1932

Abstract

Although rates of child maltreatment are declining, more than 600,000 children in the United States are substantiated victims of abuse or neglect. The focus of this review is on the relationship between maltreatment and mental health problems in childhood and adulthood. Children and adults who are exposed to abuse or neglect in childhood are at risk for a range of poor mental health outcomes, including internalizing and externalizing psychopathology, posttraumatic stress disorder, psychotic symptoms, and personality disorders. I review three potential mechanisms by which maltreatment may increase risk for various forms of psychopathology, () hypervigilance to threat, () deficits in emotion recognition and understanding, and () low responsivity to reward. I also review genetic and psychosocial factors that moderate the relationship between maltreatment and risk for psychopathology. Finally, I discuss methodological limitations of the literature on maltreatment, with an emphasis on the challenges associated with establishing a causal role for maltreatment (and moderators or mediators of maltreatment) in the development of mental health problems and the reliance of many studies on retrospective self-reports.

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2017-05-08
2024-04-19
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Literature Cited

  1. Ahrens KR, DuBois DL, Richardson LP, Fan M-Y, Lozano P. 2008. Youth in foster care with adult mentors during adolescence have improved adult outcomes. Pediatrics 121:2e246–52 https://doi.org/10.1542/peds.2007-0508 [Google Scholar]
  2. Alexander N, Klucken T, Koppe G, Osinsky R, Walter B. et al. 2012. Interaction of the serotonin transporter-linked polymorphic region and environmental adversity: increased amygdala-hypothalamus connectivity as a potential mechanism linking neural and endocrine hyperreactivity. Biol. Psychiatry 72:149–56 [Google Scholar]
  3. Alexander N, Kuepper Y, Schmitz A, Osinsky R, Kozyra E, Hennig J. 2009. Gene-environment interactions predict cortisol responses after acute stress: implications for the etiology of depression. Psychoneuroendocrinology 34:91294–303 [Google Scholar]
  4. Alia-Klein N, Goldstein RZ, Kriplani A, Logan J, Tomasi D. et al. 2008. Brain monoamine oxidase A activity predicts trait aggression. J. Neurosci. 28:195099–104 [Google Scholar]
  5. Alia-Klein N, Goldstein RZ, Tomasi D, Woicik PA, Moeller SJ. et al. 2009. Neural mechanisms of anger regulation as a function of genetic risk for violence. Emotion 9:3385–96 https://doi.org/10.1037/a0015904 [Google Scholar]
  6. Aliev F, Latendresse SJ, Bacanu S-A, Neale MC, Dick DM. 2014. Testing for measured gene-environment interaction: problems with the use of cross-product terms and a regression model reparameterization solution. Behav. Genet. 44:2165–81 https://doi.org/10.1007/s10519-014-9642-1 [Google Scholar]
  7. Armour C, Műllerová J, Elhai JD. 2016. A systematic literature review of PTSD's latent structure in the Diagnostic and Statistical Manual of Mental Disorders: DSM-IV to DSM-5. Clin. Psychol. Rev. 44:60–74 https://doi.org/10.1016/j.cpr.2015.12.003 [Google Scholar]
  8. Arseneault L, Cannon M, Fisher HL, Polanczyk G, Moffitt TE, Caspi A. 2011. Childhood trauma and children's emerging psychotic symptoms: a genetically sensitive longitudinal cohort study. Am. J. Psychiatry 168:65–72 [Google Scholar]
  9. Bar-Haim Y, Lamy D, Pergamin L, Bakermans-Kranenburg MJ, van IJzendoorn MH. 2007. Threat-related attentional bias in anxious and nonanxious individuals: a meta-analytic study. Psychol. Bull. 133:11–24 https://doi.org/10.1037/0033-2909.133.1.1 [Google Scholar]
  10. Beevers CG, Wells TT, Ellis AJ, McGeary JE. 2009. Association of the serotonin transporter gene promoter region (5-HTTLPR) polymorphism with biased attention for emotional stimuli. J. Abnorm. Psychol. 118:3670–81 [Google Scholar]
  11. Berridge KC, Robinson TE. 2003. Parsing reward. Trends Neurosci 26:9507–13 https://doi.org/10.1016/S0166-2236(03)00233-9 [Google Scholar]
  12. Bolger KE, Patterson CJ. 2001. Pathways from child maltreatment to internalizing problems: perceptions of control as mediators and moderators. Dev. Psychopathol. 13:4913–40 [Google Scholar]
  13. Breslau N, Koenen KC, Luo Z, Agnew-Blais J, Swanson S. et al. 2014. Childhood maltreatment, juvenile disorders and adult post-traumatic stress disorder: a prospective investigation. Psychol. Med. 44:91937–45 https://doi.org/10.1017/S0033291713002651 [Google Scholar]
  14. Briggs-Gowan MJ, Pollak SD, Grasso D, Voss J, Mian ND. et al. 2015. Attention bias and anxiety in young children exposed to family violence. J. Child Psychol. Psychiatry 56:111194–201 https://doi.org/10.1111/jcpp.12397 [Google Scholar]
  15. Brown J, Cohen P, Johnson JG, Smailes EM. 1999. Childhood abuse and neglect: specificity of effects on adolescent and young adult depression and suicidality. J. Am. Acad. Child Adolesc. Psychiatry 38:121490–96 [Google Scholar]
  16. Brownell CA, Svetlova M, Anderson R, Nichols SR, Drummond J. 2013. Socialization of early prosocial behavior: Parents’ talk about emotions is associated with sharing and helping in toddlers. Infancy 18:191–119 https://doi.org/10.1111/j.1532-7078.2012.00125.x [Google Scholar]
  17. Brunner HG, Nelen M, Breakefield XO, Ropers HH, van Oost BA. 1993. Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 262:578–80 [Google Scholar]
