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Annual Review of Cell and Developmental Biology

Volume 40, 2024

Adaptive Cellular Radiations and the Genetic Mechanisms Underlying Animal Nervous System Diversification

Abstract

In animals, the nervous system evolved as the primary interface between multicellular organisms and the environment. As organisms became larger and more complex, the primary functions of the nervous system expanded to include the modulation and coordination of individual responsive cells via paracrine and synaptic functions as well as to monitor and maintain the organism's own internal environment. This was initially accomplished via paracrine signaling and eventually through the assembly of multicell circuits in some lineages. Cells with similar functions and centralized nervous systems have independently arisen in several lineages. We highlight the molecular mechanisms that underlie parallel diversifications of the nervous system.

Keyword(s): cell type, cnidarian, evolution, genetic networks, neuron, pleiotropy
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/content/journals/10.1146/annurev-cellbio-111822-124041
2024-10-02
2025-04-27
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Adaptive Cellular Radiations and the Genetic Mechanisms Underlying Animal Nervous System Diversification
Annual Review of Cell and Developmental Biology 40, 407 (2024); https://doi.org/10.1146/annurev-cellbio-111822-124041
/content/journals/10.1146/annurev-cellbio-111822-124041
/content/journals/10.1146/annurev-cellbio-111822-124041
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