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Annual Review of Genetics

Volume 40, 2006

Review Article

Cellular Responses to DNA Damage: One Signal, Multiple Choices

Tin Tin Su¹
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Affiliations: Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309-0347; email: [email protected]
Vol. 40:187-208 (Volume publication date December 2006) https://doi.org/10.1146/annurev.genet.40.110405.090428
First published as a Review in Advance on June 28, 2006
© Annual Reviews

Abstract

Abstract

DNA double-strand breaks (DSBs) produce a number of cellular responses, some mutually exclusive. Depending on where on the chromosome it occurs, a DSB may become preserved inside a telomere or eliminated by repair. A cell may arrest division via checkpoint activation to fix DSBs or commit suicide by apoptosis. What determines the outcome: to bury, fix, or succumb to DNA DSBs? With this question in mind, we review recent data on cellular responses to DSBs.

Keyword(s): apoptosis, checkpoints, DNA damage, DNA repair

[Erratum, Closure]

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Cellular Responses to DNA Damage: One Signal, Multiple Choices

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2006-12-01

2024-04-25

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Cellular Responses to DNA Damage: One Signal, Multiple Choices

Annual Review of Genetics 40, 187 (2006); https://doi.org/10.1146/annurev.genet.40.110405.090428

/content/journals/10.1146/annurev.genet.40.110405.090428

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Article Type: Review Article

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