1932

Abstract

The Mediterranean dietary pattern has been linked with reduced cardiovascular disease incidence and mortality. Components of the Mediterranean diet associated with better cardiovascular health include low consumption of meat and meat products, moderate consumption of ethanol (mostly from wine), and high consumption of vegetables, fruits, nuts, legumes, fish, and olive oil. Increasing evidence indicates that the synergy among these components results in beneficial changes in intermediate pathways of cardiometabolic risk, such as lipids, insulin sensitivity, oxidative stress, inflammation, and vasoreactivity. As a result, consumption of a Mediterranean dietary pattern favorably affects numerous cardiovascular disease risk factors, such as dyslipidemia, hypertension, metabolic syndrome, and diabetes. Moreover, strong evidence links this dietary pattern with reduced cardiovascular disease incidence, reoccurrence, and mortality. This review evaluates the current evidence behind the cardioprotective effects of a Mediterranean dietary pattern.

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Mediterranean Dietary Patterns and Cardiovascular Health
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2015-07-17
2024-03-29
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Literature Cited

  1. Anderson RA, Evans ML, Ellis GR, Graham J, Morris K. 1.  et al. 2001. The relationships between post-prandial lipaemia, endothelial function and oxidative stress in healthy individuals and patients with type 2 diabetes. Atherosclerosis 154:475–83 [Google Scholar]
  2. Aparicio R, Harwood J. 2.  2013. Handbook of Olive Oil New York: Springer
  3. Avolio AP, Chen SG, Wang RP, Zhang CL, Li MF, O'Rourke MF. 3.  1983. Effects of aging on changing arterial compliance and left ventricular load in a northern Chinese urban community. Circulation 68:50–58 [Google Scholar]
  4. Babio N, Bullo M, Basora J, Martínez-González M, Fernández-Ballart J. 4.  et al. 2009. Adherence to the Mediterranean diet and risk of metabolic syndrome and its components. Nutr. Metab. Cardiovasc. 19:563–70 [Google Scholar]
  5. Babio N, Sorlí M, Bulló M, Basora J, Ibarrola-Jurado N. 5.  et al. 2012. Association between red meat consumption and metabolic syndrome in a Mediterranean population at high cardiovascular risk: cross-sectional and 1-year follow-up assessment. Nutr. Metab. Cardiovasc. 22:200–7 [Google Scholar]
  6. Barnard ND, Cohen J, Jenkins DJ, Turner-McGrievy G, Gloede L. 6.  et al. 2006. A low-fat vegan diet improves glycemic control and cardiovascular risk factors in a randomized clinical trial in individuals with type 2 diabetes. Diabetes Care 29:1777–83 [Google Scholar]
  7. Bertoia ML, Triche EW, Michaud DS, Baylin A, Hogan JW. 7.  et al. 2014. Mediterranean and dietary approaches to stop hypertension dietary patterns and risk of sudden cardiac death in postmenopausal women. Am. J. Clin. Nutr. 99:344–51 [Google Scholar]
  8. Blomhoff R, Carlsen MH, Andersen LF, Jacobs DR. 8.  2006. Health benefits of nuts: potential role of antioxidants. Br. J. Nutr. 96:S52–60 [Google Scholar]
  9. Camargo CA Jr, Hennekens CH, Gaziano J, Glynn RJ, Manson JE, Stampfer MJ. 9.  1997. Prospective study of moderate alcohol consumption and mortality in US male physicians. Arch. Intern. Med. 157:79–85 [Google Scholar]
  10. Carlsen MH, Halvorsen BL, Holte K, Bohn SK, Dragland S. 10.  et al. 2010. The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide. Nutr. J. 9:1–11 [Google Scholar]
  11. Ceriello A, Bortolotti N, Motz E, Pieri C, Marra M. 11.  et al. 1999. Meal-induced oxidative stress and low-density lipoprotein oxidation in diabetes: the possible role of hyperglycemia. Metabolism 48:1503–8 [Google Scholar]
  12. Craig WJ. 12.  1999. Health-promoting properties of common herbs. Am. J. Clin. Nutr. 70:491–99 [Google Scholar]
  13. Cuevas AM, Germain AM. 13.  2004. Diet and endothelial function. Biol. Res. 37:225–30 [Google Scholar]
