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Annual Review of Microbiology

Volume 71, 2017

Germination of Spores of the Orders and

Abstract

Dormant and spores begin to grow when small molecules (germinants) trigger germination, potentially leading to food spoilage or disease. Germination-specific proteins sense germinants, transport small molecules, and hydrolyze specific bonds in cortex peptidoglycan and specific proteins. Major events in germination include () germinant sensing; () commitment to germinate; () release of spores’ depot of dipicolinic acid (DPA); () hydrolysis of spores’ peptidoglycan cortex; and () spore core swelling and water uptake, cell wall peptidoglycan remodeling, and restoration of core protein and inner spore membrane lipid mobility. Germination is similar between and , but some species differ in how germinants are sensed and how cortex hydrolysis and DPA release are triggered. Despite detailed knowledge of the proteins and signal transduction pathways involved in germination, precisely what some germination proteins do and how they do it remain unclear.

Keyword(s): Bacillus, Clostridiodes difficile, Clostridium, cortex hydrolysis, dipicolinic acid, germination, spores
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2017-09-08
2025-02-11
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Germination of Spores of the Orders Bacillales and Clostridiales
Annual Review of Microbiology 71, 459 (2017); https://doi.org/10.1146/annurev-micro-090816-093558
/content/journals/10.1146/annurev-micro-090816-093558
/content/journals/10.1146/annurev-micro-090816-093558
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  • Article Type: Review Article

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