  18. Byrd AL, Manuck SB. 2014. MAOA, childhood maltreatment, and antisocial behavior: meta-analysis of a gene-environment interaction. Biol. Psychiatry 75:19–17 https://doi.org/10.1016/j.biopsych.2013.05.004 [Google Scholar]
  19. Camras LA, Grow JG, Ribordy SC. 1983. Recognition of emotional expression by abused children. J. Clin. Child Psychol. 12:3325–28 https://doi.org/10.1207/s15374424jccp1203_16 [Google Scholar]
  20. Canli T, Qiu M, Omura K, Congdon E, Haas BW. et al. 2006. Neural correlates of epigenesis. PNAS 103:4316033–38 [Google Scholar]
  21. Caspi A, Hariri AR, Holmes A, Uher R, Moffitt TE. 2010. Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am. J. Psychiatry 167:5509–27 [Google Scholar]
  22. Caspi A, McClay J, Moffitt TE, Mill J, Martin J. et al. 2002. Role of genotype in the cycle of violence in maltreated children. Science 297:851–54 [Google Scholar]
  23. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW. et al. 2003. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 31:386–89 [Google Scholar]
  24. Checknita D, Maussion G, Labonté B, Comai S, Tremblay RE. et al. 2015. Monoamine oxidase A gene promoter methylation and transcriptional downregulation in an offender population with antisocial personality disorder. Br. J. Psychiatry 206:3216–22 https://doi.org/10.1192/bjp.bp.114.144964 [Google Scholar]
  25. Cicchetti D, Curtis WJ. 2005. An event-related potential study of the processing of affective facial expressions in young children who experienced maltreatment during the first year of life. Dev. Psychopathol. 17:3641–77 [Google Scholar]
  26. Cicchetti D, Rogosch FA. 1997. The role of self-organization in the promotion of resilience in maltreated children. Dev. Psychopathol. 9:797–815 [Google Scholar]
  27. Cicchetti D, Rogosch FA, Lynch M, Holt KD. 1993. Resilience in maltreated children: processes leading to adaptive outcome. Dev. Psychopathol. 5:4629–47 [Google Scholar]
  28. Clemens B, Voß B, Pawliczek C, Mingoia G, Weyer D. et al. 2015. Effect of MAOA genotype on resting-state networks in healthy participants. Cereb. Cortex 25:71771–81 https://doi.org/10.1093/cercor/bht366 [Google Scholar]
  29. Cline JI, Belsky J, Li Z, Melhuish E, Lysenko L. et al. 2015. Take your mind off it: coping style, serotonin transporter linked polymorphic region genotype (5-HTTLPR), and children's internalizing and externalizing problems. Dev. Psychopathol. 27:4 Part 11129–43 https://doi.org/10.1017/S0954579415000723 [Google Scholar]
  30. Cohen P, Brown J, Smailes E. 2001. Child abuse and neglect and the development of mental disorders in the general population. Dev. Psychopathol. 13:4981–99 [Google Scholar]
  31. Collishaw S, Pickles A, Messer J, Rutter M, Shearer C, Maughan B. 2007. Resilience to adult psychopathology following childhood maltreatment: evidence from a community sample. Child Abus. Negl. 31:3211–29 https://doi.org/10.1016/j.chiabu.2007.02.004 [Google Scholar]
  32. Colman I, Kingsbury M, Garad Y, Zeng Y, Naicker K. et al. 2016. Consistency in adult reporting of adverse childhood experiences. Psychol. Med. 46:3543–49 https://doi.org/10.1017/S0033291715002032 [Google Scholar]
  33. Conger RD, Schofield TJ, Neppl TK, Merrick MT. 2013. Disrupting intergenerational continuity in harsh and abusive parenting: the importance of a nurturing relationship with a romantic partner. J. Adolesc. Health 53:4S11–17 https://doi.org/10.1016/j.jadohealth.2013.03.014 [Google Scholar]
  34. Conway CC, Hammen C, Espejo EP, Wray NR, Najman JM, Brennan PA. 2012. Appraisals of stressful life events as a genetically-linked mechanism in the stress-depression relationship. Cogn. Ther. Res. 36:4338–47 [Google Scholar]
  35. Crick NR, Dodge KA. 1994. A review and reformulation of social information-processing mechanisms in children's social adjustment. Psychol. Bull. 115:174–101 [Google Scholar]
  36. Crusto CA, Whitson ML, Walling SM, Feinn R, Friedman SR. et al. 2010. Posttraumatic stress among young urban children exposed to family violence and other potentially traumatic events. J. Trauma. Stress 23:6716–24 [Google Scholar]
  37. Curtis WJ, Cicchetti D. 2011. Affective facial expression processing in young children who have experienced maltreatment during the first year of life: an event-related potential study. Dev. Psychopathol. 23:2373–95 [Google Scholar]
  38. Danese A, McEwen BS. 2012. Adverse childhood experiences, allostasis, allostatic load, and age-related disease. Physiol. Behav. 106:129–39 [Google Scholar]
  39. Dannlowski U, Stuhrmann A, Beutelmann V, Zwanzger P, Lenzen T. et al. 2012. Limbic scars: long-term consequences of childhood maltreatment revealed by functional and structural magnetic resonance imaging. Biol. Psychiatry 71:4286–93 [Google Scholar]
  40. Denson TF, Dobson-Stone C, Ronay R, von Hippel W, Schira MM. 2014. A functional polymorphism of the MAOA gene is associated with neural responses to induced anger control. J. Cogn. Neurosci. 26:71418–27 https://doi.org/10.1162/jocn_a_00592 [Google Scholar]
  41. Dillon DG, Holmes AJ, Birk JL, Brooks N, Lyons-Ruth K, Pizzagalli DA. 2009. Childhood adversity is associated with left basal ganglia dysfunction during reward anticipation in adulthood. Biol. Psychiatry 66:3206–13 [Google Scholar]
  42. Dingfelder HE, Jaffee SR, Mandell DS. 2010. The impact of social support on depressive symptoms among adolescents in the child welfare system: a propensity score analysis. Child. Youth Serv. Rev. 32:101255–61 [Google Scholar]