  14. Dai J, Jones DP, Goldberg J, Ziegler TR, Bostick RM. 14.  et al. 2008. Association between adherence to the Mediterranean diet and oxidative stress. Am. J. Clin. Nutr. 88:1364–70 [Google Scholar]
  15. Daviglus ML, Stamler J, Orencia AJ, Dyer AR, Liu K. 15.  et al. 1997. Fish consumption and the 30-year risk of fatal myocardial infarction. N. Engl. J. Med. 336:1046–53 [Google Scholar]
  16. de Lorgeril M, Salen P, Martin JL, Monjaud I, Delaye J, Mamelle N. 16.  1999. Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. Circulation 99:779–85 [Google Scholar]
  17. Dehghan M, Mente A, Teo KK, Gao P, Sleight P. 17.  et al. 2012. Relationship between healthy diet and risk of cardiovascular disease among patients on drug therapies for secondary prevention: a prospective cohort study of 31,546 high-risk individuals from 40 countries. Circulation 126:2705–12 [Google Scholar]
  18. Desjardins F, Balligand JL. 18.  2006. Nitric oxide-dependent endothelial function and cardiovascular disease. Acta Clin. Belg. 61:326–34 [Google Scholar]
  19. Després J-P, Lemieux I. 19.  2006. Abdominal obesity and metabolic syndrome. Nature 444:881–87 [Google Scholar]
  20. Dietschy JM. 20.  1998. Dietary fatty acids and the regulation of plasma low density lipoprotein cholesterol concentrations. J. Nutr. 128:444–48S [Google Scholar]
  21. Dimmitt SB, Rakic V, Puddey IB, Baker R, Oostryck R. 21.  et al. 1998. The effects of alcohol on coagulation and fibrinolytic factors: a controlled trial. Blood Coagul. Fibrinolysis 9:39–45 [Google Scholar]
  22. Domenech M, Roman P, Lapetra J, Garcia de la Corte FJ, Sala-Vila A. 22.  et al. 2014. Mediterranean diet reduces 24-hour ambulatory blood pressure, blood glucose, and lipids: one-year randomized, clinical trial. Hypertension 64:69–76 [Google Scholar]
  23. Domingo JL, Bocio A, Falcó G, Llobet JM. 23.  2007. Benefits and risks of fish consumption: part I. A quantitative analysis of the intake of omega-3 fatty acids and chemical contaminants. Toxicology 230:219–26 [Google Scholar]
  24. Eckel RH, Jakicic JM, Ard JD, Hubbard VS, de Jesus JM. 24.  et al. 2013. 2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk. A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 63:2960–84 [Google Scholar]
  25. Ehnholm C, Huttunen JK, Pietinen P, Leino U, Mutanen M. 25.  et al. 1984. Effect of a diet low in saturated fatty acids on plasma lipids, lipoproteins, and HDL subfractions. Arteriosclerosis 4:265–69 [Google Scholar]
  26. Esposito K, Ciotola M, Giugliano D. 26.  2006. Mediterranean diet, endothelial function and vascular inflammatory markers. Public Health Nutr. 9:1073–76 [Google Scholar]
  27. Esposito K, Marfella R, Ciotola M, Di Palo C, Giugliano F. 27.  et al. 2004. Effect of a Mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. JAMA 292:1440–46 [Google Scholar]
  28. Estruch R, Martínez-González MA, Corella D, Salas-Salvadó J, Ruiz-Gutiérrez V. 28.  et al. 2006. Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial. Ann. Intern. Med. 145:1–11 [Google Scholar]
  29. Estruch R, Ros E, Salas-Salvado J, Covas MI, Corella D. 29.  et al. 2013. Primary prevention of cardiovascular disease with a Mediterranean diet. N. Engl. J. Med. 368:1279–90 [Google Scholar]
  30. Fagard RH. 30.  2001. Exercise characteristics and the blood pressure response to dynamic physical training. Med. Sci. Sports Exerc. 33:S484–92; discussion S493–94 [Google Scholar]
  31. Fito M, Guxens M, Corella D, Saez G, Estruch R. 31.  et al. 2007. Effect of a traditional Mediterranean diet on lipoprotein oxidation: a randomized controlled trial. Arch. Intern. Med. 167:1195–203 [Google Scholar]
  32. Fuentes F, López-Miranda J, Sánchez E, Sánchez F, Paez J. 32.  et al. 2001. Mediterranean and low-fat diets improve endothelial function in hypercholesterolemic men. Ann. Intern. Med. 134:1115–19 [Google Scholar]
