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Annual Review of Plant Biology

Volume 76, 2025

Monkeys at Rigged Typewriters: A Population and Network View of Plant Immune System Incompatibility

  • Rachelle R.Q. Lee1 and Eunyoung Chae1,2
  • 1Department of Biological Sciences, National University of Singapore, Singapore; email: [email protected] 2Department of Biology, University of Oxford, Oxford, United Kingdom; email: [email protected]
  • Vol. 76:523-550 (Volume publication date May 2025)
  • First published as a Review in Advance on March 03, 2025
  • Copyright © 2025 by the author(s).
    This work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See credit lines of images or other third-party material in this article for license information.

Abstract

Immune system incompatibilities between naturally occurring genomic variants underlie many hybrid defects in plants and present a barrier for crop improvement. In this review, we approach immune system incompatibilities from pan-genomic and network perspectives. Pan-genomes offer insights into how natural variation shapes the evolutionary landscape of immune system incompatibilities, and through it, selection, polymorphisms, and recombination resistance emerge as common features that synergistically drive these incompatibilities. By contextualizing incompatibilities within the immune network, immune receptor promiscuity, complex dysregulation, and single-point failure appear to be recurrent themes of immune system defects. As geneticists break genes to investigate their function, so can we investigate broken immune systems to enrich our understanding of plant immune systems and work toward improving them.

Keyword(s): autoimmunity, genetic incompatibility, hybrid necrosis, network, NLR, plant immunity
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2025-05-20
2025-06-16
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Monkeys at Rigged Typewriters: A Population and Network View of Plant Immune System Incompatibility
Annual Review of Plant Biology 76, 523 (2025); https://doi.org/10.1146/annurev-arplant-083023-041225
/content/journals/10.1146/annurev-arplant-083023-041225
/content/journals/10.1146/annurev-arplant-083023-041225
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