1932

Abstract

Viral envelope glycoproteins promote viral infection by mediating the fusion of the viral membrane with the host-cell membrane. Structural and biochemical studies of two viral glycoproteins, influenza hemagglutinin and HIV-1 envelope protein, have led to a common model for viral entry. The fusion mechanism involves a transient conformational species that can be targeted by therapeutic strategies. This mechanism of infectivity is likely utilized by a wide variety of enveloped viruses for which similar therapeutic interventions should be possible.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.biochem.70.1.777
2001-07-01
2024-06-18
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.biochem.70.1.777
Loading
/content/journals/10.1146/annurev.biochem.70.1.777
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error