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Annual Review of Analytical Chemistry

Volume 18, 2025

Analytic Approaches to Physicochemical Properties of Materials for Biomedical Applications Across Nanoscopic and Macroscopic Length Scales

  • Farnaz Fazelpour1, Lindsey C. Hill1,2, Matthew R. Markovetz1 and David B. Hill1,2,3
  • 1Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; email: [email protected] 2Joint Department of Biomedical Engineering, North Carolina State University and University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA 3Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
  • Vol. 18:473-495 (Volume publication date May 2025)
  • First published as a Review in Advance on February 14, 2025
  • Copyright © 2025 by the author(s).
    This work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See credit lines of images or other third-party material in this article for license information.

Abstract

The design and implementation of biomedical devices for both diagnostic and direct medical applications have revolutionized patient care, paving the way for improved patient outcomes. Understanding the characteristics of materials used in the design of new devices is essential for their advancement. In this review, our goal is to assist biomedical researchers in appreciating the importance of these properties and the role of selecting the proper measurement. We discuss how the nanoscopic molecular composition, arrangement, and interactions generate the properties of liquids, solids, viscoelastic materials, and colloids and discuss the measurement techniques that can be used to assess these properties from the nanoscale to the macroscale. We explore the linear and nonlinear mechanical responses of materials, elucidate their behaviors under varying conditions, and discuss corresponding measurement techniques. Finally, we highlight the importance of tailoring measurements to the underlying biological processes and applications being investigated.

Keyword(s): biomaterials, colloid, physical properties, rheology, viscoelastic
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2025-05-15
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Analytic Approaches to Physicochemical Properties of Materials for Biomedical Applications Across Nanoscopic and Macroscopic Length Scales
Annual Review of Analytical Chemistry 18, 473 (2025); https://doi.org/10.1146/annurev-anchem-061622-015821
/content/journals/10.1146/annurev-anchem-061622-015821
/content/journals/10.1146/annurev-anchem-061622-015821
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