  33. Fung TT, Rexrode KM, Mantzoros CS, Manson JE, Willett WC, Hu FB. 33.  2009. Mediterranean diet and incidence of and mortality from coronary heart disease and stroke in women. Circulation 119:1093–100 [Google Scholar]
  34. Gardener H, Scarmeas N, Gu Y, Boden-Albala B, Elkind MSV. 34.  et al. 2012. Mediterranean diet and white matter hyperintensity volume in the Northern Manhattan study. Arch. Neurol. 69:251–56 [Google Scholar]
  35. Gardener H, Wright CB, Cabral D, Scarmeas N, Gu Y. 35.  et al. 2014. Mediterranean diet and carotid atherosclerosis in the Northern Manhattan Study. Atherosclerosis 234:303–10 [Google Scholar]
  36. Gaziano JM, Buring JE, Breslow JL, Goldhaber SZ, Rosner B. 36.  et al. 1993. Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction. N. Engl. J. Med. 329:1829–34 [Google Scholar]
  37. Goldman L, Cook EF. 37.  1984. The decline in ischemic heart disease mortality rates: an analysis of the comparative effects of medical interventions and changes in lifestyle. Ann. Intern. Med. 101:825–36 [Google Scholar]
  38. Grundy SM, Brewer HB, Cleeman JI, Smith SC, Lenfant C. 38.  et al. 2004. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 109433–38
  39. Halcox JP, Schenke WH, Zalos G, Mincemoyer R, Prasad A. 39.  et al. 2002. Prognostic value of coronary vascular endothelial dysfunction. Circulation 106:653–58 [Google Scholar]
  40. Heitzer T, Schlinzig T, Krohn K, Meinertz T, Münzel T. 40.  2001. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 104:2673–78 [Google Scholar]
  41. Hossain P, Kawar B, El Nahas M. 41.  2007. Obesity and diabetes in the developing world—a growing challenge. N. Engl. J. Med. 356:213–15 [Google Scholar]
  42. Hu FB, Bronner L, Willett WC, Stampfer MJ, Rexrode KM. 42.  et al. 2002. Fish and omega-3 fatty acid intake and risk of coronary heart disease in women. JAMA 287:1815–21 [Google Scholar]
  43. Hu FB, Stampfer MJ, Rimm E, Ascherio A, Rosner BA. 43.  et al. 1999. Dietary fat and coronary heart disease: a comparison of approaches for adjusting for total energy intake and modeling repeated dietary measurements. Am. J. Epidemiol. 149:531–40 [Google Scholar]
  44. Huynh NN, Chin-Dusting J. 44.  2006. Amino acids, arginase and nitric oxide in vascular health. Clin. Exp. Pharmacol. Physiol. 33:1–8 [Google Scholar]
  45. 45. Investig. GISSI-Prev 1999. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 354:447–55 [Google Scholar]
  46. Iso H, Kitamura A, Shimamoto T, Sankai T, Naito Y. 46.  et al. 1995. Alcohol intake and the risk of cardiovascular disease in middle-aged Japanese men. Stroke 26:767–73 [Google Scholar]
  47. Jemai H, Bouaziz M, Fki I, El Feki A, Sayadi S. 47.  2008. Hypolipidimic and antioxidant activities of oleuropein and its hydrolysis derivative-rich extracts from Chemlali olive leaves. Chem.-Biol. Interact. 176:88–98 [Google Scholar]
  48. Jiang R, Jacobs DR, Mayer-Davis E, Szklo M, Herrington D. 48.  et al. 2006. Nut and seed consumption and inflammatory markers in the Multi-Ethnic Study of Atherosclerosis. Am. J. Epidemiol. 163:222–31 [Google Scholar]
  49. Kaluza J, Åkesson A, Wolk A. 49.  2014. Processed and unprocessed red meat consumption and risk of heart failure: a prospective study of men. Circulation 7:552–57 [Google Scholar]
  50. Karatzi K, Papamichael C, Karatzis E, Papaioannou TG, Voidonikola PT. 50.  et al. 2008. Postprandial improvement of endothelial function by red wine and olive oil antioxidants: a synergistic effect of components of the Mediterranean diet. J. Am. Coll. Nutr. 27:448–53 [Google Scholar]
  51. Kastorini CM, Milionis HJ, Esposito K, Giugliano D, Goudevenos JA, Panagiotakos DB. 51.  2011. The effect of Mediterranean diet on metabolic syndrome and its components: a meta-analysis of 50 studies and 534,906 individuals. J. Am. Coll. Cardiol. 57:1299–313 [Google Scholar]
  52. Kastorini CM, Milionis HJ, Kantas D, Bika E, Nikolaou V. 52.  et al. 2012. Adherence to the Mediterranean diet in relation to ischemic stroke nonfatal events in nonhypercholesterolemic and hypercholesterolemic participants: results of a case/case-control study. Angiology 63:509–15 [Google Scholar]