  43. Dodge KA. 1993. Social-cognitive mechanisms in the development of conduct disorder and depression. Annu. Rev. Psychol. 44:559–84 [Google Scholar]
  44. Dodge KA, Pettit GS, Bates JE, Valente E. 1995. Social information-processing patterns partially mediate the effect of early physical abuse on later conduct problems. J. Abnorm. Psychol. 104:632–43 [Google Scholar]
  45. Duman EA, Canli T. 2015. Influence of life stress, 5-HTTLPR genotype, and SLC6A4 methylation on gene expression and stress response in healthy Caucasian males. Biol. Mood Anxiety Disord. 5:2 https://doi.org/10.1186/s13587-015-0017-x [Google Scholar]
  46. Dumont KA, Widom CS, Czaja SJ. 2007. Predictors of resilience in abused and neglected children grown-up: the role of individual and neighborhood characteristics. Child Abus. Negl. 31:3255–74 [Google Scholar]
  47. Duncan LE, Keller MC. 2011. A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry. Am. J. Psychiatry 168:101041–49 [Google Scholar]
  48. Dunlop BW, Nemeroff CB. 2007. The role of dopamine in the pathophysiology of depression. Arch. Gen. Psychiatry 64:3327–37 https://doi.org/10.1001/archpsyc.64.3.327 [Google Scholar]
  49. During SM, McMahon RJ. 1991. Recognition of emotional facial expressions by abusive mothers and their children. J. Clin. Child Psychol. 20:2132–39 [Google Scholar]
  50. Esposito CL, Clum GA. 2002. Social support and problem-solving as moderators of the relationship between childhood abuse and suicidality: applications to a delinquent population. J. Trauma. Stress 15:2137–46 https://doi.org/10.1023/A:1014860024980 [Google Scholar]
  51. Famularo R, Kinscherff R, Fenton T. 1992. Psychiatric diagnoses of maltreated children: preliminary findings. J. Am. Acad. Child Adolesc. Psychiatry 31:5863–67 [Google Scholar]
  52. Fan J, Fossella J, Sommer T, Wu Y, Posner MI. 2003. Mapping the genetic variation of executive attention onto brain activity. PNAS 100:127406–11 https://doi.org/10.1073/pnas.0732088100 [Google Scholar]
  53. Fani N, Bradley-Davino B, Ressler KJ, McClure-Tone EB. 2011. Attention bias in adult survivors of childhood maltreatment with and without posttraumatic stress disorder. Cogn. Ther. Res. 35:157–67 https://doi.org/10.1007/s10608-010-9294-2 [Google Scholar]
  54. Feiring C, Taska L, Lewis M. 2002. Adjustment following sexual abuse discovery: the role of shame and attributional style. Dev. Psychol. 38:179–92 [Google Scholar]
  55. Folger SF, Wright MO. 2013. Altering risk following child maltreatment: family and friend support as protective factors. J. Fam. Violence 28:4325–37 https://doi.org/10.1007/s10896-013-9510-4 [Google Scholar]
  56. Fonzo GA, Ramsawh HJ, Flagan TM, Simmons AN, Sullivan SG. et al. 2016. Early life stress and the anxious brain: evidence for a neural mechanism linking childhood emotional maltreatment to anxiety in adulthood. Psychol. Med. 46:51037–54 https://doi.org/10.1017/S0033291715002603 [Google Scholar]
  57. Fossella J, Sommer T, Fan J, Wu Y, Swanson JM. et al. 2002. Assessing the molecular genetics of attention networks. BMC Neurosci 3:14 https://doi.org/10.1186/1471-2202-3-14 [Google Scholar]
  58. Gagne M-H, Melancon C. 2013. Parental psychological violence and adolescent behavioral adjustment: the role of coping and social support. J. Interpers. Violence 28:1176–200 https://doi.org/10.1177/0886260512448842 [Google Scholar]
  59. Gayer-Anderson C, Fisher HL, Fearon P, Hutchinson G, Morgan K. et al. 2015. Gender differences in the association between childhood physical and sexual abuse, social support and psychosis. Soc. Psychiatry Psychiatr. Epidemiol. 50:101489–500 https://doi.org/10.1007/s00127-015-1058-6 [Google Scholar]
  60. Gibb BE, Beevers CG, McGeary JE. 2013. Toward an integration of cognitive and genetic models of risk for depression. Cogn. Emot. 27:2193–216 [Google Scholar]
  61. Gibb BE, Schofield CA, Coles ME. 2009. Reported history of childhood abuse and young adults’ information-processing biases for facial displays of emotion. Child Maltreat 14:2148–56 https://doi.org/10.1177/1077559508326358 [Google Scholar]
  62. Greenberg BD, Tolliver TJ, Huang S-J, Li Q, Bengel D, Murphy DL. 1999. Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am. J. Med. Genet 88183–87 https://doi.org/10.1002/(SICI)1096-8628(19990205)88:1<83::AID-AJMG15>3.0.CO;2-0 [Google Scholar]
  63. Gulley LD, Oppenheimer CW, Hankin BL. 2014. Associations among negative parenting, attention bias to anger, and social anxiety among youth. Dev. Psychol. 50:2577–85 https://doi.org/10.1037/a0033624 [Google Scholar]
  64. Guyer AE, Kaufman J, Hodgdon HB, Masten CL, Jazbec S. et al. 2006. Behavioral alterations in reward system function: the role of childhood maltreatment and psychopathology. J. Am. Acad. Child Adolesc. Psychiatry 45:91059–67 [Google Scholar]
  65. Hankin BL, Abramson LY, Moffitt TE, Silva PA, McGee R, Angell KE. 1998. Development of depression from preadolescence to young adulthood: emerging gender differences in a 10-year longitudinal study. J. Abnorm. Psychol. 107:1128–40 [Google Scholar]
  66. Hanson JL, Nacewicz BM, Sutterer MJ, Cayo AA, Schaefer SM. et al. 2015. Behavioral problems after early life stress: contributions of the hippocampus and amygdala. Biol. Psychiatry 77:4314–23 https://doi.org/10.1016/j.biopsych.2014.04.020 [Google Scholar]
