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Annual Review of Statistics and Its Application

Volume 12, 2025

Causal Mediation Analysis for Integrating Exposure, Genomic, and Phenotype Data

Abstract

Causal mediation analysis provides an attractive framework for integrating diverse types of exposure, genomic, and phenotype data. Recently, this field has seen a surge of interest, largely driven by the increasing need for causal mediation analyses in health and social sciences. This article aims to provide a review of recent developments in mediation analysis, encompassing mediation analysis of a single mediator and a large number of mediators, as well as mediation analysis with multiple exposures and mediators. Our review focuses on the recent advancements in statistical inference for causal mediation analysis, especially in the context of high-dimensional mediation analysis. We delve into the complexities of testing mediation effects, especially addressing the challenge of testing a large number of composite null hypotheses. Through extensive simulation studies, we compare the existing methods across a range of scenarios. We also include an analysis of data from the Normative Aging Study, which examines DNA methylation CpG sites as potential mediators of the effect of smoking status on lung function. We discuss the pros and cons of these methods and future research directions.

Keyword(s): causal inference, composite null hypothesis, false discovery rate, large-scale mediation analysis, multiple exposures, multiple testing
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2025-03-07
2025-04-22
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Causal Mediation Analysis for Integrating Exposure, Genomic, and Phenotype Data
Annual Review of Statistics and Its Application 12, 337 (2025); https://doi.org/10.1146/annurev-statistics-040622-031653
/content/journals/10.1146/annurev-statistics-040622-031653
/content/journals/10.1146/annurev-statistics-040622-031653
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