1932

Abstract

Traditionally, clinicians have viewed heart failure either as a problem of excessive salt and water retention caused by abnormalities of renal blood flow, or as a hemodynamic problem associated with a reduced cardiac output and excessive peripheral vasoconstriction. Recently, clinicians have begun to adopt a neurohormonal model in which heart failure progresses because of the toxic effects of endogenous biological systems that become activated in heart failure. We review the rationale for existing heart failure therapies and discuss the reasoning behind the development of some emerging therapies.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.med.53.082901.104004
2002-02-01
2024-04-21
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.med.53.082901.104004
Loading
/content/journals/10.1146/annurev.med.53.082901.104004
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error