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Annual Review of Biophysics

Volume 39, 2010

Adventures in Physical Chemistry

Abstract

My research has included chemical physics, electron and NMR spectroscopy, membrane biophysics, and immunology. This research was curiosity driven as well as problem and technique oriented. A theoretical equation was developed for relating nuclear hyperfine splittings to electron spin distributions in free radicals. Another equation was developed to relate NMR spectra to chemical reaction rates. Early evidence for the liquid-like properties of cell membranes was obtained through the use of paramagnetic probes (spin labels). Spin labels were used in measurements of lateral as well as transverse diffusion of phospholipids in bilayer membranes. Liquid-liquid phase separations were discovered in monolayer membranes containing phospholipids and cholesterol. In the area of immunology, it was shown that antigenic peptides bind to reconstituted class II MHC molecules in membranes and trigger specific T-helper cells.

Keyword(s): Autobiography, immune recognition, magnetic resonance, membranes, molecular electronic structure
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2010-06-09
2024-05-08
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Adventures in Physical Chemistry
Annual Review of Biophysics 39, 1 (2010); https://doi.org/10.1146/annurev.biophys.093008.131315
/content/journals/10.1146/annurev.biophys.093008.131315
/content/journals/10.1146/annurev.biophys.093008.131315
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