
Figure 3
Spatiotemporal hepatic gene expression in mice. (a) Changes in gene expression in lobular space (x-axis) and time (y-axis) shown as the standard deviation of log2 mRNA expression. Examples of detoxification genes (left panel) and monogenic disease genes (right panel) are shown. The distance from zero corresponds to higher expression changes along the lobular axis or along the duration of one day, respectively. (b,c) Agxt shown as an example gene where mRNA expression changes with both lobular space (b) and circadian time (c). Abbreviations: SD, standard deviation; ZT, Zeitgeber time. Figure adapted from Reference 18.
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