PT - Journal Article
AU - Watabe-Uchida, Mitsuko
AU - Eshel, Neir
AU - Uchida, Naoshige
DP - 2017
TI - Neural Circuitry of Reward Prediction Error
TA - Annual Review of Neuroscience,
VI - 40
IP - Volume 40, 2017
PG - 373-394
AID - 10.1146/annurev-neuro-072116-031109
SO - Annual Review of Neuroscience 2017;40(1):373-394
AB - Dopamine neurons facilitate learning by calculating reward prediction error, or the difference between expected and actual reward. Despite two decades of research, it remains unclear how dopamine neurons make this calculation. Here we review studies that tackle this problem from a diverse set of approaches, from anatomy to electrophysiology to computational modeling and behavior. Several patterns emerge from this synthesis: that dopamine neurons themselves calculate reward prediction error, rather than inherit it passively from upstream regions; that they combine multiple separate and redundant inputs, which are themselves interconnected in a dense recurrent network; and that despite the complexity of inputs, the output from dopamine neurons is remarkably homogeneous and robust. The more we study this simple arithmetic computation, the knottier it appears to be, suggesting a daunting (but stimulating) path ahead for neuroscience more generally.,
4099- https://www.annualreviews.org
4100- https://www.annualreviews.org/content/journals/10.1146/annurev-neuro-072116-031109