Colcombe SJ, Kim JS, Voss MW, Kramer AF. 2009. Age-related differences in the involvement of the prefrontal cortex in attentional control. Brain Cogn. 71:3328–35 [Google Scholar]
  118. Prakash RS, Erickson KI, Snook EM, Colcombe SJ, Motl RW, Kramer AF. 2008. Cortical recruitment during selective attention in multiple sclerosis: an fMRI investigation of individual differences. Neuropsychologia 46:122888–95 [Google Scholar]
  119. Prakash RS, Snook EM, Erickson KI, Colcombe SJ, Voss MW. et al. 2007. Cardiorespiratory fitness: a predictor of cortical plasticity in multiple sclerosis. NeuroImage 34:31238–44 [Google Scholar]
  120. Prakash RS, Snook EM, Motl RW, Kramer AF. 2010. Aerobic fitness is associated with gray matter volume and white matter integrity in multiple sclerosis. Brain Res. 1341:41–51 [Google Scholar]
  121. Prakash RS, Voss MW, Erickson KI, Lewis JM, Chaddock L. et al. 2011. Cardiorespiratory fitness and attentional control in the aging brain. Front. Hum. Neurosci. 4:229 [Google Scholar]
  122. Rasmussen P, Brassard P, Adser H, Pedersen MV, Leick L. et al. 2009. Evidence for a release of brain-derived neurotrophic factor from the brain during exercise. Exp. Physiol. 94:101062–69 [Google Scholar]
  123. Ratcliff R. 1978. A theory of memory retrieval. Psychol. Rev. 85:259–108 [Google Scholar]
  124. Ratcliff R, Love J, Thompson CA, Opfer JE. 2012. Children are not like older adults: a diffusion model analysis of developmental changes in speeded responses. Child Dev. 83:1367–81 [Google Scholar]
  125. Ratcliff R, McKoon G. 2008. The diffusion decision model: theory and data for two-choice decision tasks. Neural Comput. 20:4873–922 [Google Scholar]
  126. Ratcliff R, Thapar A, Gomez P, McKoon G. 2004. A diffusion model analysis of the effects of aging in the lexical-decision task. Psychol. Aging 19:2278–89 [Google Scholar]
  127. Ratcliff R, Thapar A, McKoon G. 2001. The effects of aging on reaction time in a signal detection task. Psychol. Aging 16:2323–41 [Google Scholar]
  128. Raz N, Lindenberger U, Rodrigue KM, Kennedy KM, Head D. et al. 2005. Regional brain changes in aging healthy adults: general trends, individual differences and modifiers. Cereb. Cortex 15:111676–89 [Google Scholar]
  129. Real CC, Ferreira AFB, Chaves-Kirsten GP, Torrão AS, Pires RS, Britto LRG. 2013. BDNF receptor blockade hinders the beneficial effects of exercise in a rat model of Parkinson's disease. Neuroscience 237:C118–29 [Google Scholar]
  130. Reuter-Lorenz PA, Mikels J. 2006. The aging brain: implications of enduring plasticity for behavioral and cultural change. Lifespan Development and the Brain: The Perspective of Biocultural Co-Constructivism P Baltes, PA Reuter-Lorenz, F Roesler 255–76 Cambridge, UK: Cambridge Univ. Press [Google Scholar]
  131. Richards M, Hardy R, Wadsworth ME. 2003. Does active leisure protect cognition? Evidence from a national birth cohort. Soc. Sci. Med. 56:4785–92 [Google Scholar]
  132. Rosano C, Venkatraman VK, Guralnik J, Newman AB, Glynn NW. et al. 2010. Psychomotor speed and functional brain MRI 2 years after completing a physical activity treatment. J. Gerontol. A Biol. Sci. Med. Sci. 65:6639–47 [Google Scholar]
  133. Rosenzweig M. 1966. Environmental complexity, cerebral change, and behavior. Am. Psychol. 21:4321–32 [Google Scholar]
  134. Rovio S, Kåreholt I, Helkala E-L, Viitanen M, Winblad B. et al. 2005. Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease. Lancet Neurol. 4:11705–11 [Google Scholar]
  135. Rovio S, Spulber G, Nieminen LJ, Niskanen E, Winblad B. et al. 2010. The effect of midlife physical activity on structural brain changes in the elderly. Neurobiol. Aging 31:111927–36 [Google Scholar]
  136. Rugg MD, Coles MG. 1995. Electrophysiology of Mind: Event-Related Brain Potentials and Cognition London: Oxford Univ. Press
  137. Ruscheweyh R, Willemer C, Kruger K, Duning T, Warnecke T. et al. 2011. Physical activity and memory functions: an interventional study. Neurobiol. Aging 32:71304–19 [Google Scholar]
  138. Sabia S, Nabi H, Kivimaki M, Shipley MJ, Marmot MG, Singh-Manoux A. 2009. Health behaviors from early to late midlife as predictors of cognitive function: the Whitehall II study. Am. J. Epidemiol. 170:4428–37 [Google Scholar]
  139. Samitz G, Egger M, Zwahlen M. 2011. Domains of physical activity and all-cause mortality: systematic review and dose-response meta-analysis of cohort studies. Int. J. Epidemiol. 40:51382–400 [Google Scholar]