  67. Hayden EP, Olino TM, Bufferd SJ, Miller A, Dougherty LR. et al. 2013. The serotonin transporter linked polymorphic region and brain-derived neurotrophic factor valine to methionine at position 66 polymorphisms and maternal history of depression: associations with cognitive vulnerability to depression in childhood. Dev. Psychopathol. 25:3587–98 [Google Scholar]
  68. Heils A, Teufel A, Petri S, Stöber G, Riederer P. et al. 2002. Allelic variation of human serotonin transporter gene expression. J. Neurochem. 66:62621–24 https://doi.org/10.1046/j.1471-4159.1996.66062621.x [Google Scholar]
  69. Henry KL, Thornberry TP, Lee RD. 2015. The protective effects of intimate partner relationships on depressive symptomatology among adult parents maltreated as children. J. Adolesc. Health 57:2150–56 https://doi.org/10.1016/j.jadohealth.2015.02.015 [Google Scholar]
  70. Herrenkohl EC, Herrenkohl RC, Egolf B. 1994. Resilient early school-age children from maltreating homes: outcomes in late adolescence. Am. J. Orthopsychiatry 64:301–9 [Google Scholar]
  71. Herrenkohl TI, Klika JB, Brown EC, Herrenkohl RC, Leeb RT. 2013. Tests of the mitigating effects of caring and supportive relationships in the study of abusive disciplining over two generations. J. Adolesc. Health 53:4S18–24 https://doi.org/10.1016/j.jadohealth.2013.04.009 [Google Scholar]
  72. Holz N, Boecker R, Buchmann AF, Blomeyer D, Baumeister S. et al. 2016. Evidence for a sex-dependent MAOA×childhood stress interaction in the neural circuitry of aggression. Cereb. Cortex 26:3904–14 https://doi.org/10.1093/cercor/bhu249 [Google Scholar]
  73. Horan JM, Widom CS. 2015. From childhood maltreatment to allostatic load in adulthood: the role of social support. Child Maltreat 20:4229–39 https://doi.org/10.1177/1077559515597063 [Google Scholar]
  74. Hu X-Z, Lipsky RH, Zhu G, Akhtar LA, Taubman J. et al. 2006. Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am. J. Hum. Genet. 78:5815–26 https://doi.org/10.1086/503850 [Google Scholar]
  75. Jaffee SR. 2017. Child maltreatment and risk for psychopathology. Child and Adolescent Psychopathology TP Beauchaine 144–177 Hoboken, NJ: Wiley, 3rd ed.. [Google Scholar]
  76. Jaffee SR, Bowes L, Ouellet-Morin I, Fisher HL, Moffitt TE. et al. 2013. Safe, stable, nurturing relationships break the intergenerational cycle of abuse: a prospective nationally representative cohort of children in the United Kingdom. J. Adolesc. Health 53:4S4–S10 [Google Scholar]
  77. Jaffee SR, Caspi A, Moffitt TE, Polo-Tomas M, Taylor A. 2007. Individual, family, and neighborhood characteristics promote resilience to physical maltreatment. Child Abus. Negl. 31:231–53 [Google Scholar]
  78. Jaffee SR, Caspi A, Moffitt TE, Taylor A. 2004. Physical maltreatment victim to antisocial child: evidence of an environmentally mediated process. J. Abnorm. Psychol. 113:144–55 [Google Scholar]
  79. Jaffee SR, Gallop R. 2007. Social, emotional, and academic competence among children who have had contact with Child Protective Services: prevalence and stability estimates. J. Am. Acad. Child Adolesc. Psychiatry 46:6757–65 [Google Scholar]
  80. Jaffee SR, Maikovich-Fong AK. 2011. Effects of chronic maltreatment and maltreatment timing on children's behavior and cognitive abilities. J. Child Psychol. Psychiatry 52:2184–94 [Google Scholar]
  81. Jaffee SR, Maikovich-Fong AK. 2013. Child maltreatment and risk for psychopathology. Child and Adolescent Psychopathology. TP Beauchaine, SP Hinshaw 171–96 Hoboken, NJ: Wiley, 2nd ed..
  82. Johnson AL, Gibb BE, McGeary J. 2010. Reports of childhood physical abuse, 5-HTTLPR genotype, and women's attentional biases for angry faces. Cogn. Ther. Res. 34:4380–87 https://doi.org/10.1007/s10608-009-9269-3 [Google Scholar]
  83. Johnson JG, Cohen P, Brown J, Smailes EM, Bernstein DP. 1999. Childhood maltreatment increases risk for personality disorders during early adulthood. Arch. Gen. Psychiatry 56:7600–6 [Google Scholar]
  84. Jonson-Reid M, Presnall N, Drake B, Fox L, Bierut L. et al. 2010. Effects of child maltreatment and inherited liability on antisocial development: an official records study. J. Am. Acad. Child Adolesc. Psychiatry 49:4321–32 [Google Scholar]
  85. Kaplow JB, Widom CS. 2007. Age of onset of child maltreatment predicts long-term mental health outcomes. J. Abnorm. Child Psychol. 116:176–87 [Google Scholar]
  86. Karg K, Burmeister M, Shedden K, Sen S. 2011. The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. Arch. Gen. Psychiatry 68:5444–54 [Google Scholar]
  87. Kaufman J, Cook A, Arny L, Jones B, Pittinsky T. 1994. Problems defining resiliency: illustrations from the study of maltreated children. Dev. Psychopathol. 6:215–29 [Google Scholar]
  88. Kaufman J, Yang B-Z, Douglas-Palumberi H, Crouse-Artus M, Lipschitz D. et al. 2007. Genetic and environmental predictors of early alcohol use. Biol. Psychiatry 61:111228–34 https://doi.org/10.1016/j.biopsych.2006.06.039 [Google Scholar]
  89. Kay CL, Green JM. 2016. Social cognitive deficits and biases in maltreated adolescents in UK out-of-home care: relation to disinhibited attachment disorder and psychopathology. Dev. Psychopathol. 28:173–83 https://doi.org/10.1017/S0954579415000292 [Google Scholar]
  90. Keil V, Price JM. 2009. Social information-processing patterns of maltreated children in two social domains. J. Appl. Dev. Psychol. 30:143–52 https://doi.org/10.1016/j.appdev.2008.10.003 [Google Scholar]