  53. Kelly JH, Sabaté J. 53.  2006. Nuts and coronary heart disease: an epidemiological perspective. Br. J. Nutr. 96:S61–67 [Google Scholar]
  54. Keys A, Arvanis C, Blackburn H, Buzina R, Djordjević BS. 54.  et al. 1980. Seven Countries: A Multivariate Analysis of Death and Coronary Heart Disease Cambridge, MA: Harvard Univ. Press
  55. Kleinbongard P, Dejam A, Lauer T, Jax T, Kerber S. 55.  et al. 2006. Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans. Free Radic. Biol. Med. 40:295–302 [Google Scholar]
  56. Knoops KT, de Groot LC, Kromhout D, Perrin A, Moreiras-Varela O. 56.  et al. 2004. Mediterranean diet, lifestyle factors, and 10-year mortality in elderly European men and women: the HALE project. JAMA 292:1433–39 [Google Scholar]
  57. Kris-Etherton P, Eckel RH, Howard BV, St. Jeor S, Bazzarre TL. 57.  et al. 2001. Lyon Diet Heart Study: benefits of a Mediterranean-style, National Cholesterol Education Program/American Heart Association Step I dietary pattern on cardiovascular disease. Circulation 103:1823–25 [Google Scholar]
  58. Kris-Etherton PM, Harris WS, Appel LJ. 58.  (for Nutr. Comm.) 2002. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 106:2747–57 [Google Scholar]
  59. Kromhout D, Keys A, Aravanis C, Buzina R, Fidanza F. 59.  et al. 1989. Food consumption patterns in the 1960s in seven countries. Am. J. Clin. Nutr. 49:889–94 [Google Scholar]
  60. Lamarche Bt, Moorjani S, Cantin B, Dagenais GR, Lupien PJ, Despre J-P. 60.  1997. Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men: prospective results from the Quebec Cardiovascular Study. Circulation 95:69–75 [Google Scholar]
  61. Langer RD, Criqui MH, Reed DM. 61.  1992. Lipoproteins and blood pressure as biological pathways for effect of moderate alcohol consumption on coronary heart disease. Circulation 85:910–15 [Google Scholar]
  62. Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B. 62.  et al. 2001. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 37:1236–41 [Google Scholar]
  63. Leon AS, Sanchez OA. 63.  2001. Response of blood lipids to exercise training alone or combined with dietary intervention. Med. Sci. Sports Exerc. 33:S502–15; discussion S528–29 [Google Scholar]
  64. Li TY, Brennan AM, Wedick NM, Mantzoros C, Rifai N, Hu FB. 64.  2009. Regular consumption of nuts is associated with a lower risk of cardiovascular disease in women with type 2 diabetes. J. Nutr. 139:1333–38 [Google Scholar]
  65. Lloyd-Jones DM, Wang TJ, Leip EP, Larson MG, Levy D. 65.  et al. 2004. Lifetime risk for development of atrial fibrillation: the Framingham Heart Study. Circulation 110:1042–46 [Google Scholar]
  66. Lorenz MW, Markus HS, Bots ML, Rosvall M, Sitzer M. 66.  2007. Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation 115:459–67 [Google Scholar]
  67. Machowetz A, Poulsen HE, Gruendel S, Weimann A, Fito M. 67.  et al. 2007. Effect of olive oils on biomarkers of oxidative DNA stress in Northern and Southern Europeans. FASEB J. 21:45–52 [Google Scholar]
  68. Margetts BM, Beilin LJ, Vandongen R, Armstrong BK. 68.  1986. Vegetarian diet in mild hypertension: a randomised controlled trial. Br. Med. J. 293:1468 [Google Scholar]
  69. Martínez-González , de la Fuente-Arrillaga C, Nuñez-Cordoba JM, Basterra-Gortari FJ, Beunza JJ. 69.  et al. 2008. Adherence to Mediterranean diet and risk of developing diabetes: prospective cohort study. BMJ 336:1348–51 [Google Scholar]
  70. Martínez-González , Toledo E, Arós F, Fiol M, Corella D. 70.  et al. 2014. Extra-virgin olive oil consumption reduces risk of atrial fibrillation: the PREDIMED Trial. Circulation 130:18–26 [Google Scholar]
  71. Martínez-Lapiscina EH, Clavero P, Toledo E, Estruch R, Salas-Salvadó J. 71.  et al. 2013. Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial. J. Neurol. Neurosurg. Psychiatry 84:1318–25 [Google Scholar]
