1932

Abstract

The superfamily of intermediate filament (IF) proteins contains at least 65 distinct proteins in man, which all assemble into ∼10 nm wide filaments and are principal structural elements both in the nucleus and the cytoplasm with essential scaffolding functions in metazoan cells. At present, we have only circumstantial evidence of how the highly divergent primary sequences of IF proteins lead to the formation of seemingly similar polymers and how this correlates with their function in individual cells and tissues. Point mutations in IF proteins, particularly in lamins, have been demonstrated to lead to severe, inheritable multi-systemic diseases, thus underlining their importance at several functional levels. Recent structural work has now begun to shed some light onto the complex fine tuning of structure and function in these fibrous, coiled coil forming multidomain proteins and their contribution to cellular physiology and gene regulation.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.biochem.73.011303.073823
2004-07-01
2024-06-15
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.biochem.73.011303.073823
Loading
/content/journals/10.1146/annurev.biochem.73.011303.073823
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error