  140. Schuit AJ, Feskens EJ, Launer LJ, Kromhout D. 2001. Physical activity and cognitive decline, the role of the apolipoprotein e4 allele. Med. Sci. Sports Exerc. 33:5772–77 [Google Scholar]
  141. Scisco JL, Leynes PA, Kang J. 2008. Cardiovascular fitness and executive control during task-switching: an ERP study. Int. J. Psychophysiol. 69:152–60 [Google Scholar]
  142. Shohamy D, Turk-Browne NB. 2013. Mechanisms for widespread hippocampal involvement in cognition. J. Exp. Psychol.: Gen. 142:41159–70 [Google Scholar]
  143. Sibley BA, Etnier JL. 2003. The relationship between physical activity and cognition in children: a meta-analysis. Pediatr. Exerc. Sci. 15:3243–56 [Google Scholar]
  144. Singh-Manoux A, Ferrie JE, Lynch JW, Marmot M. 2005. The role of cognitive ability (intelligence) in explaining the association between socioeconomic position and health: evidence from the Whitehall II prospective cohort study. Am. J. Epidemiol. 161:9831–39 [Google Scholar]
  145. Sisson SB, Church TS, Martin CK, Tudor-Locke C, Smith SR. et al. 2009. Profiles of sedentary behavior in children and adolescents: the US National Health and Nutrition Examination Survey, 2001–2006. Int. J. Pediatr. Obes. 4:4353–59 [Google Scholar]
  146. Smith AL, Hoza B, Linnea K, McQuade JD, Tomb M. et al. 2012. Pilot physical activity intervention reduces severity of ADHD symptoms in young children. J. Atten. Disord. 17:170–82 [Google Scholar]
  147. Smith JC, Nielson KA, Woodard JL, Seidenberg M, Durgerian S. et al. 2011. Interactive effects of physical activity and APOE-ϵ4 on BOLD semantic memory activation in healthy elders. NeuroImage 54:1635–44 [Google Scholar]
  148. Smith PJ, Blumenthal JA, Hoffman BM, Cooper H, Strauman TA. et al. 2010. Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials. Psychosom. Med. 72:3239–52 [Google Scholar]
  149. Sofi F, Valecchi D, Bacci D, Abbate R, Gensini GF. et al. 2011. Physical activity and risk of cognitive decline: a meta-analysis of prospective studies. J. Intern. Med. 269:1107–17 [Google Scholar]
  150. Stavrakakis N, Roest AM, Verhulst F, Ormel J, de Jonge P, Oldehinkel AJ. 2013. Physical activity and onset of depression in adolescents: a prospective study in the general population cohort TRAILS. J. Psychiatr. Res. 47:101304–8 [Google Scholar]
  151. Steiner JL, Murphy EA, McClellan JL, Carmichael MD, Davis JM. 2011. Exercise training increases mitochondrial biogenesis in the brain. J. Appl. Physiol. 111:41066–71 [Google Scholar]
  152. Stewart R, Prince M, Mann A. 2003. Age, vascular risk, and cognitive decline in an older, British, African-Caribbean population. J. Am. Geriatr. Soc. 51:111547–53 [Google Scholar]
  153. Stine-Morrow EA, Parisi JM, Morrow DG, Park DC. 2008. The effects of an engaged lifestyle on cognitive vitality: a field experiment. Psychol. Aging 23:4778–86 [Google Scholar]
  154. Stranahan AM, Khalil D, Gould E. 2007. Running induces widespread structural alterations in the hippocampus and entorhinal cortex. Hippocampus 17:111017–22 [Google Scholar]
  155. Stroop JR. 1935. Studies of interference in serial verbal reactions. J. Exp. Psychol. 18:6643–62 [Google Scholar]
  156. Stroth S, Hille K, Spitzer M, Reinhardt R. 2009. Aerobic endurance exercise benefits memory and affect in young adults. Neuropsychol. Rehabil. 19:2223–43 [Google Scholar]
  157. Stroth S, Reinhardt RK, Thone J, Hille K, Schneider M. et al. 2010. Impact of aerobic exercise training on cognitive functions and affect associated to the COMT polymorphism in young adults. Neurobiol. Learn. Mem. 94:3364–72 [Google Scholar]
  158. Sturman MT, Morris MC, Mendes de Leon CF, Bienias JL, Wilson RS, Evans DA. 2005. Physical activity, cognitive activity, and cognitive decline in a biracial community population. Arch. Neurol. 62:111750–54 [Google Scholar]
  159. Tabbarah M, Crimmins EM, Seeman TE. 2002. The relationship between cognitive and physical performance: MacArthur studies of successful aging. J. Gerontol. A Biol. Sci. Med. Sci. 57:4M228–35 [Google Scholar]
  160. Tamber-Rosenau BJ, Esterman M, Chiu YC, Yantis S. 2011. Cortical mechanisms of cognitive control for shifting attention in vision and working memory. J. Cogn. Neurosci. 23:102905–19 [Google Scholar]
  161. Tanaka K, de Quadros AC, Santos RF, Stella F, Gobbi LTB, Gobbi S. 2009. Benefits of physical exercise on executive functions in older people with Parkinson's disease. Brain Cogn. 69:2435–41 [Google Scholar]