  72. Mattace-Raso FUS, van der Cammen TJM, Hofman A, van Popele NM, Bos ML. 72.  et al. 2006. Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation 113:657–63 [Google Scholar]
  73. Miles EA, Zoubouli P, Calder PC. 73.  2005. Differential anti-inflammatory effects of phenolic compounds from extra virgin olive oil identified in human whole blood cultures. Nutrition 21:389–94 [Google Scholar]
  74. Mitjavila MT, Fandos M, Salas-Salvadó J, Covas MI, Borrego S. 74.  et al. 2013. The Mediterranean diet improves the systemic lipid and DNA oxidative damage in metabolic syndrome individuals. A randomized, controlled, trial. Clin. Nutr. 32:172–78 [Google Scholar]
  75. Moore RD, Pearson TA. 75.  1986. Moderate alcohol consumption and coronary artery disease: a review. Medicine 65:242–67 [Google Scholar]
  76. Murie-Fernandez M, Irimia P, Toledo E, Martínez-Vila E, Buil-Cosiales P. 76.  et al. 2011. Carotid intima-media thickness changes with Mediterranean diet: a randomized trial (PREDIMED-Navarra). Atherosclerosis 219:158–62 [Google Scholar]
  77. Núñez-Córdoba JM, Valencia-Serrano F, Toledo E, Alonso A, Martínez-González . 77.  2009. The Mediterranean diet and incidence of hypertension: the Seguimiento Universidad de Navarra (SUN) Study. Am. J. Epidemiol. 169:339–46 [Google Scholar]
  78. Pai JK, Mukamal KJ, Rimm EB. 78.  2012. Long-term alcohol consumption in relation to all-cause and cardiovascular mortality among survivors of myocardial infarction: the Health Professionals Follow-up Study. Eur. Heart J. 33:1598–605 [Google Scholar]
  79. Pan A, Sun Q, Bernstein AM, Schulze MB, Manson JE. 79.  et al. 2012. Red meat consumption and mortality: results from 2 prospective cohort studies. Arch. Intern. Med. 172:555–63 [Google Scholar]
  80. Pan X-R, Li G-W, Hu Y-H, Wang J-X, Yang W-Y. 80.  et al. 1997. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance: the Da Qing IGT and Diabetes Study. Diabetes Care 20:537–44 [Google Scholar]
  81. Papamichael CM, Karatzi KN, Papaioannou TG, Karatzis EN, Katsichti P. 81.  et al. 2008. Acute combined effects of olive oil and wine on pressure wave reflections: another beneficial influence of the Mediterranean diet antioxidants?. J. Hypertens. 26:223–29 [Google Scholar]
  82. Pereira EC, Ferderbar S, Bertolami MC, Faludi AA, Monte O. 82.  et al. 2008. Biomarkers of oxidative stress and endothelial dysfunction in glucose intolerance and diabetes mellitus. Clin. Biochem. 41:1454–60 [Google Scholar]
  83. Petroni A, Blasevich M, Salami M, Papini N, Montedoro GF, Galli C. 83.  1995. Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil. Thromb. Res. 78:151–60 [Google Scholar]
  84. Piccini JP, Hammill BG, Sinner MF, Jensen PN, Hernandez AF. 84.  et al. 2012. Incidence and prevalence of atrial fibrillation and associated mortality among Medicare beneficiaries: 1993–2007. Circ. Cardiovasc. Qual. Outcomes 5:85–93 [Google Scholar]
  85. Pitsavos C, Panagiotakos DB, Tzima N, Chrysohoou C, Economou M. 85.  et al. 2005. Adherence to the Mediterranean diet is associated with total antioxidant capacity in healthy adults: the ATTICA study. Am. J. Clin. Nutr. 82:694–99 [Google Scholar]
  86. Powell KE, Thompson PD, Caspersen CJ, Kendrick JS. 86.  1987. Physical activity and the incidence of coronary heart disease. Annu. Rev. Public Health 8:253–87 [Google Scholar]
  87. Psaltopoulou T, Naska A, Orfanos P, Trichopoulos D, Mountokalakis T, Trichopoulou A. 87.  2004. Olive oil, the Mediterranean diet, and arterial blood pressure: the Greek European Prospective Investigation into Cancer and Nutrition (EPIC) Study. Am. J. Clin. Nutr. 80:1012–18 [Google Scholar]
  88. Psaltopoulou T, Sergentanis TN, Panagiotakos DB, Sergentanis IN, Kosti R, Scarmeas N. 88.  2013. Mediterranean diet, stroke, cognitive impairment, and depression: a meta-analysis. Ann. Neurol. 74:580–91 [Google Scholar]
  89. Rajagopalan S, Meng XP, Ramasamy S, Harrison DG, Galis ZS. 89.  1996. Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability. J. Clin. Invest. 98:2572–79 [Google Scholar]
