RT Journal Article
SR Electronic(1)
A1 Watabe-Uchida, Mitsuko
A1 Eshel, Neir
A1 Uchida, NaoshigeYR 2017
T1 Neural Circuitry of Reward Prediction Error
JF Annual Review of Neuroscience,
VO 40
IS Volume 40, 2017
SP 373
OP 394
DO https://doi.org/10.1146/annurev-neuro-072116-031109
PB Annual Reviews,
SN 1545-4126,
AB Dopamine neurons facilitate learning by calculating reward prediction error, or the difference between expected and actual reward. Despite two decades of research, it remains unclear how dopamine neurons make this calculation. Here we review studies that tackle this problem from a diverse set of approaches, from anatomy to electrophysiology to computational modeling and behavior. Several patterns emerge from this synthesis: that dopamine neurons themselves calculate reward prediction error, rather than inherit it passively from upstream regions; that they combine multiple separate and redundant inputs, which are themselves interconnected in a dense recurrent network; and that despite the complexity of inputs, the output from dopamine neurons is remarkably homogeneous and robust. The more we study this simple arithmetic computation, the knottier it appears to be, suggesting a daunting (but stimulating) path ahead for neuroscience more generally.,
UL https://www.annualreviews.org/content/journals/10.1146/annurev-neuro-072116-031109