  91. Kelly PA, Viding E, Puetz VB, Palmer AL, Mechelli A. et al. 2015. Sex differences in socioemotional functioning, attentional bias, and gray matter volume in maltreated children: a multilevel investigation. Dev. Psychopathol. 27:4 Part 21591–609 https://doi.org/10.1017/S0954579415000966 [Google Scholar]
  92. Kim J, Cicchetti D. 2009. Longitudinal pathways linking child maltreatment, emotion regulation, peer relations, and psychopathology: pathways linking maltreatment, emotion regulation, and psychopathology. J. Child Psychol. Psychiatry 51:6706–16 https://doi.org/10.1111/j.1469-7610.2009.02202.x [Google Scholar]
  93. Klimes-Dougan B, Kistner J. 1990. Physically abused preschoolers’ responses to peers’ distress. Dev. Psychol. 26:4599–602 https://doi.org/10.1037/0012-1649.26.4.599 [Google Scholar]
  94. Lamis DA, Wilson CK, King NM, Kaslow NJ. 2014. Child abuse, social support, and social functioning in African American children. J. Fam. Violence 29:8881–91 https://doi.org/10.1007/s10896-014-9639-9 [Google Scholar]
  95. Lansford JE, Dodge KA, Pettit GS, Bates JE. 2010. Does physical abuse in early childhood predict substance use in adolescence and early adulthood?. Child Maltreat 15:2190–94 [Google Scholar]
  96. Lansford JE, Dodge KA, Pettit GS, Bates JE, Crozier J, Kaplow J. 2002. Long-term effects of early child physical maltreatment on psychological, behavioral, and academic problems in adolescence: a 12-year prospective study. Arch. Pediatr. Adolesc. Med. 156:8824–30 [Google Scholar]
  97. Lansford JE, Miller-Johnson S, Berlin LJ, Dodge KA, Bates JE, Pettit GS. 2007. Early physical abuse and later violent delinquency: a prospective longitudinal study. Child Maltreat 12:3233–45 [Google Scholar]
  98. Lee B-T, Ham B-J. 2008. Monoamine oxidase A–uVNTR genotype affects limbic brain activity in response to affective facial stimuli. NeuroReport 19:5515–19 https://doi.org/10.1097/WNR.0b013e3282f94294 [Google Scholar]
  99. Leeb RT, Paulozzi L, Melanson C, Simon T, Arias I. 2008. Child Maltreatment Surveillance: Uniform Definitions for Public Health and Recommended Data Elements Version 1. 0 Atlanta, GA: Cent. Dis. Control Prev., Natl. Cent. Inj. Prev. Control
  100. Lesch KP, Bengel D, Heils A, Sabol S, Greenberg B. et al. 1996. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527–31 [Google Scholar]
  101. Li M, D'Arcy C, Meng X. 2016. Maltreatment in childhood substantially increases the risk of adult depression and anxiety in prospective cohort studies: systematic review, meta-analysis, and proportional attributable fractions. Psychol. Med. 46:4717–30 https://doi.org/10.1017/S0033291715002743 [Google Scholar]
  102. Lucki I. 1998. The spectrum of behaviors influenced by serotonin. Biol. Psychiatry 44:151–62 [Google Scholar]
  103. Luke N, Banerjee R. 2013. Differentiated associations between childhood maltreatment experiences and social understanding: a meta-analysis and systematic review. Dev. Rev. 33:11–28 https://doi.org/10.1016/j.dr.2012.10.001 [Google Scholar]
  104. Luntz BK, Widom CS. 1994. Antisocial personality disorder in abused and neglected children grown up. Am. J. Psychiatry 151:5670–74 [Google Scholar]
  105. Manly JT, Kim JE, Rogosch FA, Cicchetti D. 2001. Dimensions of child maltreatment and children's adjustment: contributions of developmental timing and subtype. Dev. Psychopathol. 13:759–82 [Google Scholar]
  106. Masten CL, Guyer AE, Hodgdon HB, McClure EB, Charney DS. et al. 2008. Recognition of facial emotions among maltreated children with high rates of post-traumatic stress disorder. Child Abus. Negl. 32:1139–53 https://doi.org/10.1016/j.chiabu.2007.09.006 [Google Scholar]
  107. Maxfield MG, Widom CS. 1996. The cycle of violence—revisited 6 years later. Arch. Pediatr. Adolesc. Med. 150:4390–95 [Google Scholar]
  108. McCrory EJ, De Brito SA, Kelly PA, Bird G, Sebastian CL. et al. 2013. Amygdala activation in maltreated children during pre-attentive emotional processing. Br. J. Psychiatry 202:4269–76 https://doi.org/10.1192/bjp.bp.112.116624 [Google Scholar]
  109. McCrory E, De Brito SA, Sebastian CL, Mechelli A, Bird G. et al. 2011. Heightened neural reactivity to threat in child victims of family violence. Curr. Biol. 21:23R947–48 [Google Scholar]
  110. McGloin JM, Widom CS. 2001. Resilience among abused and neglected children grown up. Dev. Psychopathol. 13:1021–38 [Google Scholar]
  111. McLaughlin KA, Peverill M, Gold AL, Alves S, Sheridan MA. 2015. Child maltreatment and neural systems underlying emotion regulation. J. Am. Acad. Child Adolesc. Psychiatry 54:9753–62 https://doi.org/10.1016/j.jaac.2015.06.010 [Google Scholar]
  112. Mehta MA, Gore-Langton E, Golembo N, Colvert E, Williams SCR, Sonuga-Barke E. 2010. Hyporesponsive reward anticipation in the basal ganglia following severe institutional deprivation early in life. J. Cogn. Neurosci. 22:102316–25 [Google Scholar]
  113. Mersky JP, Berger LM, Reynolds AJ, Gromoske AN. 2009. Risk factors for child and adolescent maltreatment: a longitudinal investigation of a cohort of inner-city youth. Child Maltreat 14:173–88 https://doi.org/10.1177/1077559508318399 [Google Scholar]
  114. Meyer-Lindenberg A, Buckholtz JW, Kolachana B, Hariri AR, Pezawas L. et al. 2006. Neural mechanisms of genetic risk for impulsivity and violence in humans. PNAS 103:166269–74 [Google Scholar]
