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Abstract

Abstract

The pathogenic roles of B cells in autoimmune diseases occur through several mechanistic pathways that include autoantibodies, immune complexes, dendritic and T cell activation, cytokine synthesis, chemokine-mediated functions, and ectopic neolymphogenesis. Each of these pathways participate to different degrees in autoimmune diseases. The use of B cell–targeted and B cell subset–targeted therapies in humans is illuminating the mechanisms at work in a variety of human autoimmune diseases. In this review, we highlight some of these recent findings that provide insights into both murine models of autoimmunity and human autoimmune diseases.

Keyword(s): BAFF/BLySBR3CD20Rituxan
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/content/journals/10.1146/annurev.immunol.24.021605.090517
2006-04-23
2024-03-29
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/content/journals/10.1146/annurev.immunol.24.021605.090517
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  • Article Type: Review Article
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