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Annual Review of Virology

Volume 11, 2024

A Hitchhiker's Guide Through the Cell: The World According to the Capsids of Alphaherpesviruses

Abstract

The nucleoplasm, the cytosol, the inside of virions, and again the cytosol comprise the world in which the capsids of alphaherpesviruses encounter viral and host proteins that support or limit them in performing their tasks. Here, we review the fascinating conundrum of how specific protein-protein interactions late in alphaherpesvirus infection orchestrate capsid nuclear assembly, nuclear egress, and cytoplasmic envelopment, but target incoming capsids to the nuclear pores in naive cells to inject the viral genomes into the nucleoplasm for viral transcription and replication. Multiple capsid interactions with viral and host proteins have been characterized using viral mutants and assays that reconstitute key stages of the infection cycle. Keratinocytes, fibroblasts, mucosal epithelial cells, neurons, and immune cells employ cell type–specific intrinsic and cytokine-induced resistance mechanisms to restrict several stages of the viral infection cycle. However, concomitantly, alphaherpesviruses have evolved countermeasures to ensure efficient capsid function during infection.

Keyword(s): assembly, capsid, herpesvirus, microtubule, nuclear pore, restriction, tegument
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/content/journals/10.1146/annurev-virology-100422-022751
2024-09-26
2024-12-11
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A Hitchhiker's Guide Through the Cell: The World According to the Capsids of Alphaherpesviruses
Annual Review of Virology 11, 215 (2024); https://doi.org/10.1146/annurev-virology-100422-022751
/content/journals/10.1146/annurev-virology-100422-022751
/content/journals/10.1146/annurev-virology-100422-022751
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