  115. Miller AL, Gouley KK, Seifer R, Zakriski A, Eguia M, Vergnani M. 2005. Emotion knowledge skills in low-income elementary school children: associations with social status and peer experiences. Soc. Dev. 14:4637–51 https://doi.org/10.1111/j.1467-9507.2005.00321.x [Google Scholar]
  116. Miller R, Wankerl M, Stalder T, Kirschbaum C, Alexander N. 2013. The serotonin transporter gene-linked polymorphic region (5-HTTLPR) and cortisol stress reactivity: a meta-analysis. Mol. Psychiatry 18:91018–24 [Google Scholar]
  117. Milot T, Ethier LS, St-Laurent D, Provost MA. 2010. The role of trauma symptoms in the development of behavioral problems in maltreated preschoolers. Child Abus. Negl. 34:4225–34 [Google Scholar]
  118. Miu AC, Vulturar R, Chis A, Ungureanu L, Gross JJ. 2013. Reappraisal as a mediator in the link between 5-HTTLPR and social anxiety symptoms. Emotion 13:61012–22 [Google Scholar]
  119. Moran PB, Eckenrode J. 1992. Protective personality characteristics among adolescent victims of maltreatment. Child Abus. Negl. 16:743–54 [Google Scholar]
  120. Moylan CA, Herrenkohl TI, Sousa C, Tajima EA, Herrenkohl RC, Russo MJ. 2010. The effects of child abuse and exposure to domestic violence on adolescent internalizing and externalizing behavior problems. J. Fam. Violence 25:153–63 [Google Scholar]
  121. Mueller A, Armbruster D, Moser DA, Canli T, Lesch KP. et al. 2011. Interaction of serotonin transporter gene-linked polymorphic region and stressful life events predicts cortisol stress response. Neuropsychopharmacology 36:71332–39 [Google Scholar]
  122. Munafo MR, Brown SM, Hariri AR. 2008. Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. Biol. Psychiatry 63:9852–57 [Google Scholar]
  123. Munafo MR, Durrant C, Lewis G, Flint J. 2009. Gene×environment interactions at the serotonin transporter locus. Biol. Psychiatry 65:3211–19 [Google Scholar]
  124. Nikulina V, Widom CS, Czaja S. 2011. The role of childhood neglect and childhood poverty in predicting mental health, academic achievement and crime in adulthood. Am. J. Community Psychol. 48:3–4309–21 https://doi.org/10.1007/s10464-010-9385-y [Google Scholar]
  125. Noll JG, Trickett PK, Harris WW, Putnam FW. 2009. The cumulative burden borne by offspring whose mothers were sexually abused as children: descriptive results from a multigenerational study. J. Interpers. Violence 24:424–49 [Google Scholar]
  126. Passamonti L, Fera F, Magariello A, Cerasa A, Gioia MC. et al. 2006. Monoamine oxidase-A genetic variations influence brain activity associated with inhibitory control: new insight into the neural correlates of impulsivity. Biol. Psychiatry 59:4334–40 [Google Scholar]
  127. Pears K, Fisher PA. 2005. Developmental, cognitive, and neuropsychological functioning in preschool-aged foster children: associations with prior maltreatment and placement history. Dev. Behav. Pediatr. 26:2112–22 [Google Scholar]
  128. Pechtel P, Pizzagalli DA. 2013. Disrupted reinforcement learning and maladaptive behavior in women with a history of childhood sexual abuse: a high-density event-related potential study. JAMA Psychiatry 70:5499–507 https://doi.org/10.1001/jamapsychiatry.2013.728 [Google Scholar]
  129. Pergamin-Hight L, Bakermans-Kranenburg MJ, van IJzendoorn MH, Bar-Haim Y. 2012. Variations in the promoter region of the serotonin transporter gene and biased attention for emotional information: a meta-analysis. Biol. Psychiatry 71:4373–79 https://doi.org/10.1016/j.biopsych.2011.10.030 [Google Scholar]
  130. Perlman SB, Kalish CW, Pollak SD. 2008. The role of maltreatment experience in children's understanding of the antecedents of emotion. Cogn. Emot. 22:4651–70 [Google Scholar]
  131. Pine DS, Mogg K, Bradley BP, Montgomery L, Monk CS. et al. 2005. Attention bias to threat in maltreated children: implications for vulnerability to stress-related psychopathology. Am. J. Psychiatry 162:2291–96 [Google Scholar]
  132. Pollak SD. 2003. Experience-dependent affective learning and risk for psychopathology in children. Ann. N. Y. Acad. Sci. 1008:1102–11 https://doi.org/10.1196/annals.1301.011 [Google Scholar]
  133. Pollak SD, Cicchetti D, Hornung K, Reed A. 2000. Recognizing emotion in faces: developmental effects of child abuse and neglect. Dev. Psychol. 36:679–88 [Google Scholar]
  134. Pollak SD, Kistler DJ. 2002. Early experience is associated with the development of categorical representations for facial expressions of emotion. PNAS 99:139072–76 https://doi.org/10.1073/pnas.142165999 [Google Scholar]
  135. Pollak SD, Klorman R, Thatcher JE, Cicchetti D. 2001. P3b reflects maltreated children's reactions to facial displays of emotion. Psychophysiology 38:2267–74 [Google Scholar]
  136. Pollak SD, Messner M, Kistler DJ, Cohn JF. 2009. Development of perceptual expertise in emotion recognition. Cognition 110:2242–47 https://doi.org/10.1016/j.cognition.2008.10.010 [Google Scholar]
  137. Pollak SD, Sinha P. 2002. Effects of early experience on children's recognition of facial displays of emotion. Dev. Psychol. 38:5784–91 [Google Scholar]
  138. Pollak SD, Tolley-Schell SA. 2003. Selective attention to facial emotion in physically abused children. J. Abnorm. Psychol. 112:3323–38 [Google Scholar]
  139. Powers A, Ressler KJ, Bradley RG. 2009. The protective role of friendship on the effects of childhood abuse and depression. Depress. Anxiety 26:146–53 https://doi.org/10.1002/da.20534 [Google Scholar]
