1932

Abstract

In medical studies, time-to-event outcomes such as time to death or relapse of a disease are routinely recorded along with longitudinal data that are observed intermittently during the follow-up period. For various reasons, marginal approaches to model the event time, corresponding to separate approaches for survival data/longitudinal data, tend to induce bias and lose efficiency. Instead, a joint modeling approach that brings the two types of data together can reduce or eliminate the bias and yield a more efficient estimation procedure. A well-established avenue for joint modeling is the joint likelihood approach that often produces semiparametric efficient estimators for the finite-dimensional parameter vectors in both models. Through a transformation survival model with an unspecified baseline hazard function, this review introduces joint modeling that accommodates both baseline covariates and time-varying covariates. The focus is on the major challenges faced by joint modeling and how they can be overcome. A review of available software implementations and a brief discussion of future directions of the field are also included.

Loading

Article metrics loading...

/content/journals/10.1146/annurev-statistics-112723-034334
2024-11-14
2024-12-09
Loading full text...

Full text loading...

/content/journals/10.1146/annurev-statistics-112723-034334
Loading
  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error