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Annual Review of Neuroscience

Volume 45, 2022

Melding Synthetic Molecules and Genetically Encoded Proteins to Forge New Tools for Neuroscience

Abstract

Unraveling the complexity of the brain requires sophisticated methods to probe and perturb neurobiological processes with high spatiotemporal control. The field of chemical biology has produced general strategies to combine the molecular specificity of small-molecule tools with the cellular specificity of genetically encoded reagents. Here, we survey the application, refinement, and extension of these hybrid small-molecule:protein methods to problems in neuroscience, which yields powerful reagents to precisely measure and manipulate neural systems.

Keyword(s): cell-specific pharmacology, chemical biology, chemistry, functional imaging, neuroscience, protein engineering
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/content/journals/10.1146/annurev-neuro-110520-030031
2022-07-08
2024-04-23
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Melding Synthetic Molecules and Genetically Encoded Proteins to Forge New Tools for Neuroscience
Annual Review of Neuroscience 45, 131 (2022); https://doi.org/10.1146/annurev-neuro-110520-030031
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  • Article Type: Review Article

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