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Annual Review of Microbiology

Volume 78, 2024

Cyclic Diguanylate in the Wild: Roles During Plant and Animal Colonization

Abstract

Cyclic diguanylate (c-di-GMP) is a near-ubiquitous signaling molecule that regulates the motility-to-sessility transition in many bacterial species. Among the phenotypes influenced by c-di-GMP are biofilm formation, motility, cell cycle, and virulence. The hallmark phenotypes regulated by c-di-GMP—biofilm formation and motility—are key determinants of host–bacterial interactions. A large body of research has identified the roles of c-di-GMP in regulating phenotypes in culture. While numerous studies have investigated roles for c-di-GMP during the establishment and maintenance of pathogenic host–bacterial associations, considerably less attention has been devoted to defining the roles of c-di-GMP during beneficial and commensal associations. This review describes the known roles of c-di-GMP in regulating phenotypes that contribute to host colonization, with a focus on knowledge gaps and future prospects for examining c-di-GMP during beneficial colonization.

Keyword(s): bacterial behavior, biofilm, host colonization, motility, second messenger, signal transduction
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/content/journals/10.1146/annurev-micro-041522-101729
2024-11-20
2025-04-22
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Cyclic Diguanylate in the Wild: Roles During Plant and Animal Colonization
Annual Review of Microbiology 78, 533 (2024); https://doi.org/10.1146/annurev-micro-041522-101729
/content/journals/10.1146/annurev-micro-041522-101729
/content/journals/10.1146/annurev-micro-041522-101729
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