  90. Rallidis LS, Lekakis J, Kolomvotsou A, Zampelas A, Vamvakou G. 90.  et al. 2009. Close adherence to a Mediterranean diet improves endothelial function in subjects with abdominal obesity. Am. J. Clin. Nutr. 90:263–68 [Google Scholar]
  91. Reaven P, Parthasarathy S, Grasse BJ, Miller E, Almazan F. 91.  et al. 1991. Feasibility of using an oleate-rich diet to reduce the susceptibility of low-density lipoprotein to oxidative modification in humans. Am. J. Clin. Nutr. 54:701–6 [Google Scholar]
  92. Renaud S, de Lorgeril M. 92.  1992. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 339:1523–26 [Google Scholar]
  93. Renaud SC, Beswick AD, Fehily AM, Sharp DS, Elwood PC. 93.  1992. Alcohol and platelet aggregation: the Caerphilly Prospective Heart Disease Study. Am. J. Clin. Nutr. 55:1012–17 [Google Scholar]
  94. Richard C, Couture P, Ooi EM, Tremblay AJ, Desroches S. 94.  et al. 2014. Effect of Mediterranean diet with and without weight loss on apolipoprotein B100 metabolism in men with metabolic syndrome. Arterioscler. Thromb. Vasc. Biol. 34:433–38 [Google Scholar]
  95. Rimm EB, Giovannucci EL, Willett WC, Colditz GA, Ascherio A. 95.  et al. 1991. Prospective study of alcohol consumption and risk of coronary disease in men. Lancet 338:464–68 [Google Scholar]
  96. Rimm EB, Klatsky A, Grobbee D, Stampfer MJ. 96.  1996. Review of moderate alcohol consumption and reduced risk of coronary heart disease: Is the effect due to beer, wine, or spirits?. BMJ 312:731–36 [Google Scholar]
  97. Rocca AS, LaGreca J, Kalitsky J, Brubaker PL. 97.  2001. Monounsaturated fatty acid diets improve glycemic tolerance through increased secretion of glucagon-like peptide-1. Endocrinology 142:1148–55 [Google Scholar]
  98. Ronksley PE, Brien SE, Turner BJ, Mukamal KJ, Ghali WA. 98.  2011. Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis. BMJ342
  99. Ros E. 99.  2009. Nuts and novel biomarkers of cardiovascular disease. Am. J. Clin. Nutr. 89:1649–56S [Google Scholar]
  100. Ros E, Martínez-González , Estruch R, Salas-Salvadó J, Fitó M. 100.  et al. 2014. Mediterranean diet and cardiovascular health: teachings of the PREDIMED study. Adv. Nutr. 5:330–36S [Google Scholar]
  101. Ros E, Mataix J. 101.  2006. Fatty acid composition of nuts—implications for cardiovascular health. Br. J. Nutr. 96:S29–35 [Google Scholar]
  102. Rossi M, Turati F, Lagiou P, Trichopoulos D, Augustin LS. 102.  et al. 2013. Mediterranean diet and glycaemic load in relation to incidence of type 2 diabetes: results from the Greek cohort of the population-based European Prospective Investigation into Cancer and Nutrition (EPIC). Diabetologia 56:2405–13 [Google Scholar]
  103. Ruano J, Lopez-Miranda J, Fuentes F, Moreno JA, Bellido C. 103.  et al. 2005. Phenolic content of virgin olive oil improves ischemic reactive hyperemia in hypercholesterolemic patients. J. Am. Coll. Cardiol. 46:1864–68 [Google Scholar]
  104. Sacks FM, Castelli WP, Donner A, Kass EH. 104.  1975. Plasma lipids and lipoproteins in vegetarians and controls. N. Engl. J. Med. 292:1148–51 [Google Scholar]
  105. Sala-Vila A, Romero-Mamani ES, Gilabert R, Nunez I, de la Torre R. 105.  et al. 2014. Changes in ultrasound-assessed carotid intima-media thickness and plaque with a Mediterranean diet: a substudy of the PREDIMED trial. Arterioscler. Thromb. Vasc. Biol. 34:439–45 [Google Scholar]
  106. Salas-Salvadó J, Bulló M, Babio N, Martínez-González , Ibarrola-Jurado N. 106.  et al. 2011. Reduction in the incidence of type 2 diabetes with the Mediterranean diet results of the PREDIMED-Reus nutrition intervention randomized trial. Diabetes Care 34:14–19 [Google Scholar]
  107. Salas-Salvadó J, Fernández-Ballart J, Ros E, Martínez-González MA, Fitó M. 107.  et al. 2008. Effect of a Mediterranean diet supplemented with nuts on metabolic syndrome status: one-year results of the PREDIMED randomized trial. Arch. Intern. Med. 168:2449–58 [Google Scholar]
