Genomics and Human Genetics

Volume 2, 2001

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A NEW APPROACH TO DECODING LIFE: Systems Biology

Annual Review of Genomics and Human Genetics

Vol. 2: 343-372 (Volume publication date September 2001)

DOI: 10.1146/annurev.genom.2.1.343

Trey Ideker^1,2, Timothy Galitski¹, and Leroy Hood^1,2,3,4,5

Institute for Systems Biology¹, Seattle, Washington 98105; e-mail: tideker@systemsbiology.org tgalitski@systemsbiology.org

Departments of Molecular Biotechnology², University of Washington, Seattle, Washington 98195; e-mail: lhood@systemsbiology.org

Departments of Immunology³, University of Washington, Seattle, Washington 98195;

Departments of Bioengineering⁴, University of Washington, Seattle, Washington 98195;

Departments of Computer Science and Engineering⁵, University of Washington, Seattle, Washington 98195;

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ABSTRACT

▪ Abstract Systems biology studies biological systems by systematically perturbing them (biologically, genetically, or chemically); monitoring the gene, protein, and informational pathway responses; integrating these data; and ultimately, formulating mathematical models that describe the structure of the system and its response to individual perturbations. The emergence of systems biology is described, as are several examples of specific systems approaches.

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