  140. Putnam FW, Helmers K, Horowitz LA. 1995. Hypnotizability and dissociativity in sexually abused girls. Child Abus. Negl. 19:5645–55 [Google Scholar]
  141. Risch N, Herrell R, Lehner T, Liang KY, Eaves L. et al. 2009. Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA 301:232462–71 [Google Scholar]
  142. Rogosch FA, Oshri A, Cicchetti D. 2010. From child maltreatment to adolescent cannabis abuse and dependence: a developmental cascade model. Dev. Psychopathol. 22:4883–97 https://doi.org/10.1017/S0954579410000520 [Google Scholar]
  143. Runtz MG, Schallow JR. 1997. Social support and coping strategies as mediators of adult adjustment following childhood maltreatment. Child Abus. Negl. 21:2211–26 https://doi.org/10.1016/S0145-2134(96)00147-0 [Google Scholar]
  144. Sabol S, Hu S, Hamer D. 1998. A functional polymorphism in the monoamine oxidase A gene promoter. Hum. Genet. 103:273–79 [Google Scholar]
  145. Salazar AM, Keller TE, Courtney ME. 2011. Understanding social support's role in the relationship between maltreatment and depression in youth with foster care experience. Child Maltreat 16:2102–13 [Google Scholar]
  146. Schofield TJ, Lee RD, Merrick MT. 2013. Safe, stable, nurturing relationships as a moderator of intergenerational continuity of child maltreatment: a meta-analysis. J. Adolesc. Health 53:4S32–38 https://doi.org/10.1016/j.jadohealth.2013.05.004 [Google Scholar]
  147. Schumm JA, Briggs-Phillips M, Hobfoll SE. 2006. Cumulative interpersonal traumas and social support as risk and resiliency factors in predicting PTSD and depression among inner-city women. J. Trauma. Stress 19:6825–36 https://doi.org/10.1002/jts.20159 [Google Scholar]
  148. Scott KM, Smith DR, Ellis PM. 2010. Prospectively ascertained child maltreatment and its association with DSM-IV mental disorders in young adults. Arch. Gen. Psychiatry 67:7712–19 [Google Scholar]
  149. Sedlak AJ, Mettenburg J, Basena M, Petta I, McPherson K. et al. 2010. Fourth national incidence study of child abuse and neglect (NIS–4): Report to Congress, Executive Summary Washington, DC: US Dept. Health Hum. Serv., Adm. Child. Fam.
  150. Shackman JE, Fatani S, Camras LA, Berkowitz MJ, Bachorowski JA, Pollak SD. 2010. Emotion expression among abusive mothers is associated with their children's emotion processing and problem behaviours. Cogn. Emot. 24:81421–30 [Google Scholar]
  151. Shackman JE, Pollak SD. 2014. Impact of physical maltreatment on the regulation of negative affect and aggression. Dev. Psychopathol. 26:4 Part 11021–33 https://doi.org/10.1017/S0954579414000546 [Google Scholar]
  152. Shackman JE, Shackman AJ, Pollak SD. 2007. Physical abuse amplifies attention to threat and increases anxiety in children. Emotion 7:4838–52 [Google Scholar]
  153. Shenk CE, Putnam FW, Noll JG. 2013. Predicting the accuracy of facial affect recognition: the interaction of child maltreatment and intellectual functioning. J. Exp. Child Psychol. 114:2229–42 https://doi.org/10.1016/j.jecp.2012.08.007 [Google Scholar]
  154. Shipman KL, Schneider R, Fitzgerald MM, Sims C, Swisher L, Edwards A. 2007. Maternal emotion socialization in maltreating and non-maltreating families: implications for children's emotion regulation. Soc. Dev. 16:2268–85 https://doi.org/10.1111/j.1467-9507.2007.00384.x [Google Scholar]
  155. Spaccarelli S, Kim S. 1995. Resilience criteria and factors associated with resilience in sexually abused girls. Child Abus. Negl. 19:91171–82 https://doi.org/10.1016/0145-2134(95)00077-L [Google Scholar]
  156. Sperry DM, Widom CS. 2013. Child abuse and neglect, social support, and psychopathology in adulthood: a prospective investigation. Child Abus. Negl. 37:6415–25 https://doi.org/10.1016/j.chiabu.2013.02.006 [Google Scholar]
  157. Stouthamer-Loeber M, Loeber R, Homish DL, Wei E. 2001. Maltreatment of boys and the development of disruptive and delinquent behavior. Dev. Psychopathol. 13:941–55 [Google Scholar]
  158. Szily E, Bowen J, Unoka Z, Simon L, Keri S. 2008. Emotion appraisal is modulated by the genetic polymorphism of the serotonin transporter. J. Neural Transm. 115:6819–22 [Google Scholar]
  159. Teisl M, Cicchetti D. 2008. Physical abuse, cognitive and emotional processes, and aggressive/disruptive behavior problems. Soc. Dev. 17:11–23 https://doi.org/10.1111/j.1467-9507.2007.00412.x [Google Scholar]
  160. Thornberry TP, Henry KL, Ireland TO, Smith CA. 2010. The causal impact of childhood-limited maltreatment and adolescent maltreatment on early adult adjustment. J. Adolesc. Health 46:4359–65 [Google Scholar]
  161. Thornberry TP, Henry KL, Smith CA, Ireland TO, Greenman SJ, Lee RD. 2013. Breaking the cycle of maltreatment: the role of safe, stable, and nurturing relationships. J. Adolesc. Health 53:4S25–31 https://doi.org/10.1016/j.jadohealth.2013.04.019 [Google Scholar]
  162. Thornberry TP, Matsuda M, Greenman SJ, Augustyn MB, Henry KL. et al. 2014. Adolescent risk factors for child maltreatment. Child Abus. Negl. 38:4706–22 https://doi.org/10.1016/j.chiabu.2013.08.009 [Google Scholar]
  163. Tottenham N, Hare TA, Millner A, Gilhooly T, Zevin JD, Casey BJ. 2011. Elevated amygdala response to faces following early deprivation. Dev. Sci. 14:2190–204 https://doi.org/10.1111/j.1467-7687.2010.00971.x [Google Scholar]
