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Annual Review of Food Science and Technology

Volume 16, 2025

The Role of Ginseng and Its Bioactive Compounds in Aging: Cells and Animal Studies

  • Da-Yeon Lee1, Nicole Noren Hooten2, Jennifer F. O'Connell3, Boo-Yong Lee4,** and Yoo Kim1,**
  • 1Department of Nutritional Sciences, Oklahoma State University, Stillwater, Oklahoma, USA; email: [email protected] 2Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Baltimore, Maryland, USA 3Center for Scientific Review, National Institutes of Health, Bethesda, Maryland, USA 4Department of Food Science and Biotechnology, College of Life Science, CHA University, Seongnam-si, Gyeonggi-do, Republic of Korea; email: [email protected]
    ** *Co-corresponding authors: Boo-Yong Lee and Yoo Kim contributed equally to this article.
  • Vol. 16:333-354 (Volume publication date April 2025)
  • First published as a Review in Advance on February 19, 2025
  •  
    This work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See credit lines of images or other third-party material in this article for license information.

Abstract

Aging is an inevitable process that is characterized by physiological deterioration and increased vulnerability to stressors. Therefore, the interest in hallmarks, mechanisms, and ways to delay or prevent aging has grown for decades. Natural plant products and their bioactive compounds have been studied as a promising strategy to overcome aging. Ginseng, a traditional herbal medicine, and its bioactive compound, the ginsenosides, have increasingly gained attention because of various pharmacological functions. This review introduces the species, useful parts, characteristics, and active components of ginseng. It primarily focuses on the bioconversion of ginsenosides through the unique steaming and drying process. More importantly, this review enumerates the antiaging mechanisms of ginseng, ginsenosides, and other bioactive compounds, highlighting their potential to extend the health span and mitigate age-related diseases based on twelve representative hallmarks of aging.

Keyword(s): aging, ginseng, ginsenoside, senolytics, senomorphics
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2025-04-28
2025-06-13
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The Role of Ginseng and Its Bioactive Compounds in Aging: Cells and Animal Studies
Annual Review of Food Science and Technology 16, 333 (2025); https://doi.org/10.1146/annurev-food-111523-121753
/content/journals/10.1146/annurev-food-111523-121753
/content/journals/10.1146/annurev-food-111523-121753
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