1932

Abstract

Abstract

In light of recent data showing that both helper and cytotoxic T cells can detect even a single molecule of an agonist peptide-MHC, αβ T cells are clearly a type of sensory cell, comparable to any in the nervous system. In addition, endogenous (self) peptides bound to MHCs are not just important for thymic selection, but also play an integral role in T cell activation in the response to foreign antigens. With the multitude of specificities available to most T cells, they can thus be considered as a sensory organ, trained on self-peptide-MHCs and primed to detect nonself.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.immunol.24.021605.090600
2007-04-23
2024-06-16
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.immunol.24.021605.090600
Loading
/content/journals/10.1146/annurev.immunol.24.021605.090600
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error