  108. Salmerón J, Hu FB, Manson JE, Stampfer MJ, Colditz GA. 108.  et al. 2001. Dietary fat intake and risk of type 2 diabetes in women. Am. J. Clin. Nutr. 73:1019–26 [Google Scholar]
  109. Scarmeas N, Luchsinger JA, Stern Y, Gu Y, He J. 109.  et al. 2011. Mediterranean diet and magnetic resonance imaging-assessed cerebrovascular disease. Ann. Neurol. 69:257–68 [Google Scholar]
  110. Schulze MB, Schulz M, Heidemann C, Schienkiewitz A, Hoffmann K, Boeing H. 110.  2007. Fiber and magnesium intake and incidence of type 2 diabetes: a prospective study and meta-analysis. Arch. Intern. Med. 167:956–65 [Google Scholar]
  111. Segura R, Javierre C, Lizarraga MA, Ros E. 111.  2006. Other relevant components of nuts: phytosterols, folate and minerals. Br. J. Nutr. 96:S36–44 [Google Scholar]
  112. Sidhu KS. 112.  2003. Health benefits and potential risks related to consumption of fish or fish oil. Regul. Toxicol. Pharmacol. 38:336–44 [Google Scholar]
  113. Simes RJ, Marschner IC, Hunt D, Colquhoun D, Sullivan D. 113.  et al. 2002. Relationship between lipid levels and clinical outcomes in the Long-term Intervention with Pravastatin in Ischemic Disease (LIPID) Trial: To what extent is the reduction in coronary events with pravastatin explained by on-study lipid levels?. Circulation 105:1162–69 [Google Scholar]
  114. Singh RB, Dubnov G, Niaz MA, Ghosh S, Singh R. 114.  et al. 2002. Effect of an Indo-Mediterranean diet on progression of coronary artery disease in high risk patients (Indo-Mediterranean Diet Heart Study): a randomised single-blind trial. Lancet 360:1455–61 [Google Scholar]
  115. Singh RB, Niaz MA, Sharma JP, Kumar R, Rastogi V, Moshiri M. 115.  1997. Randomized, double-blind, placebo-controlled trial of fish oil and mustard oil in patients with suspected acute myocardial infarction: the Indian experiment of infarct survival—4. Cardiovasc. Drugs Ther. 11:485–91 [Google Scholar]
  116. Sofi F, Abbate R, Gensini GF, Casini A. 116.  2010. Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis. Am. J. Clin. Nutr. 92:1189–96 [Google Scholar]
  117. Sofi F, Cesari F, Abbate R, Gensini GF, Casini A. 117.  2008. Adherence to Mediterranean diet and health status: meta-analysis. BMJ 337:a1344 [Google Scholar]
  118. Sofi F, Vecchio S, Giuliani G, Marcucci R, Gori A. 118.  et al. 2005. Dietary habits, lifestyle and cardiovascular risk factors in a clinically healthy Italian population: the “Florence” diet is not Mediterranean. Eur. J. Clin. Nutr. 59:584–91 [Google Scholar]
  119. Stampfer MJ, Colditz GA, Willett WC, Speizer FE, Hennekens CH. 119.  1988. A prospective study of moderate alcohol consumption and the risk of coronary disease and stroke in women. N. Engl. J. Med. 319:267–73 [Google Scholar]
  120. Story M, Neumark-Sztainer D. 120.  2005. A perspective on family meals: Do they matter?. Nutr. Today 40:261–66 [Google Scholar]
  121. Szeto YT, Kwok TC, Benzie IF. 121.  2004. Effects of a long-term vegetarian diet on biomarkers of antioxidant status and cardiovascular disease risk. Nutrition 20:863–66 [Google Scholar]
  122. Thom TJ, Epstein FH, Feldman JJ, Leaverton PE. 122.  1985. Trends in total mortality and mortality from heart disease in 26 countries from 1950 to 1978. Int. J. Epidemiol. 14:510–20 [Google Scholar]
  123. Thompson PD, Buchner D, Piña IL, Balady GJ, Williams MA. 123.  et al. 2003. Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: a statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity). Circulation 107:3109–16 [Google Scholar]
  124. Thompson PD, Crouse SF, Goodpaster B, Kelley D, Moyna N, Pescatello L. 124.  2001. The acute versus the chronic response to exercise. Med. Sci. Sports Exerc. 33:S438–45; discussion S452–53 [Google Scholar]
  125. Toledo E, Delgado-Rodríguez M, Estruch R, Salas-Salvadó J, Corella D. 125.  et al. 2009. Low-fat dairy products and blood pressure: follow-up of 2290 older persons at high cardiovascular risk participating in the PREDIMED study. Br. J. Nutr. 101:59–67 [Google Scholar]
