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Figure 1 
Spatial metabolic liver zonation. () Architecture of the liver lobule, as described in Section 1 of the main text. () Spatial physiological organization of the liver, as described in Section 2 of the main text. Higher periportal availability of hormones and gradients of oxygen and WNT/β-catenin activity promote spatial liver zonation. Upper inset illustrates how local availability of RSPO and WNT ligands around the central vein induces spatially confined pathway activity. Lower inset illustrates fenestrated sinusoidal endothelium enabling uptake of substances by hepatocytes and release of metabolites back into the porto-central blood flow. () Selection of spatially zonated metabolic processes.
pathol/18/1/pm180439.f1_thmb.gif
pathol/18/1/pm180439.f1.gif
image of Figure 1 
Figure 1  Spatial metabolic liver zonation. () Architecture of the liver lobule, as described in Section 1 of the main text. () Spatial physiological organization of the liver, as described in Section 2 of the main text. Higher periportal availability of hormones and gradients of oxygen and WNT/β-catenin activity promote spatial liver zonation. Upper inset illustrates how local availability of RSPO and WNT ligands around the central vein induces spatially confined pathway activity. Lower inset illustrates fenestrated sinusoidal endothelium enabling uptake of substances by hepatocytes and release of metabolites back into the porto-central blood flow. () Selection of spatially zonated metabolic processes. Copyright © 2023 by the author(s).
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