  162. Themanson JR, Hillman CH. 2006. Cardiorespiratory fitness and acute aerobic exercise effects on neuroelectric and behavioral measures of action monitoring. Neuroscience 141:2757–67 [Google Scholar]
  163. Themanson JR, Pontifex MB, Hillman CH. 2008. Fitness and action monitoring: evidence for improved cognitive flexibility in young adults. Neuroscience 157:2319–28 [Google Scholar]
  164. Thomas AG, Dennis A, Bandettini PA, Johansen-Berg H. 2012. The effects of aerobic activity on brain structure. Front. Psychol. 3:86 [Google Scholar]
  165. Trejo JL, Carro E, Torres-Aleman I. 2001. Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus. J. Neurosci. 21:51628–34 [Google Scholar]
  166. van Praag H, Christie BR, Sejnowski TJ, Gage FH. 1999b. Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc. Natl. Acad. Sci. USA 96:2313427–31 [Google Scholar]
  167. van Praag H, Kempermann G, Gage FH. 1999a. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat. Neurosci. 2:3266–70 [Google Scholar]
  168. van Praag H, Shubert T, Zhao C, Gage FH. 2005. Exercise enhances learning and hippocampal neurogenesis in aged mice. J. Neurosci. 25:388680–85 [Google Scholar]
  169. van Uffelen JGZ, Chinapaw MJM, van Mechelen W, Hopman-Rock M. 2008. Walking or vitamin B for cognition in older adults with mild cognitive impairment? A randomised controlled trial. Br. J. Sports Med. 42:5344–51 [Google Scholar]
  170. Vancampfort D, Probst M, De Hert M, Soundy A, Stubbs B. et al. 2014. Neurobiological effects of physical exercise in schizophrenia: a systematic review. Disabil. Rehabil. 36211749–54
  171. Vancampfort D, Probst M, Scheewe T, Maurissen K, Sweers K. et al. 2011. Lack of physical activity during leisure time contributes to an impaired health related quality of life in patients with schizophrenia. Schizophr. Res. 129:2–3122–27 [Google Scholar]
  172. Vaynman S, Ying Z, Gómez-Pinilla F. 2004. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur. J. Neurosci. 20:102580–90 [Google Scholar]
  173. Verghese J, LeValley A, Derby C, Kuslansky G, Katz M. et al. 2006. Leisure activities and the risk of amnestic mild cognitive impairment in the elderly. Neurology 66:6821–27 [Google Scholar]
  174. Verret L, Mann EO, Hang GB, Barth AMI, Cobos I. et al. 2012. Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model. Cell 149:3708–21 [Google Scholar]
  175. Voss MW, Erickson KI, Prakash RS, Chaddock L, Kim JS. et al. 2013a. Neurobiological markers of exercise-related brain plasticity in older adults. Brain Behav. Immun. 28:C90–99 [Google Scholar]
  176. Voss MW, Heo S, Prakash RS, Erickson KI, Alves H. et al. 2013. The influence of aerobic fitness on cerebral white matter integrity and cognitive function in older adults: results of a one-year exercise intervention. Hum. Brain Mapp. 34:112972–85 [Google Scholar]
  177. Voss MW, Prakash RS, Erickson KI, Basak C, Chaddock L. et al. 2010. Plasticity of brain networks in a randomized intervention trial of exercise training in older adults. Front. Aging Neurosci. 2:1–17 [Google Scholar]
  178. Voss MW, Vivar C, Kramer AF, van Praag H. 2013b. Bridging animal and human models of exercise-induced brain plasticity. Trends Cogn. Sci. 17:10525–44 [Google Scholar]
  179. Weintraub S, Dikmen SS, Heaton RK, Tulsky DS, Zelazo PD. et al. 2013. Cognition assessment using the NIH Toolbox. Neurology 80:11 Suppl. 3S54–64 [Google Scholar]
  180. Woodard JL, Sugarman MA, Nielson KA, Smith JC, Seidenberg M. et al. 2012. Lifestyle and genetic contributions to cognitive decline and hippocampal structure and function in healthy aging. Curr. Alzheimer Res. 9:4436–46 [Google Scholar]
  181. Yaffe K, Fiocco AJ, Lindquist K, Vittinghoff E, Simonsick EM. et al. 2009. Predictors of maintaining cognitive function in older adults: the Health ABC study. Neurology 72:232029–35 [Google Scholar]
  182. Yágüez L, Shaw KN, Morris R, Matthews D. 2010. The effects on cognitive functions of a movement-based intervention in patients with Alzheimer's type dementia: a pilot study. Int. J. Geriatr. Psychiatry 26:2173–81 [Google Scholar]
  183. Ziegler G, Dahnke R, Jancke L, Yotter RA, May A, Gaser C. 2012. Brain structural trajectories over the adult lifespan. Hum. Brain Mapp. 33:102377–89 [Google Scholar]
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