  126. Tortosa A, Bes-Rastrollo M, Sanchez-Villegas A, Basterra-Gortari FJ, Nuñez-Cordoba JM, Martínez-González . 126.  2007. Mediterranean diet inversely associated with the incidence of metabolic syndrome: the SUN prospective cohort. Diabetes Care 30:2957–59 [Google Scholar]
  127. Trichopoulou A, Costacou T, Bamia C, Trichopoulos D. 127.  2003. Adherence to a Mediterranean diet and survival in a Greek population. N. Engl. J. Med. 348:2599–608 [Google Scholar]
  128. Tripoli E, Giammanco M, Tabacchi G, Di Majo D, Giammanco S, La Guardia M. 128.  2005. The phenolic compounds of olive oil: structure, biological activity and beneficial effects on human health. Nutr. Res. Rev. 18:98–112 [Google Scholar]
  129. van de Laar RJ, Stehouwer CD, van Bussel BC, Prins MH, Twisk JW, Ferreira I. 129.  2013. Adherence to a Mediterranean dietary pattern in early life is associated with lower arterial stiffness in adulthood: the Amsterdam Growth and Health Longitudinal Study. J. Intern. Med. 273:79–93 [Google Scholar]
  130. Van Leer EM, Seidell JC, Kromhout D. 130.  1995. Dietary calcium, potassium, magnesium and blood pressure in the Netherlands. Int. J. Epidemiol. 24:1117–23 [Google Scholar]
  131. Vincent-Baudry S, Defoort C, Gerber M, Bernard MC, Verger P. 131.  et al. 2005. The Medi-RIVAGE study: reduction of cardiovascular disease risk factors after a 3-mo intervention with a Mediterranean-type diet or a low-fat diet. Am. J. Clin. Nutr. 82:964–71 [Google Scholar]
  132. Watson KE, Abrolat ML, Malone LL, Hoeg JM, Doherty T. 132.  et al. 1997. Active serum vitamin D levels are inversely correlated with coronary calcification. Circulation 96:1755–60 [Google Scholar]
  133. Wengreen H, Munger RG, Cutler A, Quach A, Bowles A. 133.  et al. 2013. Prospective study of dietary approaches to stop hypertension- and Mediterranean-style dietary patterns and age-related cognitive change: the Cache County Study on Memory, Health and Aging. Am. J. Clin. Nutr. 98:1263–71 [Google Scholar]
  134. 134. WHO (World Health Organ.) 2003. Diet, nutrition and the prevention of chronic diseases. WHO Tech. Rep. Ser. 9161–149 Geneva: WHO [Google Scholar]
  135. Willett WC. 135.  1994. Diet and health: What should we eat?. Science 264:532–37 [Google Scholar]
  136. Willett WC, Sacks F, Trichopoulou A, Drescher G, Ferro-Luzzi A. 136.  et al. 1995. Mediterranean diet pyramid: a cultural model for healthy eating. Am. J. Clin. Nutr. 61:1402–6S [Google Scholar]
  137. Wing RR, Hill JO. 137.  2001. Successful weight loss maintenance. Annu. Rev. Nutr. 21:323–41 [Google Scholar]
  138. Wolf PA, Abbott RD, Kannel WB. 138.  1987. Atrial fibrillation: a major contributor to stroke in the elderly: the Framingham Study. Arch. Intern. Med. 147:1561–64 [Google Scholar]
  139. Wu JM, Wang Z-R, Hsieh T-C, Bruder JL, Zou J-G, Huang Y-Z. 139.  2001. Mechanism of cardioprotection by resveratrol, a phenolic antioxidant present in red wine (review). Int. J. Mol. Med. 8:3–17 [Google Scholar]
  140. Xin X, He J, Frontini MG, Ogden LG, Motsamai OI, Whelton PK. 140.  2001. Effects of alcohol reduction on blood pressure: a meta-analysis of randomized controlled trials. Hypertension 38:1112–17 [Google Scholar]
  141. Young SG. 141.  1990. Recent progress in understanding apolipoprotein B. Circulation 82:1574–94 [Google Scholar]
  142. Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A. 142.  et al. 2004. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 364:937–52 [Google Scholar]
  143. Zemel MB. 143.  2001. Calcium modulation of hypertension and obesity: mechanisms and implications. J. Am. Coll. Nutr. 20:428–35S [Google Scholar]
  144. Zemel MB, Thompson W, Milstead A, Morris K, Campbell P. 144.  2004. Calcium and dairy acceleration of weight and fat loss during energy restriction in obese adults. Obes. Res. 12:582–90 [Google Scholar]
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