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Annual Review of Animal Biosciences

Volume 13, 2025

A Passion for Small Things and Staying Primed: My Career in Virology and Immunology

  • Linda J. Saif1
  • Center for Food Animal Health, Animal Sciences Department, Ohio Agricultural Research and Development Center, College of Food, Agriculture and Environmental Sciences, and Veterinary Preventive Medicine Department, College of Veterinary Medicine, The Ohio State University, Wooster, Ohio, USA; email: [email protected]
  • Vol. 13:1-24 (Volume publication date February 2025)
  • First published as a Review in Advance on November 15, 2024
  • Copyright © 2025 by the author(s).
    This work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See credit lines of images or other third-party material in this article for license information.

Abstract

A love of science and animals, perseverance, and happenstance propelled my career in veterinary virology and immunology. I have focused on deadly enteric and respiratory viral infections in neonatal livestock and humans with an aim to understand their prevalence, pathogenesis, interspecies transmission, and immunity and develop vaccines. Research on animal coronaviruses (CoVs), including their broad interspecies transmission, provided a foundation to understand emerging zoonotic fatal human respiratory CoVs [severe acute respiratory syndrome, Middle East respiratory syndrome, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)] and reverse zoonosis of SARS-CoV-2 to animals. A highlight of my early research was the discovery of the gut–mammary gland–sIgA axis, documenting a common mucosal immune system. The latter remains pivotal to designing maternal vaccines for passive immunity in neonates. Our discovery and innovative cell propagation of fastidious human and animal rotaviruses and caliciviruses and their infectivity in germ-free animals has provided cell-adapted and animal disease models for ongoing virologic and immunologic investigations and vaccines. Nevertheless, besides the research discoveries, my lasting legacy remains the outstanding mentees who have enriched my science and my life.

Keyword(s): autobiography, caliciviruses, coronaviruses, mucosal immunity, passive immunity, rotaviruses
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2025-02-18
2025-06-21
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/content/journals/10.1146/annurev-animal-111523-101937
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A Passion for Small Things and Staying Primed: My Career in Virology and Immunology
Annual Review of Animal Biosciences 13, 1 (2025); https://doi.org/10.1146/annurev-animal-111523-101937
/content/journals/10.1146/annurev-animal-111523-101937
/content/journals/10.1146/annurev-animal-111523-101937
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