  164. Tremblay C, Hébert M, Piché C. 1999. Coping strategies and social support as mediators of consequences in child sexual abuse victims. Child Abus. Negl. 23:9929–45 https://doi.org/10.1016/S0145-2134(99)00056-3 [Google Scholar]
  165. Troller-Renfree S, McDermott JM, Nelson CA, Zeanah CH, Fox NA. 2015. The effects of early foster care intervention on attention biases in previously institutionalized children in Romania. Dev. Sci. 18:5713–22 https://doi.org/10.1111/desc.12261 [Google Scholar]
  166. US Dep. Health Hum. Serv., Adm. Child. Fam., ACF (Adm. Child. Youth Fam.), Child. Bur. 2016. Child Maltreatment 2014 Washington, DC: US Dep. Health Hum. Serv http://www.acf.hhs.gov/programs/cb/research-data-technology/statistics-research/child-maltreatment
  167. van Harmelen A-L, van Tol M-J, Demenescu LR, van der Wee NJA, Veltman DJ. et al. 2013. Enhanced amygdala reactivity to emotional faces in adults reporting childhood emotional maltreatment. Soc. Cogn. Affect. Neurosci. 8:4362–69 https://doi.org/10.1093/scan/nss007 [Google Scholar]
  168. Varese F, Smeets F, Drukker M, Lieverse R, Lataster T. et al. 2012. Childhood adversities increase the risk of psychosis: a meta-analysis of patient-control, prospective- and cross-sectional cohort studies. Schizophr. Bull. 38:4661–71 https://doi.org/10.1093/schbul/sbs050 [Google Scholar]
  169. Vranceanu A-M, Hobfoll SE, Johnson RJ. 2007. Child multi-type maltreatment and associated depression and PTSD symptoms: the role of social support and stress. Child Abus. Negl. 31:171–84 https://doi.org/10.1016/j.chiabu.2006.04.010 [Google Scholar]
  170. Wagner MF, Milner JS, McCarthy RJ, Crouch JL, McCanne TR, Skowronski JJ. 2015. Facial emotion recognition accuracy and child physical abuse: an experiment and a meta-analysis. Psychol. Violence 5:2154–62 https://doi.org/10.1037/a0036014 [Google Scholar]
  171. Wankerl M, Miller R, Kirschbaum C, Hennig J, Stalder T, Alexander N. 2014. Effects of genetic and early environmental risk factors for depression on serotonin transporter expression and methylation profiles. Transl. Psychiatry 4:6e402 https://doi.org/10.1038/tp.2014.37 [Google Scholar]
  172. Widom C. 1989a. Does violence beget violence? A critical examination of the literature. Psychol. Bull. 106:13–28 https://doi.org/10.1037/0033-2909.115.2.287 [Google Scholar]
  173. Widom C. 1989b. The cycle of violence. Science 244:4901160–66 [Google Scholar]
  174. Widom C. 1999. Posttraumatic stress disorder in abused and neglected children grown up. Am. J. Psychiatry 156:81223–29 https://doi.org/10.1176/ajp.156.8.1223 [Google Scholar]
  175. Widom C, Czaja SJ, Paris J. 2009. A prospective investigation of borderline personality disorder in abused and neglected children followed up into adulthood. J. Pers. Disord. 23:5433–46 [Google Scholar]
  176. Widom C, DuMont K, Czaja S. 2007. A prospective investigation of major depressive disorder and comorbidity in abused and neglected children grown up. Arch. Gen. Psychiatry 64:149–56 https://doi.org/10.1001/archpsyc.64.1.49 [Google Scholar]
  177. Widom C, Ireland T, Glynn PJ. 1995. Alcohol abuse in abused and neglected children followed-up: Are they at increased risk?. J. Stud. Alcohol 56:2207–17 https://doi.org/10.15288/jsa.1995.56.207 [Google Scholar]
  178. Widom C, Marmorstein NR, Raskin White H. 2006. Childhood victimization and illicit drug use in middle adulthood. Psychol. Addict. Behav. 20:4394–403 https://doi.org/10.1037/0893-164X.20.4.394 [Google Scholar]
  179. Widom CS, Czaja S. 2012. Childhood trauma, psychopathology, and violence: disentangling causes, consequences, and correlates. Trauma, Psychopathology, and Violence: Causes, Consequences, or Correlates? ed. CS Widom 291–317 Oxford, UK: Oxford Univ. Press [Google Scholar]
  180. Widom CS, Czaja SJ, DuMont KA. 2015. Intergenerational transmission of child abuse and neglect: real or detection bias?. Science 347:62291480–85 https://doi.org/10.1126/science.1259917 [Google Scholar]
  181. Widom CS, Morris S. 1997. Accuracy of adult recollections of childhood victimization, part 2: childhood sexual abuse. Psychol. Assess. 9:134–46 https://doi.org/10.1037/1040-3590.9.1.34 [Google Scholar]
  182. Widom CS, Weiler BL, Cottler LB. 1999. Childhood victimization and drug abuse: a comparison of prospective and retrospective findings. J. Consult. Clin. Psychol. 67:6867–80 https://doi.org/10.1037/0022-006X.67.6.867 [Google Scholar]
  183. Wilhelm K, Siegel JE, Finch AW, Hadzi-Pavlovic D, Mitchell PB. et al. 2007. The long and short of it: associations between 5-HTT genotypes and coping with stress. Psychosom. Med. 69:7614–20 https://doi.org/10.1097/PSY/.0b013e31814cec64 [Google Scholar]
  184. Williams JH, Van Dorn RA, Bright CL, Jonson-Reid M, Nebbitt VE. 2010. Child maltreatment and delinquency onset among African American adolescent males. Res. Soc. Work Pract. 20:3253–59 [Google Scholar]
  185. Williams LM, Gatt JM, Schofield PR, Olivieri G, Peduto A, Gordon E. 2009. “Negativity bias” in risk for depression and anxiety: brain–body fear circuitry correlates, 5-HTTLPR and early life stress. NeuroImage 47:3804–14 https://doi.org/10.1016/j.neuroimage.2009.05.009 [Google Scholar]
  186. Yates TM, Carlson EA, Egeland B. 2008. A prospective study of child maltreatment and self-injurious behavior in a community sample. Dev. Psychopathol. 20:2651–71 https://doi.org/10.1017/S0954579408000321 [Google Scholar]
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