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Annual Review of Public Health

Volume 46, 2025

State of the Science of Structural Stigma and LGBTQ+ Health: Meta-Analytic Evidence, Research Gaps, and Future Directions

  • Micah R. Lattanner1, Sarah McKetta2, John E. Pachankis3 and Mark L. Hatzenbuehler4
  • 1Department of Public Health Santa Clara University, Santa Clara, California, USA 2Department of Population Medicine, Harvard Medical School, Harvard University, Boston, Massachusetts, USA 3Department of Social and Behavioral Sciences, School of Public Health, Yale University, New Haven, Connecticut, USA 4Department of Psychology, Harvard University, Cambridge, Massachusetts, USA; email: [email protected]
  • Vol. 46:213-231 (Volume publication date April 2025)
  • First published as a Review in Advance on November 12, 2024
  • Copyright © 2025 by the author(s).
    This work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See credit lines of images or other third-party material in this article for license information.

Abstract

While public health practitioners and scholars have long theorized that structural forms of stigma shape the health of disadvantaged groups, they have frequently bemoaned the lack of research on this topic. A unique opportunity to address this lacuna occurred in the past two decades, with the advent of dramatic changes in laws, social attitudes, and other structural manifestations of stigma surrounding LGBTQ+ individuals. In a review of this literature, we conducted a meta-analysis of LGBTQ+ structural stigma and health, finding an effect size comparable to several other well-established macrolevel risk factors for poor health (e.g., income inequality, racial residential segregation, neighborhood socioeconomic status). In addition, we enumerated a range of established methodological strategies that studies have used to strengthen inferences; these strategies include documenting result specificity (i.e., structural stigma is unrelated to the health of cisgender heterosexuals), addressing alternative explanations (e.g., social selection), and triangulating evidence across multiple methods, measures, and health outcomes. We offer suggestions for future research to advance this rapidly expanding field, including identifying sources of unexplained heterogeneity in the structural stigma–health association. Finally, we discuss implications for other marginalized groups and for public health interventions and policies to reduce LGBTQ+ health disparities.

Keyword(s): discrimination, LGBTQ+, meta-analysis, policy, prejudice
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2025-04-04
2025-06-23
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State of the Science of Structural Stigma and LGBTQ+ Health: Meta-Analytic Evidence, Research Gaps, and Future Directions
Annual Review of Public Health 46, 213 (2025); https://doi.org/10.1146/annurev-publhealth-071723-013336
/content/journals/10.1146/annurev-publhealth-071723-013336
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